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| 1 | The Basic Helix-Loop-Helix Transcription Factor MYC1 Is Involved in the Regulation of the Flavonoid Biosynthesis Pathway in Grapevine显示文摘以前的结果显示在葡萄藤(Vitis vinifera ) ,由 MYB 抄写因素的 flavonoid 小径基因的规定与基本 helix-loop-helix 蛋白质(bHLHs ) 取决于他们的相互作用。现在的学习描述从葡萄藤的因素说出 VvMYC1 的 bHLH 的第一功能的描述。这个抄写因素种系发生地与 Arabidopsis bHLH 蛋白质,它参予 flavonoid 生合成和表皮的房间命运的控制有关。二混血儿的试金表明了的短暂倡导者和酵母 VvMYC1 身体上与劝诱 flavonoid 小径基因的倡导者的 MYB5a, MYB5b, MYBA1/A2,和 MYBPA1 交往,这在 anthocyanin 或 proanthocyanidin (PA ) 包含了合成。另外,短暂倡导者试金表明 VvMYC1 涉及它的自己的表示的反馈规定。抄本在果浆的皮肤和种子与 anthocyanins 和舞步的合成在果浆发展相互关联期间 VvMYC1 铺平,建议 VvMYC1 涉及在这些机关的 anthocyanins 和 PA 合成的规定。同样, VvMYC1 和 VvMYBA1 的短暂表示在葡萄藤暂停房间导致 anthocyanin 合成。这些结果建议 VvMYC1 是在葡萄藤控制 anthocyanin 和 PA 生合成的 transcriptional 串联的部分。 | Imene Hichri Simon C. Heppel Jeremy Pillet Celine Leon Stefan Czemmel Serge Delrot Virginie Lauvergeat Jochen Bogs | 2010 | Molecular Plant2010，3，3： | 46 |
| 2 | Cytomegalovirus and ulcerative colitis:Place of antiviraltherapy显示文摘The link between cytomegalovirus(CMV) infection and inflammatory bowel diseases remains an important subject of debate. CMV infection is frequent in ulcerative colitis(UC) and has been shown to be potentially harmful. CMV reactivation needs to be diagnosed using methods that include in situ detection of viral markers by immunohistochemistry or by nucleic acid amplification techniques. Determination of the density of infection using quantitative tools(numbers of infected cells or copies of the genome) is particularly important. Although CMV reactivation can be considered as an innocent bystander in active flareups of refractory UC, an increasing number of studies suggest a deleterious role of CMV in this situation. The presence of colonic CMV infection is possibly linked to a decreased response to steroids and other immunosuppressive agents. Some treatments, notably steroids and cyclosporine A, have been shown to favor CMV reactivation, which seems not to be the case for therapies using anti-tumor necrosis factor drugs. According to these findings, in flare-ups of refractory UC, it is now recommended to look for the presence of CMV reactivation by using quantitative tools in colonic biopsies and to treat them with ganciclovir in cases of high viral load or severe disease. | Sylvie Pillet Bruno Pozzetto Xavier Roblin | 2016 | World Journal of Gastroenterology2016，22，6： | 19 |
| 3 | A longitudinal study of SARS-CoV-2-infected patients reveals a high correlation between neutralizing antibodies and COVID-19 severity显示文摘Understanding the immune responses elicited by SARS-CoV-2 infection is critical in terms of protection against reinfection and,thus,for public health policy and vaccine development for COVID-19.In this study,using either live SARS-CoV-2 particles or retroviruses pseudotyped with the SARS-CoV-2 S viral surface protein(Spike),we studied the neutralizing antibody(nAb)response in serum samples from a cohort of 140 SARS-CoV-2 qPCR-confirmed infections,including patients with mild symptoms and also more severe forms,including those that required intensive care.We show that nAb titers correlated strongly with disease severity and with anti-spike IgG levels.Indeed,patients from intensive care units exhibited high nAb titers;conversely,patients with milder disease symptoms had heterogeneous nAb titers,and asymptomatic or exclusive outpatient-care patients had no or low nAbs.We found that nAb activity in SARS-CoV-2-infected patients displayed a relatively rapid decline after recovery compared to individuals infected with other coronaviruses.Moreover,we found an absence of cross-neutralization between endemic coronaviruses and SARS-CoV-2,indicating that previous infection by human coronaviruses may not generate protective nAbs against SARS-CoV-2.Finally,we found that the D614G mutation in the spike protein,which has recently been identified as the current major variant in Europe,does not allow neutralization escape.Altogether,our results contribute to our understanding of the immune correlates of SARS-CoV-2-induced disease,and rapid evaluation of the role of the humoral response in the pathogenesis of SARS-CoV-2 is warranted. | Vincent Legros Solène Denolly Manon Vogrig Bertrand Boson Eglantine Siret Josselin Rigaill Sylvie Pillet Florence Grattard Sylvie Gonzalo Paul Verhoeven Omran Allatif Philippe Berthelot Carole Pélissier Guillaume Thiery Elisabeth Botelho-Nevers Guillaume Millet Jérôme Morel Stéphane Paul Thierry Walzer François-Loïc Cosset Thomas Bourlet Bruno Pozzetto | 2021 | Cellular & Molecular Immunology2021，18，2： | 3 |
| 4 | Management of cytomegalovirus infection in inflammatory bowel diseases显示文摘 | Sylvie Pillet Bruno Pozzetto Camille Jarlot Stéphane Paul Xavier Roblin | 2012 | Digestive and Liver Disease2012，，7： | 2 |
| 5 | Safety,immunogenicity,and protection provided by unadjuvanted and adjuvanted formulations of a recombinant plant-derived virus-like particle vaccine candidate for COVID-19 in nonhuman primates显示文摘Although antivirals are important tools to control severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection,effective vaccines are essential to control the current coronavirus disease 2019(COVID-19)pandemic.Plant-derived virus-like particle(VLP)vaccine candidates have previously demonstrated immunogenicity and efficacy against influenza.Here,we report the immunogenicity and protection induced in rhesus macaques by intramuscular injections of a VLP bearing a SARS-CoV-2 spike protein(CoVLP)vaccine candidate formulated with or without Adjuvant System 03(AS03)or cytidine-phospho-guanosine(CpG)1018.Although a single dose of the unadjuvanted CoVLP vaccine candidate stimulated humoral and cell-mediated immune responses,booster immunization(at 28 days after priming)and adjuvant administration significantly improved both responses,with higher immunogenicity and protection provided by the AS03-adjuvanted CoVLP.Fifteen micrograms of CoVLP adjuvanted with AS03 induced a polyfunctional interleukin-2(IL-2)-driven response and IL-4 expression in CD4 T cells.Animals were challenged by multiple routes(i.e.,intratracheal,intranasal,and ocular)with a total viral dose of 106 plaque-forming units of SARS-CoV-2.Lower viral replication in nasal swabs and bronchoalveolar lavage fluid(BALF)as well as fewer SARS-CoV-2-infected cells and immune cell infiltrates in the lungs concomitant with reduced levels of proinflammatory cytokines and chemotactic factors in the BALF were observed in animals immunized with the CoVLP adjuvanted with AS03.No clinical,pathologic,or virologic evidence of vaccineassociated enhanced disease was observed in vaccinated animals.The CoVLP adjuvanted with AS03 was therefore selected for vaccine development and clinical trials. | Stéphane Pillet Prabhu SArunachalam Guadalupe Andreani Nadia Golden Jane Fontenot Pyone Pyone Aye Katharina Röltgen Gabrielle Lehmicke Philipe Gobeil Charlotte Dubé Sonia Trépanier Nathalie Charland Marc-AndréD’Aoust Kasi Russell-Lodrigue Christopher Monjure Robert V.Blair Scott D.Boyd Rudolf P.Bohm Jay Rappaport François Villinger Nathalie Landry Bali Pulendran Brian J.Ward | 2022 | Cellular & Molecular Immunology2022，19，2： | 2 |
| 6 | A specific SPC Chart for Small-batch Control显示文摘 | Maurice Pillet | 1996 | Quality Engineering1996，8，4： | 1 |
| 7 | Broadband Vibrational Cooling of Cold Cesium Molecules: Theory and Experiments显示文摘一条宽带的使用,频率塑造了翻译联盟者寒冷铯分子上的第二激光最近表明了是也使自由的震动的度凉下来的一个很有效的方法的飞米。冷分子的一件样品,开始散布了超过几个震动的层次,因此被变成了汗衫 X 1Σ g 扎根了电子状态。我们的方法基于使所有激动的与足够宽广的一个系列的由激光光的重复的光抽占据了震动的层次,但是与一个空间轻调节的人在它的频率带宽限制了。以如此的一个方法,我们能从选择水平,分子在积累消除转变。在这篇论文,我们简短报导主要试验性的结果然后地址,以由计算机模拟的一个详细方法,观点为一“完成”分子冷却,也包括自由的旋转的度。因为抽的过程强烈取决于地面的相对形状,激动的潜力弯,通过不同激动的状态的 ro 震动的冷却理论上被比较。 | D. Sofikitis A. Fioretti S. Weber M. Viteau A. Chotia R. Horchani M. Allegrini B. Chatel D. Comparat P. Pillet | 2009 | Chinese Journal of Chemical Physics2009，22，2： | 1 |
| 8 | Surface plasmon resonance imaging (SPRi) as an alternative technique for rapid and quantitative screening of small molecules, useful in drug discovery 显示文摘 | PILLET F ROMERA C TR6VISIOL E | 2011 | Sensors and Ac- tuators B: Chemical2011，157，1： | 1 |
| 9 | A randomized controlled trial of endovascular aneurysm repair versus open surgery forabdominal aortic aneurysms in low- to moderate-risk patients显示文摘 | Becquemin JP Pillet JC Lescalie F | 2011 | J Vasc Surg2011，53，5： | 1 |
| 10 | Sex-specific effects of neonatal exposures to low levels of cadmium through maternal milk on development and immune functions of juvenile and adult rats显示文摘 | Stéphane Pillet Andrew A. Rooney Jean-Marie Bouquegneau Daniel G. Cyr Michel Fournier | 2005 | Toxicology2005，，3： | 1 |
| 11 | Masnou-Seeuws F Photoassociation in a Gas of Cold Alkali Atoms : Ⅰ-Perturbative Auantum Approach 显示文摘 | PILLET P CRUBELLIER A BLETON A | 1997 | Phys B At Mol Opt Phys1997，30，： | 1 |
| 12 | Concise review:anemia caused by viruses显示文摘 | Morinet F Leruez-Ville M Pillet S | | 0，，11： | 1 |
| 13 | Serum antimüllerian hormone levels remain stable throughout the menstrual cycle and after oral or vaginal administration of synthetic sex steroids显示文摘 | Streuli I Fraisse T Pillet C | 2008 | Fertil Steril2008，90，： | 1 |
| 14 | Efficacy of cyclosporine A in the treatment of macrophage activation syndrome in juvenile arthritis:report of five cases显示文摘 | Mouy R Stephan JL Pillet P | 1996 | J Pediatr1996，129，5： | 1 |
| 15 | Expression and regulation of metallothioneins in the rat epididymis显示文摘 | Cyr D G Dufresne J Pillet S | 2001 | Journal of Andrology2001，22，1： | 1 |
| 16 | Interleukin (lL)-2 and TL-15 have different effects on human natural killer lymphocytes 显示文摘 | Pillet AH Theze J Rose T | 2011 | Hum lmmunol2011，72，： | 1 |
| 17 | Sex-spe-cific effects of neonatal exposures to low levels of cad-mium through maternal milk on development and im-mune functions of juvenile and adult rats显示文摘 | Pillet S Rooney A A Bouquegneau J M | 2005 | Toxicol-ogy2005，209，3： | 1 |
| 18 | Serum antimullerianhormone levels remain stable throughout the menstrual cy-cle and after oral or vaginal administration of synthetic sexsteroids显示文摘 | Streuli I Fraisse T Pillet C | 2008 | Fertil Steril2008，90，2： | 1 |
| 19 | Management of cytomegalovirus infection in inflammatory bowel diseases显示文摘 | Pillet S Pozzetto B Jarlot C | 2012 | Dig Liver Dis2012，44，7： | 1 |
| 20 | Surgicatreatment of nonaneurysmal aortic arch lesions in patients withsystemic embolization显示文摘 | Goueffic Y Chaillou P Pillet JC | 2002 | J Vasc Surg2002，36，： | 1 |
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