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| 1 | Poly(ethylene glycol) conjugated nano-graphene oxide for photodynamic therapy显示文摘A novel methoxy-poly(ethylene glycol) modified nano-graphene oxide(NGO-mPEG) was designed and synthesized as a photosensitizer(PS) carrier for photodynamic therapy of cancer.NGO with a size below 200 nm was prepared using a modified Hummers' method.NGO was observed by AFM to exhibit a structure with single-layer graphene oxide sheets down to a few nanometers in height.Hydrophilic mPEG conjugation of NGO(NGO-mPEG) was found to enhance solubility in cell culture media.No apparent cytotoxicity of the NGO-mPEG was observed towards MCF-7 carcinoma cell line.Zinc phthalocyanine(ZnPc),a photosensitizer for photodynamic therapy,was loaded in the NGO-PEG through π-π stacking and hydrophobic interactions,with the drug loading efficiency up to 14 wt%.Hydrophobic ZnPc was internalized in MCF-7 cells,exhibiting a pronounced phototoxicity in the cells under Xe light irradiation.The results indicate a great potential of NGO-mPEG for photodynamic therapy of cancer. | Pilger FRANK | 2010 | Science China Chemistry2010，53，11： | 8 |
| 2 | High-contrast,fast chemical imaging by coherent Raman scattering using a self-synchronized two-colour fibre laser显示文摘Coherent Raman scattering(CRS)microscopy is widely recognized as a powerful tool for tackling biomedical problems based on its chemically specific label-free contrast,high spatial and spectral resolution,and high sensitivity.However,the clinical translation of CRS imaging technologies has long been hindered by traditional solid-state lasers with environmentally sensitive operations and large footprints.Ultrafast fibre lasers can potentially overcome these shortcomings but have not yet been fully exploited for CRS imaging,as previous implementations have suffered from high intensity noise,a narrow tuning range and low power,resulting in low image qualities and slow imaging speeds.Here,we present a novel high-power self-synchronized two-colour pulsed fibre laser that achieves excellent performance in terms of intensity stability(improved by 50 dB),timing jitter(24.3 fs),average power fluctuation(<0.5%),modulation depth(>20 dB)and pulse width variation(<1.8%)over an extended wavenumber range(2700-3550 cm^(−1)).The versatility of the laser source enables,for the first time,high-contrast,fast CRS imaging without complicated noise reduction via balanced detection schemes.These capabilities are demonstrated in this work by imaging a wide range of species such as living human cells and mouse arterial tissues and performing multimodal nonlinear imaging of mouse tail,kidney and brain tissue sections by utilizing second-harmonic generation and twophoton excited fluorescence,which provides multiple optical contrast mechanisms simultaneously and maximizes the gathered information content for biological visualization and medical diagnosis.This work also establishes a general scenario for remodelling existing lasers into synchronized two-colour lasers and thus promotes a wider popularization and application of CRS imaging technologies. | Cihang Kong Christian Pilger Henning Hachmeister Xiaoming Wei Tom H.Cheung Cora S.W.Lai Nikki P.Lee Kevin K.Tsia Kenneth K.Y.Wong Thomas Huser | 2020 | Light(Science & Applications)2020，9，1： | 5 |
| 3 | Assay for the determination of urinary 8-OHDG by highperformance liquid chromatography with electrochemical detection显示文摘 | Germadnik D Pilger A Rudiger HW | 1997 | ChromatogrB Biomed Appl1997，68，9： | 1 |
| 4 | Severe initial manifestation of psoriasis in staphylococcal infections显示文摘 | Tunus G Pilger U Aberer E | 2001 | Wien Klin Wochenschr2001，113，19： | 1 |
| 5 | Induction of DNA strand breaks by intermittent exposure to extremely-low-frequency electromagnetic fields in human diploid fibroblasts显示文摘 | Ivancsits S Diem E Pilger A | 2002 | Mutat Res2002，519，： | 1 |
| 6 | Cell type-specific genotoxic effects of intermittent extremely low-frequency electromagnetic fields显示文摘 | Ivancsits S Pilger A Diem F | 2005 | Mut Res2005，583，2： | 1 |
| 7 | Diskette drive test system using magnetic index Mark显示文摘 | ASKEW G R PILGER W | 1983 | Silvae Genetica1983，26，6： | 1 |
| 8 | Die Taxales显示文摘 | Pilger R | 1901 | Mitteilungen der Deutschen Dendrologischen Gesellschaft1901，25，： | 1 |
| 9 | Accumulation of single - strand breaks is the major cause of telomere shortening in human fibroblasts显示文摘 | Von Zglinicki T Pilger R Sitte N | 2000 | Free Radic Biol Med2000，28，1： | 1 |
| 10 | Induction of DNA strand breaks by intermittent exposure to extremelylow-frequency electromagnetic fields in human diploid firoblasts显示文摘 | Ivancsits S Diem E Pilger A | 2002 | Mutat-Res2002，519，12： | 1 |
| 11 | 8-Hydroxyo-2'-deoxyguanosine as a marker of oxidative DNA damage related to occupational and environmental exposures 显示文摘 | PILGER A RUDIGER H W | 2006 | Int Arch Occup Environ Health2006，80，1： | 1 |
| 12 | Severe initial manifestation of psoriasis in staphylococcal infections显示文摘 | Tunus G Pilger U Aberer E | 2001 | Wien Klin Wochenschr2001，113，19： | 1 |
| 13 | Enterococcus gallinarum carrying the vanA gene cluster: first report in Brazil显示文摘 | Camargo IL Barth AL Pilger K | 2004 | Braz J Med Biol Res2004，37，： | 1 |
| 14 | Das System der Gramineae显示文摘 | Pilger R | 1954 | Bot Jahrb Syst1954，，76： | 1 |
| 15 | Die Taxales显示文摘 | PILGER R | 1916 | Mitteilungen der Deutschen Dendrologischen Gesellschaft1916，25，： | 1 |
| 16 | treatment of vasospastic disease with PGE1显示文摘 | Cliffered PC Kyle V Pilger E | | 0，，： | 1 |
| 17 | The benefits of Latin hypercube sampling in sequential simulation algorithms for geostatistical applications 显示文摘 | Pilger G G Costa J F Koppe J | 2008 | Applied Earth Science2008，117，： | 1 |
| 18 | Chromosomal damage in humandiploid fibroblasts by intermittent exposure to extremely low-frequency electromagnetic fields显示文摘 | Winker R Ivancsits S Pilger A | 2005 | Mutat Res2005，585，12： | 1 |
| 19 | Rapid de- tection of Van genes in rectal swabs by real time PCR in Southern Brazil显示文摘 | Cantarelli V Cavalcante B Pilger DA | 2011 | Rev Soc Bras Med Trop2011，44，5： | 1 |
| 20 | Treatment of vasospastic disease with PGE1显示文摘 | Cliffered PC Ryle V Pilger E | 1980 | Br Med J1980，281，： | 1 |
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