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| 1 | Regulation of Torpor in the Gray Mouse Lemur:Transcriptional and Translational Controls and Role of AMPK Signaling显示文摘The gray mouse lemur(Microcebus murinus) is one of few primate species that is able to enter daily torpor or prolonged hibernation in response to environmental stresses. With an emerging significance to human health research, lemurs present an optimal model for exploring molecular adaptations that regulate primate hypometabolism. A fundamental challenge is how to effectively regulate energy expensive cellular processes(e.g., transcription and translation) during transitionsto/from torpor without disrupting cellular homeostasis. One such regulatory mechanism is reversible posttranslational modification of selected protein targets that offers fine cellular control without the energetic burden. This study investigates the role of phosphorylation and/or acetylation in regulating key factors involved in energy homeostasis(AMP-activated protein kinase, or AMPK, signaling pathway), m RNA translation(eukaryotic initiation factor 2a or e IF2 a, eukaryotic initiation factor 4E or e IF4 E, and initiation factor 4E binding protein or 4EBP), and gene transcription(histone H3) in six tissues of torpid and aroused gray mouse lemurs. Our results indicated selective tissue-specific changes of these regulatory proteins. The relative level of Thr172-phosphorylated AMPKa was significantly elevated in the heart but reduced in brown adipose tissue during daily torpor, as compared to the aroused lemurs, implicating the regulation of AMPK activity during daily torpor in these tissues. Interestingly, the levels of the phosphorylated e IFs were largely unaltered between aroused and torpid animals. Phosphorylation and acetylation of histone H3 were examined as a marker for transcriptional regulation. Compared to the aroused lemurs, level of Ser10-phosphorylated histone H3 decreased significantly in white adipose tissue during torpor, suggesting global suppression of gene transcription. However, a significant increase in acetyl-histone H3 in the heart of torpid lemurs indicated a possible stimulation of transcriptional activity of this tissue. Overall, our study demonstrates that AMPK signaling and posttranslational regulation of selected proteins may play crucial roles in the control of transcription/translation during daily torpor in mouse lemurs. | Jing Zhang Shannon N.Tessier Kyle K.Biggar Cheng-Wei Wu Fabien Pifferi Martine Perret Kenneth B.Storey | 2015 | Genomics, Proteomics & Bioinformatics2015，13，2： | 2 |
| 2 | Pediatric bronchiectasis : Correlation of HRCT,ventilation and perfusion scintigraphy,and pulmonary function testing显示文摘 | Pifferi M Caramella D Bulleri A | 2004 | Pediatr Pulmonol2004，38，4： | 1 |
| 3 | Endoplasmic reticulum stress and alteration in calcium homeostasis are involved in cadrnium-induced apoptosis显示文摘 | BIAGIOLI M PIFFERI S RAGGHIANTI M | 2008 | Cell Calcium2008，43，2： | 1 |
| 4 | An improved synthesis of γ-, δ-, and ε-lactams 显示文摘 | Pellegata R Pinza M Pifferi G | 1978 | Synth Commun1978，，： | 1 |
| 5 | Nasal nitric oxide and nitric oxide synthase expression in primary ciliary dyskinesia 显示文摘 | Pifferi M Bush A Maggi F | 2011 | Eur Respir J2011，37，3： | 1 |
| 6 | Fish,docosahexaenoic acid and Alzbeimer' s disease显示文摘 | Cunnane S C Plourde M Pifferi F | 2009 | Prog Lipid Res2009，48，5： | 1 |
| 7 | Montelukast and airway remodeling in children with chronic persistent asthma: an open study 显示文摘 | Pifferi M Caramella D Ragazzo V De Marco E Pietrobelli A Boner AL | 2004 | Pediatr Allergy Immunol2004，15，5： | 1 |
| 8 | Whole cell biocatalysis for an desulfurization process显示文摘 | Setti L Lanzarini G Pifferi P G | 1997 | Fuel Processing Technology1997，52，： | 1 |
| 9 | Eosinophile cationic protein in infants with respiratory syncytial virus bronchiolitis:predictive value for subsequent development of persistent wheezing显示文摘 | Pifferi M Ragazzo V Garamella D | 2001 | Pedistr Pulmonl2001，31，5： | 1 |
| 10 | Uncommon pulmonary presentation of IgG4-related disease in a 15-year-old boy显示文摘 | Pifferi M Di Cicco M Bush A | 2013 | Chest2013，144，： | 1 |
| 11 | Synthesis and anti-ulcer activity of new derivatives of glycyrrhetic显示文摘 | C Farina M Pinza G Pifferi | | 0，，01： | 1 |
| 12 | Human bocavirus in Italian patients with respiratory diseases 显示文摘 | Maggi F Andreali E Pifferi M | 2007 | J Clin Virol2007，38，： | 1 |
| 13 | Human cord bloodCD133 + stem cells transplanted to nod-scid mice provideconditions for regeneration of olfactory neuroepithelium afterpermanent damage induced by dichlobenil显示文摘 | Franceschini V Bettini S Pifferi S | 2009 | Stem Cells2009，27，4： | 1 |
| 14 | Purification and separation of oenocyanin anthocyanins on sulphoxyethylcolluluse显示文摘 | Spagna G Pifferi P G | 1992 | Food Chemistry1992，44，： | 1 |
| 15 | Transplanted humanadipose tissue-derived stem cells engraft and induce regeneration inmice olfactory neuroepithelium in response to dichlobenilsubministration 显示文摘 | Franceschini V Bettini S Pifferi S | 2014 | Chem Senses2014，39，7： | 1 |
| 16 | Immobilized β-glucoaidase for the winemaking industry:study of biocatalystoperational stability in laboratory-scale continuous reactors 显示文摘 | CANTARELLA M SPAGNA G PIFFERI P G | 1999 | Process Bioehem1999，35，12： | 1 |
| 17 | Eosinophil cationic protein in infants with respiratory syncytial virus bronchiolitis: predictive value for subsequent development of persistent wheezing 显示文摘 | Pifferi M Ragazzo V Caramella D | 2001 | Pediatric Pulmonol2001，31，6： | 1 |
| 18 | Associations between nasal torquetenovirus load and spirometric indices in children with asthma显示文摘 | Pifferi M Maggi F Andreoli E | 2005 | J Infect Dis2005，192，7： | 1 |
| 19 | Human bocavirus in Italian patients with respiratory diseases 显示文摘 | Maggi F Atodreoli E Pifferi M | 2007 | J Clin Virol2007，38，4： | 1 |
| 20 | Montelukast and airway remodeling in children with chronic persistent asthma: an open study 显示文摘 | PIFFERI M CARAMELLA D RAGAZZO V | 2004 | Pediatr Allergy Immunol2004，15，5： | 1 |
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