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| 1 | Adjuvant chemotherapy for gastric cancer:Current evidence and future challenges显示文摘Gastric cancer still represents one of the major causes of cancer mortality worldwide.Patients survival is mainly related to stage,with a high proportion of patients with metastatic disease at presentation.Thus,the cure rate largely depend upon surgical resection.Despite the additional,albeit small,benefit of adjuvant chemotherapy has been clearly demonstrated,no general consensus has been reached on the best treatment option.Moreover,the narrow therapeutic index of adjuvant chemotherapy(i.e.,limited survival benefit with considerable toxicity)requires a careful assessment of expected risks and benefits for individual patients.Treatment choices vary widely based on the different geographic areas,with chemotherapy alone more often preferred in Europe or Asia and chemoradiotherapy in the United States.In the present review we discuss the current evidence and future challenges regarding adjuvant chemotherapy in curatively resected gastric cancer with particular emphasis on the recently completed landmark studies and meta-analyses.The most recent patient-level meta-analysis demonstrated the benefit of adjuvant chemotherapy over curative surgery;the same Authors also showed that disease free survival may be used as a surrogate end-point for overall survival.We finally discuss future research issues such as the need of economic evaluations,development of prognostic or predictive biomarkers,and the unmet clinical need of trials comparing perioperative chemotherapy with adjuvant treatment. | Rosalba Miceli Gianluca Tomasello Giacomo Bregni Maria Di Bartolomeo Filippo Pietrantonio | 2014 | World Journal of Gastroenterology2014，20，16： | 12 |
| 2 | Role of MGMT as biomarker in colorectal cancer显示文摘O6-methylguanine DNA methyltransferase(MGMT) gene promoter methylation plays an important role in colorectal carcinogenesis, occurring in about 30%-40% of metastatic colorectal cancer. Its prognostic role has not been defined yet, but loss of expression of MGMT, which is secondary to gene promoter methylation, results in an interesting high response to alkylating agents such as dacarbazine and temozolomide. In a phase 2 study on heavily pre-treated patients with MGMT methylated metastatic colorectal cancer, temozolomide achieved about 30% of disease control rate. Activating mutations of RAS or BRAF genes as well as mismatch repair deficiency may represent mechanisms of resistance to alkylating agents, but a dose-dense schedule of temozolomide may potentially restore sensitivity in RAS-mutant patients. Further development of temozolomide in MGMT methylated colorectal cancer includes investigation of synergic combinations with other agents such as fluoropyrimidines and research for additional biomarkers, in order to better define the role of temozolomide in the treatment of individual patients. | Alessandro Inno Giuseppe Fanetti Maria Di Bartolomeo Stefania Gori Claudia Maggi Massimo Cirillo Roberto Iacovelli Federico Nichetti Antonia Martinetti Filippo de Braud Ilaria Bossi Filippo Pietrantonio | 2014 | World Journal of Clinical Cases2014，2，12： | 10 |
| 3 | Comparison of Two Kinds of Intraperitoneal Chemotherapy Following Complete Cytoreductive Surgery of Colorectal Peritoneal Carcinomatosis显示文摘 | Dominique Elias MD PhD Emmanuel Benizri MD Daniela Pietrantonio MD Paola Menegon MD David Malka MD PhD Bruno Raynard MD | 2007 | Annals of Surgical Oncology2007，，2： | 2 |
| 4 | Structural Neuroimaging of ConcomitantDepressive Symptoms in Amnestic Mild Cognitive Impairment: A Pilot Study显示文摘 | Morin J F Mouiha A Pietrantonio S | 2012 | Dement Geriatr Cogn Dis Extra2012，2，30： | 1 |
| 5 | The mode of Actions of Bacillus Thuringiensis Endotoxins显示文摘 | GILL S S COWLES E A Pietrantonio P V | 1992 | Ann Rev Entomol1992，，37： | 1 |
| 6 | Comparison of Two Kinds of Intraperitoneal Chemotherapy Following Complete Cytoreductive Surgery of Colorectal Peritoneal Carcinomatosis显示文摘 | Dominique Elias Emmanuel Benizri Daniela Pietrantonio Paola Menegon David Malka Bruno Raynard | 2007 | Annals of Surgical Oncology2007，，： | 1 |
| 7 | Cloning and expression analysis of a 5hT7-like serotonin receptor cDNA from mosquito Aedes aegypti female excretory and respiratory systems显示文摘 | PIETRANTONIO P JAGGE C MCDOWELL C | 2001 | Insect Molecular Biology2001，10，4： | 1 |
| 8 | Continuous renal replacement therapy and charcoal plasmaperfusion in treatment of Amanita mushroom poisoning显示文摘 | Splendiani G Zazzaro D Di Pietrantonio P | 2000 | Artificial Organs2000，24，4： | 1 |
| 9 | Comparison of two kinds of intraperitoneal chemotherapy following complete cytoreduetive surgery of coloreetal peritoneal carcinomatosis 显示文摘 | Elias D Benizri E Di Pietrantonio D | 2007 | Ann Surg Oncol2007，14，2： | 1 |
| 10 | Early tumour shrinkage as a prognostic factor and surrogate end - point in colorectal cancer: A systematic review and pooled - analysis显示文摘 | Petrelli F Pietrantonio F Cremolini C | 2015 | Eur J Cancer2015，51，7： | 1 |
| 11 | A review onbiomarkers for prediction of treatment outcome in gastric cancer显示文摘 | Pietrantonio F DE Braud F DA Prat V | 2013 | Anticancer Res2013，33，4： | 1 |
| 12 | Tidal and Polar Modeling Effects in regional GPS Networks显示文摘 | L Biagi G Pietrantonio F Roguzzi | 2005 | Geophysics Research Abstracts2005，7，04： | 1 |
| 13 | The mode of Bacillus thuringiensis endotoxins显示文摘 | Gillss S S Cowles E A Pietrantonio P V | 1992 | Annu Rev Entomol1992，6，11： | 1 |
| 14 | Atlantoaxial rotatory dislocation (AARD) in pediatric age: MRI study on conservative treatment with Philadelphia collar-experience of nine consecutive cases 显示文摘 | Landi A Pietrantonio A Marotta N | 2012 | Eur Spine J2012，21，1： | 1 |
| 15 | The mode of action of Bacillus thuringiensis endotoxins 显示文摘 | Gill S S Cowles E A Pietrantonio P V | 1992 | Annual Review Entomology1992，37，： | 1 |
| 16 | Comparison of soxlet, shaking, and microwave assisted extraction techniques for determination of PCB congeners in a marine sediment显示文摘 | Cicero A M Pietrantonio E Romanelli G | 2000 | Bull Environ Contain Toxicol2000，65，： | 1 |
| 17 | Circulating tumor cells as a longitudinal biomarker in patients with advanced chemorefractory,RAS-BRAF wild-type colorectal cancer receiving cetuximab or panitumumab显示文摘 | MUSELLA V PIETRANTONIO F DI BUDUO E | 2015 | Int J Cancer2015，137，6： | 1 |
| 18 | The Mode of Action of Bacillus Thuringiensis Endotoxins显示文摘 | S S Gill E A Cowles P V Pietrantonio | 1992 | Annual Review of Entomology1992，，： | 1 |
| 19 | MicroR- NAs in non-small cell lung cancer: current status and future therapeutic promises 显示文摘 | Cortinovis D Monica V Pietrantonio F | 2013 | Curr Pharm Des2013，19，35： | 1 |
| 20 | continuous re-nal replacement therapy and charcoal plasma perfusion in treatmentof Amanita mushroom poisoning显示文摘 | Splendiani G Zazzaro D Pietrantonio P D | 2000 | Artificial Organs2000，24，4： | 1 |
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