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| 1 | 重组脊髓灰质炎病毒用于治疗复发胶质母细胞瘤(英文)显示文摘Background The prognosis of patients with recurrent World Health Organization(WHO)grade IV malignant glioma is dismal,and there is currently no effective therapy.We conducted a dose-finding and toxicity study in this population of patients,evaluating convection-enhanced,intratumoral delivery of the recombinant nonpathogenic polio-rhinovirus chimera(PVSRIPO).PVSRIPO recognizes the poliovirus receptor CD155,which is widely expressed in neoplastic cells of solid tumors and in major components of the tumor microenvironment.Methods We enrolled consecutive adult patients who had recurrent supratentorial WHO grade IV malignant glioma,confirmed on histopathological testing,with measurable disease(contrast-enhancing tumor of≥1 cm and≤5.5 cm in the greatest dimension).The study evaluated seven doses,ranging between 107 and 1010 50%tissue-culture infectious doses(TCID50),first in a dose-escalation phase and then in a dose-expansion phase.Results From May 2012 through May 2017,a total of 61 patients were enrolled and received a dose of PVSRIPO.Dose level-1(5.0×107TCID50)was identified as the phase 2 dose.One dose-limiting toxic effect was observed;a patient in whom dose level 5(1010TCID50)was administered had a grade 4 intracranial hemorrhage immediately after the catheter was removed.To mitigate locoregional inflammation of the infused tumor with prolonged glucocorticoid use,dose level 5 was deescalated to reach the phase 2 dose.In the dose-expansion phase,19%of the patients had a PVSRIPO-related adverse event of grade 3 or higher.Overall survival among the patients who received PVSRIPO reached a plateau of 21%(95%confidence interval,11 to 33)at 24 months that was sustained at 36 months.Conclusions Intratumoral infusion of PVSRIPO in patients with recurrent WHO grade IV malignant glioma confirmed the absence of neurovirulent potential.The survival rate among patients who receivedPVSRIPO immunotherapy was higher at 24 and 36 months than the rate among historical controls. | Desjardins A Gromeier M Herndon JE 2nd Beaubier N Bolognesi DP Friedman AH Friedman HS McSherry F Muscat AM Nair S Peters KB Randazzo D Sampson JH Vlahovic G Harrison WT McLendon RE Ashley D Bigner DD | 2018 | 中华神经外科疾病研究杂志2018，17，4： | 2 |
| 2 | Incidence and configuration of canal systemsin the mesiobuccal root of maxillary first and second molars显示文摘 | Kulid J Peters DD | 1990 | JEndodon1990，16，： | 1 |
| 3 | Incidence and configuration of canal systems in the mesiobuccal root of maxillary first and second molars 显示文摘 | Kulid JC Peters DD | 1990 | J Endod1990，16，7： | 1 |
| 4 | Incidence and configuration of canal systems in the mesiobuccal root of maxillary first and second molars显示文摘 | Kulild JC Peters DD | 1990 | J Endod1990，16，7： | 1 |
| 5 | Incidence and configuration of canal system in the mesiobuccal root of maxillary first and second molars 显示文摘 | Kulid JC Peters DD | 1990 | J Endod1990，16，7： | 1 |
| 6 | A comparison of the area of the canal space occupied by gutta-percha following four gutta- percha obturation techniques using Procosol sealer 显示文摘 | Eguchi DS Peters DD Hollinger JO | 1985 | J Endod1985，11，4： | 1 |
| 7 | Incidence and coni'iguratim of canal systems in the mesiobuccal root of maxillmw first and seeon molars显示文摘 | Kulild JC Peters DD | 1990 | l Endod1990，16，7： | 1 |
| 8 | Microcomputed tomography:An advanced system for detailed endodontic research显示文摘 | Nielsen RB Alyassin AM Peters DD | 1995 | J Endod1995，21，11： | 1 |
| 9 | Incidence and configuration of canal systems in the mesiobuccal root of maxillary first and second molars显示文摘 | Kulild JC Peters DD | 2000 | J Endod2000，16，2： | 1 |
| 10 | Incidence and configuration of canal sys- tems in the mesiobuccal root of maxillary first and second molars 显示文摘 | Kulild JC Peters DD | 1990 | JEndod1990，16，7： | 1 |
| 11 | Negative feedback control of HIF-l through REDDl-regulated ROS suppresses tumor?igenesis显示文摘 | Peter H Crawford AR Vadysirisack DD | 2010 | Proc Natl Acad Sci USA2010，107，10： | 1 |
| 12 | Evidence for diminished levels of epithelial psoriasin and calprotein in chronic rhinosinusitis显示文摘 | Tieu DD Peters AT Carter RT | 2010 | J Allergy Clin Immunol2010，125，3： | 1 |
| 13 | Microcomputedtomography : An advanced system for detailed endodontic re-search显示文摘 | Nielsen RB Alyassin AM Peters DD | 1995 | J Endod1995，21，11： | 1 |
| 14 | Incidence and configuration of canal systems in the mesiobuccal root of maxillary first and second molars显示文摘 | Kulild JC Peters DD | 1990 | J Endod1990，16，7： | 1 |
| 15 | The Perioperative Management of Antithrombotic Therapy-American College of Chest Physicians Evidence-Based Clinical Practice Guidelines ( 8th Edition ) 显示文摘 | James DD Peter BB | 2008 | CHEST2008，133，6： | 1 |
| 16 | Incidence and configuration of canal systems in the mesiobuccal root of maxillary first and second molars显示文摘 | Kulid J Peters DD | 1990 | J Endodon1990，16，： | 1 |
| 17 | Comparison of gutta - percha filling techniques,corspaction(mechnical) ,vertical(warm) , and lateral condensation techniques, Part 1 显示文摘 | Wong M Peters DD Lorton L | 1981 | J Endod1981，7，： | 1 |
| 18 | Incidence and configuration of canal systems in the mesiobuccal root of maxillary first and second molars 显示文摘 | Kulild JC Peters DD | 1990 | J Endod1990，16，7： | 1 |
| 19 | Comparison of gutta-percha filling techniques, compaction (meehnieal), vertical (warm), and lateral condensation techniques, Part 1显示文摘 | Wong M Peters DD Lorton L | 1981 | J Endod1981，7，： | 1 |
| 20 | Prospective navigator correction of image position for coronary MR angiography显示文摘 | Peter DD Michael VM Vaibhav CK | 1997 | Radiology1997，203，： | 1 |
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