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10篇 您的检索式：作者名="Philips HS"

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		题名	作者	年代	出处	被引量
	1	Correlation and prognostic significance of beta-galactoside alpha-2,6-sialyltransferase and serum monosialylated alpha-fetoprotein in hepatocellular carcinoma显示文摘AIM: To investigate the correlation between tissue ST6Gal I and serum msAFP in HCC patients, and to investigate their prognostic significance.METHODS: Preoperative sera,paired tumorous and non-tumorous tissues were collected from 19 consecutive patients who had undergone surgical resection of HCC.ST6Gal T activities in the tissues were measured by an in vitro microsomal enzyme activity assay. The percentages of tumor-specific msAFP in the sera were also estimated by an isoelectric focusing-immunoblotting assay.RESULTS: The tumor ST6Gal I activity was negatively correlated with serum msAFP percentage (r = -0.53,P = 0.019). Both decreased tumor ST6Gal I activity andincreased serum msAFP percentage were associatedwith poor tumor cell differentiation. Univariate analyses showed that both decreased tumor ST6Gal T activity (P = 0.028), increased serum msAFP percentage (P = 0.034) and poor tumor cell differentiation (P = 0.031)were associated with shorter overall survival. Multivariate analysis using the Cox regression model showed that the preoperative serum msAFP percentage (P = 0.022)and tumor cell differentiation status (P = 0.048) were independent prognostic indicators for patient overall survival.CONCLUSION: Our results indicate that the presence of msAFP in blood circulation is associated with a decreased activity of ST6Gal I activity in HCC. Both tissue ST6Gal I and serum msAFP are potential prognostic markers for patients with operable HCC.	Terence CW Poon Clarissa HS Chiu Paul BS Lai Tony SK Mok Benny Zee Anthony TC Chan Joseph JY Sung Philip J Johnson	2005	World Journal of Gastroenterology2005，11，42：	4
	2	GDNF:a potent survival factor for motoneurons present in peripheral nerve and muscle显示文摘	Henderson CE Philips HS Pollock RA	1994	Science1994，266，5185：	1
	3	Production of IL -5 by human NK cells and regulation of IL - 5 secretion by IL-4, IL-10, and IL-12显示文摘	Warren HS Kinnear BF Philips JH	1995	J Immunol1995，154，10：	1
	4	GDNF:A potent survival factor for motoneurons present in peripheral nerve and muscle显示文摘	Henderson CE Philips HS Pollock RA	1994	Scince1994，266，：	1
	5	GDNF:A potent survival factor for motoneurons present in peripheral nerve and muscle显示文摘	Philips HS Pollock RA	1994	Science1994，266，：	1
	6	Jen: corticofugal control of central auditory sensitivity in the big brown bat, Eptesicus fuscus显示文摘	Sun XD Chen QC Philip HS	1996	Neurosci Letter1996，212，：	1
	7	GDNF: a potent survival factor for motoneurons present in peripheral nerve and muscle 显示文摘	Henderson CE Philips HS Pollock RA	1994	Science1994，266，5187：	1
	8	GDNF:A potent survival factor for motoneurons present in peripheral nerve and muscle显示文摘	Henderson CE Philips HS Pollock RA	1994	Science1994，266，：	1
	9	GDNF:A potent survival factor for motoneurons present in peripheral nerve and muscle显示文摘	Henderson CE Philips HS Pollock RA	1994	Science1994，266，：	1
	10	GDNF:A potent survival factor for motor neurons present in peripheral nerve and musle显示文摘	Henderson CE Philips HS Pollock RA	1994	Science1994，266，5187：	1

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