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| 1 | Microwave ablation of hepatocellular carcinoma显示文摘Although surgical resection is still the optimal treatment option for early-stage hepatocellular carcinoma(HCC) in patients with well compensated cirrhosis,thermal ablation techniques provide a valid nonsurgical treatment alternative,thanks to their minimal invasiveness,excellent tolerability and safety profile,proven efficacy in local disease control,virtually unlimited repeatability and cost-effectiveness.Different energy sources are currently employed in clinics as physical agents for percutaneous or intra-surgical thermal ablation of HCC nodules.Among them,radiofrequency(RF) currents are the most used,while microwave ablations(MWA) are becoming increasingly popular.Starting from the 90s',RF ablation(RFA) rapidly became the standard of care in ablation,especially in the treatment of small HCC nodules;however,RFA exhibits substantial performance limitations in the treatment of large lesions and/or tumors located near major heat sinks.MWA,first introduced in the Far Eastern clinical practice in the 80s',showing promising results but also severe limitations in the controllability of the emitted field and in the high amount of power employed for the ablation of large tumors,resulting in a poor coagulative performance and a relatively high complication rate,nowadays shows better results both in terms of treatment controllability and of overall coagulative performance,thanks to the improvement of technology.In this review we provide an extensive and detailed overview of the key physical and technical aspects of MWA and of the currently available systems,and we want to discuss the most relevant published data on MWA treatments of HCC nodules in regard to clinical results and to the type and rate of complications,both in absolute terms and in comparison with RFA. | Guido Poggi Nevio Tosoratti Benedetta Montagna Chiara Picchi | 2015 | World Journal of Hepatology2015，7，25： | 28 |
| 2 | Coronary microvascular dysfunction in diabetes mellitus:A review显示文摘The exploration of coronary microcirculatory dysfunction in diabetes has accelerated in recent years.Cardiac function is compromised in diabetes.Diabetic patients manifest accelerated atherosclerosis in coronary arteries.These data are confirmed in diabetic animal mod-els,where lesions of small coronary arteries have been described.These concepts are epitomized in the classic microvascular complications of diabetes,i.e.blindness,kidney failure and distal dry gangrene.Most importantly,accumulating data indicate that insights gained from the link between inflammation and diabetes can yield predictive and prognostic information of considerable clinical utility.This review summarizes the evidence for the predisposing factors and the mechanisms involved in diabetes,and assesses the current state of knowledge regarding the triggers for inflammation in this disease.We evaluate the roles of hyperglycemia,oxidative stress,polyol pathway,protein kinase C,advanced glycation end products,insulin resistance,peroxisome proliferator-activated receptor-γ,inflammation,and diabetic cardiomyopathy as a 'stem cell disease'.Furthermore,we discuss the mechanisms responsible for impaired coronary arteriole function.Finally,we consider how new insights in diabetes may provide innovative therapeutic strategies. | Andrea Picchi Stefano Capobianco Marta Focardi | 2010 | World Journal of Cardiology2010，2，11： | 24 |
| 3 | 欧洲和中国的心脏与肾脏远程缺血预适应研究:一项随机对照试验显示文摘远程缺血预适应(remote ischemic preconditioning,RIPC)对经皮冠状动脉介入治疗(percutaneous coronary intervention,PCI)术后造影剂肾病(contrast-induced nephropathy,CIN)的潜在保护作用尚待确定。该研究为双盲、随机、安慰剂对照的多中心研究,纳入年龄〈85岁,肾清除率为30~60mL/(min·1.73m^2)的有临床适应证的患者,除了直接PCI外均按1∶1给予RIPC或标准治疗。主要终点是CIN的发生率。次要终点是围手术期心肌梗死(peri-procedural myocardial infarction,PMI)的发生率。 | 刘青 叶鹏 Moretti C Cerrato E Cavallero E Lin S Rossi ML Picchi A Sanguineti F Ugo F Palazzuoli A Bertaina M Presbitero P Shao-Liang C Pozzi R Giammaria M Limbruno U Lefèvre T Gasparetto V Garbo R OmedèP Sheiban I Escaned J Biondi-Zoccai G Gaita F Perl L D'Ascenzo F | 2018 | 中华高血压杂志2018，26，4： | 3 |
| 4 | CLIMATE CHANGE AND THE PROTECTION OF HUMAN RIGHTS: THE ISSUE OF "CLIMATE REFUGEES"显示文摘 | Marta Picchi | 2016 | US-China Law Review2016，13，7： | 2 |
| 5 | Chitosan antitranspirant activity is due to abscisic acid-dependent stomatal closure 显示文摘 | Iriti M Picchi V Rossoni M | 2009 | Environmental and Experimental Botany2009，66，3： | 1 |
| 6 | Intracoronary bivalirudin for no reflow reversal: a second chance to treat this disorder? 显示文摘 | CORTESE B PICCHI A MICHELI A | 2009 | J Thromb Thrombolysis2009，28，1： | 1 |
| 7 | Maturation-induces endothelial dysfunction via vascular inflammation in diabetic mice显示文摘 | Cuihua Zhang MD PhD Yoonjung Park Andrea Picchi Barry J. Potter | 2008 | Basic Research in Cardiology2008，，5： | 1 |
| 8 | Blind equalization and carrier recovery using a ‘stop-and-go' decision-directed algorithm显示文摘 | PRATI G | 1987 | IEEE Transactions on Commun1987，35，9： | 1 |
| 9 | Genotypes in matrix metalloproteinase 9 are a risk factor for COPD显示文摘 | Tesfaigzi Y Myers O B Stidley C A Schwalm K Picchi M Crowell R E Gilliland F D Belinsky S A | 2006 | Int J Chron Obstruct Pulmon Dis2006，1，3： | 1 |
| 10 | The Levels of Bilingualism Hypothesis:Cognitive and Linguistic Developmental Aspects显示文摘 | Picchi S I | | 0，，： | 1 |
| 11 | Chitosan antitranspirant activity is due to abscisic acid-dependent stomatal closure显示文摘 | Iriti M Picchi V Rossoni M | 2009 | Environmental and Experimental Botany2009，66，3： | 1 |
| 12 | Blind equalization and carrier recovery using a 'stop-and-go' decision-directed algorithm 显示文摘 | PICCHI G PRATI G | 1987 | IEEE Transactions on Communications1987，35，9： | 1 |
| 13 | Blind equalization and carrier recovery using a' stop-and-go' decision-directed algorithm显示文摘 | Picchi G Prati G | 1987 | IEEE Trans on Communications1987，35，9： | 1 |
| 14 | Epigenetic repression of CCDC37 and MAP1B links chronic obstructive pulmonary disease to lung cancer显示文摘 | Tessema M Yingling CM Picchi MA | 2015 | J Thorac Onco2015，10，8： | 1 |
| 15 | Impact of Iso-Osmolar Versus Low-Osmolar Contrast Agents on Contrast-Induced Nephropathy and Tissue Reperfusion in Unselected Patients With ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention (From the Contrast显示文摘 | Leonardo Bolognese Giovanni Falsini Carsten Schwenke Simone Grotti Ugo Limbruno Francesco Liistro Arcangelo Carrera Paolo Angioli Andrea Picchi Kenneth Ducci Carlo Pierli | 2012 | The American Journal of Cardiology2012，，1： | 1 |
| 16 | Blind equalization and carrier recover recovering using a “stop-and-Go” Decision-Directed algorithm 显示文摘 | Picchi G Prati G | 1987 | IEEE Trans on commmunication1987，，35： | 1 |
| 17 | Epigenetic Repression of CCDC37 and MAPIB Links Chronic Obstructive Pulmonary Disease to LungCancer 显示文摘 | TESSEMA M YINGLING CM PICCHI MA | 2015 | J Thorac Oncol2015，10，8： | 1 |
| 18 | Tumor necrosis factor-alpha induces endothelial dysfunction in the prediabetic metabolic syndrome显示文摘 | Picchi A Gao X Belmadani S | 2006 | Circ Res2006，99，： | 1 |
| 19 | Perceived benefits of littoral wetlands in Uganda:A focus on the Nabugabo wetlands显示文摘 | Bikangaga S Picchi M P | | 0，，： | 1 |
| 20 | Necrosis factor alpha induces endothelial dysfunction in the prediabetie metabolic syndrome显示文摘 | Picchi A Gao X Belmadani S | 2006 | Circ Res2006，99，1： | 1 |
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