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| 1 | Role of phosphoinositide 3-kinase in the pathogenesis of acute pancreatitis显示文摘A large body of experimental and clinical data supports the notion that inflammation in acute pancreatitis has a crucial role in the pathogenesis of local and systemic damage and is a major determinant of clinical severity.Thus,research has recently focused on molecules that can regulate the inflammatory processes,such as phosphoinositide 3-kinases(PI3Ks),a family of lipid and protein kinases involved in intracellular signal transduction.Studies using genetic ablation or pharmacologic inhibitors of different PI3 K isoforms,in particular the class I PI3Kδ and PI3Kγ,have contributed to a greater understanding of the roles of these kinases in the modulation of inflammatory and immune responses.Recent data suggest that PI3 Ks are also involved in the pathogenesis of acute pancreatitis.Activation of the PI3K signaling pathway,and in particular of the class IB PI3Kγ isoform,has a significant role in those events which are necessary for the initiation of acute pancreatic injury,namely calcium signaling alteration,trypsinogen activation,and nuclear factor-κB transcription.Moreover,PI3Kγ is instrumental in modulating acinar cell apoptosis,and regulating local neutrophil infiltration and systemic inflammatory responses during the course of experimental acute pancreatitis.The availability of PI3 K inhibitors selective for specific isoforms may provide new valuable therapeutic strategies to improve the clinical course of this disease.This article presents a brief summary of PI3 K structure and function,and highlights recent advances that implicate PI3 Ks in the pathogenesis of acute pancreatitis. | Enrico Lupia Luca Pigozzi Alberto Goffi Emilio Hirsch Giuseppe Montrucchio | 2014 | World Journal of Gastroenterology2014，20，41： | 15 |
| 2 | Left ventricular false tendons and electrocardiogram repolarization abnormalities in healthy young subjects显示文摘AIM To describe echocardiographically left ventricular false tendon characteristics and the correlation with ventricular repolarization abnormalities in young athletes.METHODS Three hundred and sixteen healthy young athletes from different sport disciplines were evaluated from 2009 to 2011 during routine screening for agonistic sports eligibility. All subjects, as part of standard preparticipation screening medical evaluation, underwent a basal and post step test 12-lead electrocardiogram(ECG). The athletes with abnormal T-wave flattening and/or inversion were considered for an echocardiogram evaluation and an incremental maximal exercise test on a cycle ergometer. Arterial blood pressure and heart rate, during and after exercise, were also measured.RESULTS Twenty-one of the 316 subjects(6.9%) showed false tendons in the left ventricle. The majority of false tendons(52.38%) were localized between the middle segments of the inferior septum and the lateral wall, 19.06% between the distal segments of the septum and the lateral wall, in 5 subjects between the middle segments of the anterior and inferior walls, and in one subject between the middle segments of the anterior septum and the posterior wall. ECG abnormalities, represented by alterations of ventricular repolarization, were found in 11 subjects(52.38%), 90% of these anomalies were T wave abnormalities from V1 to V3. These anomalies disappeared with an increasing heart rate following the three minute step test as well as during the execution of the maximal exercise.CONCLUSION Left ventricular false tendons are frequently localized between the middle segments of the inferior septum and the lateral wall and are statistically associated with ventricular repolarization abnormalities. | Zlatan Lazarevic Emanuela Ciminelli Federico Quaranta Fabio Sperandii Emanuele Guerra Fabio Pigozzi Paolo Borrione | 2016 | World Journal of Cardiology2016，8，10： | 4 |
| 3 | Myocarditis in athlete and myocardial bridge:An innocent bystander?显示文摘Myocarditis is a bacterial or viral inflammatory disease,often unnoticed or misdiagnosed.Athletes with myocarditis must stop practicing their activity since International medical Literature described some cases of sudden death.In the present report,we describe a case of an asymptomatic,apparently healthy,competitive athletes,who was diagnosed a myocarditis and as incidental finding a myocardial bridging.We focused the attention on the importance of anamnesis,electrocardiogram and athletes' entourage for the diagnosis of such insidious pathologies and we evaluated the follow up,focusing the attention on electrocardiogram changes as well as on restitution ad integrum and prognosis,especially for the athletes. | Federico Quaranta Emanuele Guerra Fabio Sperandii Francesco De Santis Fabio Pigozzi Leonardo Calò Paolo Borrione | 2015 | World Journal of Cardiology2015，7，5： | 3 |
| 4 | Preparticipation screening for the detection of cardiovascular abnormalities that may cause sudden death in competitive athletes 显示文摘 | Pigozzi F Spataro A Fagnani F | 2003 | Br J Sports Med2003，37，1： | 1 |
| 5 | The application of shock-waves therapy in the treatment of resistant chronic painful shoulder显示文摘 | Pigozzi E Giombini A Parisi A | 2000 | J Sports Med Phys Fitness2000，40，： | 1 |
| 6 | Molecular cloning and characterization of the germline-restricted chromosome sequence in the zebra finch显示文摘 | Itoh Y Kampf K Pigozzi MI Arnold AP | | 0，，04： | 1 |
| 7 | Effects of Size Reduction on the Structure and Magnetic Properties of Core-shell Ni3Si/silica Nanoparticles Prepared by Electrochemical Synthesis 显示文摘 | Pigozzi G Mukherji D Elerman Y | 2014 | Journal of Alloys and Compounds2014，584，： | 1 |
| 8 | Understanding platelet dysfunction in sepsis 显示文摘 | Pigozzi L Aron JP Ball J | 2016 | Intensive Care Med2016，42，4： | 1 |
| 9 | Conversion from vagal to sympathetic predominance with strenuous training in high-performance world class athletes显示文摘 | Iellamo F Legramante J M Pigozzi F | 2002 | Circulation2002，105，23： | 1 |
| 10 | Validation of a novel method for measuring Intra-abdnnfinal pressure and gastric residual volume in critically ill patients 显示文摘 | Van Stappen J Pigozzi C Tepaske R | 2014 | Anaesthesiol Intensive T- her2014，46，4： | 1 |
| 11 | Bone mineral density and sport : effect of physical activity显示文摘 | Pigozzi F Rizzo M Giombini A | 2009 | J Sports Med Phys Fitness2009，49，2： | 1 |
| 12 | Conversion from vagal to sympathetic predominance with strenuous training in high-performance world class athletes显示文摘 | Iellamo F Legramante JM Pigozzi F | 2002 | Circulation2002，105，23： | 1 |
| 13 | T-wave and heart rate variability changes to assess training in world-class athletes显示文摘 | Iellamo F Pigozzi F Spataro A | 2004 | Med Sci Sports Exerc2004，36，8： | 1 |
| 14 | Preparticipation screening for the detection of cardiovascular abnormalities that may cause sudden death in competitive athletes显示文摘 | Pigozzi F Spataro A Fagnani F | 2003 | Br J Sports Med2003，37，1： | 1 |
| 15 | A hierarchy of spatial marginality through spatial filtering 显示文摘 | Pigozzi B Wm | 2004 | The Professional Geogapher2004，56，4： | 1 |
| 16 | Bone mineral density and sport:effect of physical activity显示文摘 | Pigozzi F Rizzo M Giombini A | 2009 | Sports Med Phys Fitness2009，49，2： | 1 |
| 17 | Occupational and industrial diversification in the United States:Implications of the new spatial division of labor 显示文摘 | BAGCHI-SEN S PIGOZZI B W | 1993 | Professional Geographer1993，45，： | 1 |
| 18 | Conversion from vagal to sympathetic predominance with strenuous training in high-performance world class athletes显示文摘 | IELLAMO F LEGRAMANTE J M PIGOZZI F et a l | 2002 | Circula tion2002，105，23： | 1 |
| 19 | T-wave and Heart Rate Variability Changes to Assess Training in World-class Athletes显示文摘 | FERDIMANDO LELLAMO FABIO PIGOZZI ANTONIO SPATARO | 2004 | Med Sci Sports Exe2004，36，8： | 1 |
| 20 | Conversion from vagal to sympathetic predominance with strenuous training in high-performance world class athletes 显示文摘 | Iellamo F Legramante J M Pigozzi F | 2002 | Cir- culation2002，105，23： | 1 |
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