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| 1 | 介绍《当代隐喻理论:从汉语的视角谈起》显示文摘 | NingYu Amsterdam Philadelphia 李福印 | 2000 | 外语教学与研究2000，32，3： | 13 |
| 2 | Detection of soluble TRAIL in HBV infected patients and its clinical implications显示文摘AIM: To detect the expression of soluble TRAIL (TNF-related apoptosis inducing ligand, TRAIL) in the peripheral blood of HBV infected patients and try to elucidate whether the expression level of sTRAIL have any correlativity with the clinical staging, the expression level of HBV markers and the degree of liver damage.METHODS: 52 cases of HBV infected patients were investigated, induding 8 HBV carriers, 30 chronic hepatitis B, 11 drrhotics and 3 HBV infection related hepatocellular carcinoma. Expression of soluble TRAIL and markers of the hepatitis B were mearsured by enzyme-linked immunosorbent assay.RESULTS: The expression level of sTRAIL in the peripheral blood of the HBV infected patients was significantly higher than that of healthy controls (1378.35±540.23 pg/ml vs 613.75±175.80 pg/ml, P<0.001). In the group of chronic hepatitis, the expression level of sTRAIL was coincident with the status of the disease and was significantly correlated with the level of ALT. In the group of cirrhosis and liver cancer, its expression level was significantly higher than that of the healthy persons and HBV carriers, but lower than that of the hepatitis B patients; meanwhile, the expression of siRAIL did not have any correlativity with the functional indexes of the liver. CONCLUSION: The soluble TRAIL in the HBV infected people may participate in the liver damage. Our results indicated that the expression level of soluble TRAIL may reflect the ravage of liver caused by host immune reaction to a certain degree. | Li-Hui Han Wen-Sheng Sun Chun-Hong Ma Li-Ning Zhang Su-Xia Liu Qiu Zhang Li-Fen Gao,Institute of Immunology,Medical College of Shandong University,Jinan 250012,Shandong Province,China You-Hai Chen,Institute for Human Gene Therapy,University of Pennsylvania,Philadelphia PA 19104,USA | 2002 | World Journal of Gastroenterology2002，8，6： | 12 |
| 3 | Hepatitis B virus X protein modulates the apoptosis of hepatoma cell line induced by TRAIL显示文摘The purpose of this study is to observe the effects of HBx on the apoptosis of hepatoma cells induced by TNF-related apoptosis-inducing ligand (TRAIL) and to study prelimi- nary molecular mechanisms for its effects. In order to set up a model in vitro, BEL7402-HBx cell line, stably expressing HBx mRNA, was established by stable transfection of pcDNA-HBx, which contains HBx gene, into hepatoma cell line BEL7402. Control cell line BEL7402-cDNA3, stably transfected with pcDNA3, was set up simultaneously as a control. Trypan blue exclusion test, caspase 3 activity detection and TUNEL assay were performed to detect the apoptosis of BEL7402, BEL7402-cDNA3, BEL7402-HBx induced by TRAIL. The expression of TRAIL recep- tors in three groups was analyzed by Flow cytometry. In addition, phosphorothioated antisense oligonucleotide against the translation initial region of HBx gene (PS-asODNs/HBx) was used to block the expression of HBx in HepG2.2.15 cells and to further confirm the effects of HBx on TRAIL-induced apoptosis. Trypan blue exclusion test indicated that TRAIL had a dose-dependent cytotoxicity on BEL7402, BEL7402-cDNA3 and BEL7402-HBx cells. Under treatment of the same concentration of TRAIL, BEL7402-HBx had a higher apoptosis rate and a higher level of Caspase 3 activation than BEL7402 and BEL7402-cDNA3. TUENL assay showed that the apoptosis rate of BEL7402-HBx induced by 10 μg/L TRAIL was 41.4%±7.2%, signifi- cantly higher than that of BEL7402 and BEL7402-cDNA3 cells. Blockade of HBx expression in Hep G2.2.15 cells partly inhibited the apoptosis induced by TRAIL. The introduction or blockade of HBx did not change the expression pattern of TRAIL receptors. The present study firstly con- firms the effects of HBx on TRAIL- induced apoptosis from two different points and it is not re- lated with the expression level of TRAIL receptors. This would be useful to further clarify the roles of imbalanced apoptosis in pathogenesis of Hepatitis B and related hepatocellular carcinoma. | LIANG Xiaohong 1 , SUN Wensheng 1 , GAO Lifen 1 , MA Chunhong 1 , HAN Lihui 1 & CHEN Youhai 2 1. Institute of Immunology, Medical School of Shandong University, Jinan 250012, China 2. Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia PA19104, USA | 2005 | Science China(Life Sciences)2005，48，3： | 7 |
| 4 | Cloning of differentially expressed genes in human hepatocellular carcinoma and nontumor liver显示文摘INTRODUCTIONThe mechanism of hepatocellular carcinoma(HCC)is still unclear,although some genes have been found to play a role in the transformation of liver cells,and a variety of studies have described differences in gene expression which distinguished tumor from nontumor[1-6].The new genes,especially the functional genes directly related with tumor are still worth being found.The purpose of our study is to find the different genes between human liver tumor and normal tissues using suppression subtractive hybridization. | Xiao-Yan Cao Jie Liu Zhao-Rui Lian Marcy Clayton Jia-Lu Hu Ming-Hua Zh Dai-Ming Fan Mark Feitelson Institute of Digestive Diseases,Xijing Hospital,Fourth Military Medical University,Xi’an 710033,Shaanxi Province,ChinaDepartment of Pathology & Cell Biology,Thomas Jefferson University,Philadelphia,PA19107 USADepartment of Pathology,Second Military Medical University,Shanghai 200433,China | 2001 | World Journal of Gastroenterology2001，7，4： | 7 |
| 5 | SYNTHESIS OF MESOPOROUS POLY(STYRENE-co-MALEIC ANHYDRIDE)/SILICA HYBRID MATERIALS VIA A NONSURFACTANT-TEMPLATED SOL-GEL PROCESS显示文摘Mesoporous poly (styrene-co-maleic anhydride)/silica hybrid materials have been prepared. The synthesis wasachieved by the HCl-catalyzed sol-gel reactions of tetraethyl orthosilicate (TEOS) and styrene-maleic anhydride copolymerin the presence of 3-aminopropyl triethoxysilane (APTES) as a coupling agent and citric acid as a nonsurfactant template orpore-forming agent, followed by ethanol extraction. Characterization results from nitrogen sorption isotherms and powder X-ray diffraction indicate that polymer-modified mesoporous materials with large specific surface areas (e.g. 900 m^2/g) andpore volumes (e.g. 0.6 cm^3/g) could be prepared. As the citric acid concentration is increased, the specific surface areas, porevolumes and pore diameters of the hybrid materials increase. | Jie-bin Pang Kun-yuan Qiu Yen Wei Department of Polymer Science and Engineering, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China. Department of Chemistry, Drexel University, Philadelphia, Pennsylvania 19104, USA. | 2000 | Chinese Journal of Polymer Science2000，18，5： | 6 |
| 6 | SYNTHESIS OF OLIGO(OXYETHYLENE) MACROMONOMER CARRYING SULFONATE显示文摘This letter reports the synthesis of macromonomers, in which oligo(oxyethylene) chain and sodium salfonate are contained together. This kind of macromonomers has potential application in the fabrication of functional polymers, especially in the study of single-ionic conductors. Some preliminary characterizations of the monomer by IR, IH-NMR, etc. are given as well. | Sheng Shui ZHANG~*, Qing Guo LIU Laboratory of Solid State lonics, University of Science and Technology Beijing, Beijing 100083 Lei Ling YANG Beijing Research Institute of Chemical Industry, Beijing 100013 Gregory C FARRINGTON Department of Materials Science and Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA | 1992 | Chinese Chemical Letters1992，3，10： | 4 |
| 7 | Twinning in Intermetallic Compounds Are Long Shear Vectors and/or Shuffles Really Necessary?显示文摘In this paper the geometric description and general theory of mechanical twinning are reviewed, the twins in general lattices and superlattices are summarized, and the kinetic process by which mechanical twins form is revisited. A case study of mechanical twinning of HfV2+Nb, (cubic) Laves phase, is presented and the synchroshear of selected atomic layers is proposed to explain the physical process of twin formation. If the twins form in this way, then long shear vectors and / or atomicshuffles are not really necessary. | F.M.Chu David P.Pope Dept.of Materials Science and Engineering,University of Pennsylvania,Philadelphia,PA 19104,USA | 1993 | Journal of Materials Science & Technology1993，9，5： | 4 |
| 8 | Multi-Volume CAD Modeling for Heterogeneous ObjectDesign and Fabrication显示文摘1IntroductionWiththeadvancementofdesignandmanufacturingtechnology,theutilizationofintegratedComputer--AidedDesign/Computer-AidedEngineering/Computer-AidedManufacturing,i.e.,CAD/CAE/CAMandrapidprototyping,andtheincorporationofconcurrentengineeringillt... | SUN Wei(Department of Mechanical Engineering and MechanicsDrexel University, Philadelphia, PA 19104, U.S.A.)E-mail: sunwei@drexel.edu or rpdc@drexel.edu | 2000 | Journal of Computer Science & Technology2000，15，1： | 3 |
| 9 | SYNTHESIS AND BIOTECHNOLOGICAL APPLICATIONS OF VINYL POLYMERINORGANIC HYBRID AND MESOPOROUS MATERIALS显示文摘We describe the sol-gel synthesis of a new family of organic-inorganic hybrid materials, in which various vinylpolymers are covalently bonded to and uniformly distributed in inorganic oxide matrices. The materials can be tailored tohave both good toughness and hardness while maintaining excellent optical transparency. Doping the sol-gel metal oxideswith optically active compounds such as D-glucose results in new optical rotatory composite materials. Removal of thedopant compounds from the composites affords mesoporous oxide materials, which represents a new, nonsurfactant-templated route to mesoporous molecular sieves. We have successfully immobilized a series of enzymes and other bioactiveagents in mesoporous materials. Catalytical activities of the enzyme encapsulated in mesoporous materials were found to bemuch higher than those encapsulated in microporous materials. | Yen Wei Kun-yuan Qiu Department of Chemistry, Drexel University, Philadelphia, Pennsylvania 19104, USA Department of Polymer Science and Engineering, Peking University, Beijing 100871, China | 2000 | Chinese Journal of Polymer Science2000，18，1： | 2 |
| 10 | Protective Effects of Dimethyl-4,4'-Dimethoxy-5,6,5',6'-Dimethylene Dioxybiphenyl-2,2'-Dicarboxylate on Damages of Isolated Rat Hepatocytes Induced by Carbon Tetrachloride and D-galactosamine显示文摘The rotective effect of biphenyl dimethyl dicarboxylate(DDB)on chemically induced damages was studied in isolated suspended rat hepatocytes.The experimental results showed that DDB(200μg/10^6cells) efficiently protected the hepatocytes against carbon tetrachloride(CCl4 10mmol·L^-1)and D-galactosamine(1mmol·L^1)induce damages.Membranal lipid peroxidation(malondialdehyde,MDA formation(and glutamic pyruvic transaminase(GPT) release from the hepatocytes were markedly decreased.The damage of the cell surfaces of the hepatocytes were also reduced as seen under a scanning electrom microscope(SEM). Pretreatment with DDB(300mg·kg^-1)orally ameliorated the reduction of liver glycogen and blood glucose caused by ip injection of D-galactosamine(800mg·kg^-1)in mice.When normal rats were given DDB 300mg·kg^-1 once daily for 10d,the free ribosomal protein and RNA in the liver increased significantly.These results indicate that DDB is of beneficial effects on both damaged and normal hepatocytes. | FU TIEBO AND LIU GENGTAODepartment of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences, 1 Xian Nong Tan Street, Beijing 100050,ChinaFox Chase Cancer Center. 7701 Burholme Avenue. Philadelphia, Pennsylvania 19111, USA.To whom correspondence should be addressed. | 1992 | Biomedical and Environmental Sciences1992，5，3： | 2 |
| 11 | Benign chon- droblastoma, in:Dahlin's BoneTumors 显示文摘 | Philadelphia PA Lippincott Raven Unni KK | 1996 | General aspects and data on 11 087 eases1996，，： | 1 |
| 12 | The role of radia- tion therapy in intrahepatic cholangiocarcinoma 显示文摘 | Metz JM Philadelphia Pennsylvania | 2006 | Cancer J2006，12，2： | 1 |
| 13 | Energy detection of unknown deterministic signals显示文摘 | URKOWITZ H PHILADELPHIA P | 1967 | Proceeding of the IEEE1967，55，4： | 1 |
| 14 | Coronary arte-riogra-phy显示文摘 | Braunwald E Philadelphia WB Gensini GG | 1980 | Heart Disease1980，46，2： | 1 |
| 15 | Philadelphia Panel evidence-based clinical practice guidelines on selected rehabilitation interventions for neck pain 显示文摘 | Philadelphia Panel | 2001 | Phys Ther2001，81，10： | 1 |
| 16 | The English Bulldog Model of sleep-disordered breathing显示文摘 | Philadelphia Pennsylvania USA University of Pennsylvania | 1993 | N Engl J Med1993，328，： | 1 |
| 17 | Titanium elastic nails for pediatric femur fractures:a multieenter study of early results with analysis of complications显示文摘 | Study conducted at the Children' s Hospitals of Philadelphia Pennsylvania USA | 2001 | J Pediatr Orthop2001，21，： | 1 |
| 18 | American college of sports medicine (ACSM) 2006显示文摘 | Philadelphia LW Wilkins | 2006 | ACSM'' s guidelines for exercise testing and prescription 2006 ( 7 ) : 233-2352006，，： | 1 |
| 19 | Snail Hosts of Paragonimus in Asia and the Americas显示文摘We have undertaken a comprehensive review of snail hosts of Paragonimus world-wide exclusive of Africa based on modern malacological data, where available, and with consideration of the phylogeny of the snail groups involved. This is the first comprehensive review since those made by Chen (1979) and Chen et al (1983), and there have been considerable taxonomic changes over the past decade. A number of names and concepts found in the medical malacological and parasitological literature up to the present time require revision or correction. There are vast radiations of snails of the superfamilies Cerithiacea and Rissoacea involved in the transmission of Paragonimus in China. We list 54 species world-wide of which 35(65%) occur in China. Revisions and corrections pertaining to China include: (i) The family Hydrobiidae does not occur in China or S.E. Asia,and the Pomatiopsidae should be used. (ii) The genus Bythinella is entirely European (Hydrobiidae: Amnicolinae). The so-called Bythinella of China belongs to the genus Erhaia (Pomatiopsidae). (iii) The generic name Pseudobythinella described from China is preoccupied, a junior synonym of Pseudobythinella Melville 1956, a fossil from England. All Chinese Pseudobythinella are now classified as Erhaia. (iv) Akiyoshia has been used as a generic name for some snails in Hunan transmitting Paragonimus. Akiyoshia is from Japan and biological/ecological data indicate that the Chinese taxon is not Akiyoshia. (v)The genus Tricula in recent Chinese literature is comprised of four genera determined by detailed comparative anatomical data: Tricula, Neotricula, Gammatricula, and Jinhongia.Shells cannot be used to discriminate among them. (vi) Tricula cristella has been consistently misidentified in collections in China and literature. However, genuine T cristella does transmit Paragonimus skrjabini. (vii) Tricula minutoides in the Chinese literature has been misidentified, and specimens are T. crisIella. (viii) The genus Melamia and the family Melaniidae are used in the Chinese literature. The so-called melaniid snails belong to the families Thiaridae, Pleuroceridae, and Melanopsidae. Asian Semisulcospira is pleurocerid while Melanoides and Tarebia are thiarid. (ix) Semisulcospira libertina is correctly identified for populations ranging throughout Japan to Taiwan. This species is most probably not distributed throughout all south China, and intense systematic research on Semisulcospira is needed. A modern classification is given for snails transmitting | G. M. DAVIS CHEN CUI-E KANG ZAI-BIN AND LIU YUE-YING(Academy of Natural Sciences of Philadelphia, 1900 Benjamin Franklin Parkway, Philadelphia, PA 19103, USA Institute of Parasitology,Zhejiang Academy of Medical Sciences, Hangzhou, Zhejiang Province,China | 1994 | Biomedical and Environmental Sciences1994，7，4： | 1 |
| 20 | medicine (ACSM) 2006 显示文摘 | Philadelphia LW Wilkins | 2006 | American college of sports ACSM'' s guidelines for ex-ercise testing and prescription2006，，7： | 1 |
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