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| 1 | Probiotics in the Management of Inflammatory Bowel Disease显示文摘 | Daisy Jonkers John Penders Ad Masclee Marieke Pierik | 2012 | Drugs2012，，6： | 5 |
| 2 | Pharmacogenetics in inflammatory bowel disease显示文摘遗传药理学是在在药反应的可变性之间的协会的学习并且(或) 在基因的药毒性和多型性。科学的这个领域的目标是使药适应一个病人的特定的基因背景因此使他们更有效、安全。在这篇文章,我们在影响的基因描述变体在煽动性的肠疾病( IBD )的治疗使用的普通的药的功效或毒性, ulcerative ( UC ),和 Crohn 包括 sulfasalazine 和 mesalazine 是疾病( CD ), azathioprine ( AZA )和 6-mercaptopurine ( 6-MP ), methotrexate ( MTX ), glucocorticosteroids ( CS )和 infliximab 。而且, pharmacogenetic 研究的困难一般来说并且更明确地在 IBD 被描述。尽管遗传药理学是已经贡献了一些药的行动的内在的机制的更好的理解的一个有希望的领域,在 IBD 使用,翻译直到现在成每日的实践的唯一的发现是在 thiopurine S-methyltransferase (TPMT ) 基因多型性和 thiopurine 治疗的 hematological 毒性之间的关系。在未来,在很好描绘的耐心的队组织研究是必要的谁一致地被对待并且系统地评估了以便测定药反应更客观地。一个努力应该被作从为 pharmacogenetic 研究在适当知情同意以后在临床的药试用注册的所有病人收集 genomic DNA。 | Marie Pierik Paul Rutgeerts Robert Vlietinck Severine Vermeire | 2006 | World Journal of Gastroenterology2006，12，23： | 3 |
| 3 | Illumina Sequencing Technology as a Method of Identifying T-DNA Insertion Loci in Activation- Tagged Arabidopsis thaliana Plants显示文摘 | Joanna K. Polko Mohamed-Ramzi Temanni Martijn van Zanten Wilbert van Workum Sven Iburg Ronald Pierik Laurentius A.C.J. Voesenek Anton J.M. Peeters | 2012 | Molecular Plant2012，5，4： | 3 |
| 4 | Control of Plant Growth and Defense by Photoreceptors:From Mechanisms to Opportunities in Agriculture显示文摘Plants detect and respond to the proximity of competitors using light signals perceived by photoreceptor proteins.A low ratio of red to far-red radiation(R:FR ratio)is a key signal of competition that is sensed by the photoreceptor phytochrome B(phyB).Low R:FR ratios increase the synthesis of growth-related hormones,including auxin and gibberellins,promoting stem elongation and other shade-avoidance responses.Other photoreceptors that help plants to optimize their developmental configuration and resource allocation patterns in the canopy include blue light photoreceptors,such as cryptochromes and phototropins,and UV receptors,such as UVR8.All photoreceptors act by directly or indirectly controlling the activity of two major regulatory nodes for growth and development:the COP1/SPA ubiquitin E3 ligase complex and the PIF transcription factors.phyB is also an important modulator of hormonal pathways that regulate plant defense against herbivores and pathogens,including the jasmonic acid signaling pathway,In this Perspective,we discuss recent advances on the studies of the mechanisms that link photoreceptors with growth and defense.Understanding these mechanisms is important to provide a functional platform for breeding programs aimed at improving plant productivity,stress tolerance,and crop health in species of agronomic interest,and to manipulate the light environments in protected agriculture. | Ronald Pierik Carlos L.Ballare | 2021 | Molecular Plant2021，14，1： | 2 |
| 5 | Ethylene is required in tobacco to successfully compete with proximate neighbours 显示文摘 | Pierik R Visser E J W Kroon H D | 2003 | Plant Cell and Environment2003，26，8： | 1 |
| 6 | Interactions between ethylene and gibberellins in phytochrome -mediated shade avoidance responses in tobacco 显示文摘 | Pierik R Cuppens M L Voesenek L A | 2004 | Plant Physiology2004，136，10： | 1 |
| 7 | Inertial response of variable speed wind turbines显示文摘 | Morren J Pierik J Haan S W | 2006 | Electric Power Systems Research2006，76，2： | 1 |
| 8 | New glycyl radical enzymes catalysing key metabolic steps in anaerobic bacteria显示文摘 | Selmer T Pierik A J Heider J | 2005 | Biological Chemistry2005，386，10： | 1 |
| 9 | Real time quantitative amplification detection on a microarray:towards high multiplex quantitative PCR显示文摘 | PIERIK A BOAMFA M ZELST M V | 2012 | Lab Chip2012，12，10： | 1 |
| 10 | Serum inhibin B as a markerof spermatogenesis显示文摘 | Pierik FH Vreeburg JT Stijnen T | 1998 | J Clin Endocrinol Metab1998，83，9： | 1 |
| 11 | Endoscopic versus open subfascial division of incompetent perforating veins in the treatment of venous leg ulceration;long-term follow-up显示文摘 | van Gent W B Pierik E G | 2001 | J Vasc Surg2001，33，5： | 1 |
| 12 | Does folio acid and zinc sulphate intervention affect endocrine parameters and sperm characteristics in men显示文摘 | Ebisch IM Pierik FH De Jong | 2009 | Int J Androl2009，29，2： | 1 |
| 13 | Subunit composition of the glycyl radxcal enzyme p-nyctroxypnenyiacetate decarboxylas A small subunit, HpdC, is essential for catalytic activity显示文摘 | Andrei P I Pierik A J Zauner S | 2004 | European Journal of Biochemistry2004，271，11： | 1 |
| 14 | Seed germination and further development of plantlets of Paphiopedilum ciliolare Pfitz in vitro 显示文摘 | Pierik R L M Sprenkels P A Vanderharst B | 1988 | Sci Horti1988，34，： | 1 |
| 15 | Exergetic evaluation of biomass gasification显示文摘 | Ptasinski K J Prins M J Pierik A | 2007 | Energy2007，32，4： | 1 |
| 16 | Endoscopic versus open subfascial division of incompetent perforating veins in the treatment of venous leg ulceration: A randamized trial显示文摘 | Vrk H v Hop W C T | 1997 | J Vasc Surg1997，26，6： | 1 |
| 17 | Maternal and paternal risk factors for cryptorchidism and hypospadias:a case-control study in newborn boys显示文摘 | Pierik FH Burdorf A Deddens JA | 2004 | Environ Health Perspect2004，112，15： | 1 |
| 18 | The effect of cryptorchidism on inhibin B in a subfertile population显示文摘 | de Gouveia Brazao CA Pierik FH Erenpreiss Y | 2003 | Clin Endocrinol (Oxf)2003，59，1： | 1 |
| 19 | Review article: the association of diet with onset and relapse in patients with inflammatory bowel disease显示文摘 | C. E. G. M. Spooren M. J. Pierik M. P. Zeegers E. J. M. Feskens A. A. M. Masclee D. M. A. E. Jonkers | 2013 | Aliment Pharmacol Ther2013，，10： | 1 |
| 20 | Multicenter study of strains of respiratory syncytial virus 显示文摘 | Anderson L J Hendry R M Pierik L T | 1991 | J Infect Dis1991，163，： | 1 |
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