|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 全科医学科研的范畴、研究需求和适用方法——《欧洲全科医学/家庭医学和基本医疗保健科研纲要》中文摘译显示文摘本文对《欧洲全科医学/家庭医学和基本医疗保健科研纲要》的中文译稿进行了重点摘登。该文件由欧洲全科医学科研网络制订,包括7部分内容:序言、导言、方法、结果、独立章节,讨论和启示。作为在欧洲发展全科医学科研的核心指南,该文件对欧洲的全科医学学科和科研发展产生了深远的影响。欧洲的全科医学体系和以此为基础而构建的学科理论共识与我国全科医学当前的实际情况可能更为接近。因篇幅所限,本文刊登了其中最重要,对中国研究者也最实用的5部分内容,包括:(1)导言——全科医学的核心能力/特征以及全科医学科研的意义;(2)结果——全科医学的6个核心领域(基本保健管理、'以人为本'的照护、解决具体问题的技能、综合的方法、以社区为导向、整体的方法)的科研范畴,研究需求和适用方法;(3)独立章节——如何发展基本的科研能力和避免常见的科研失误;(4)讨论——未来的全科医学科研重点;(5)启示——科学协会、研究机构、患者参与、科研工作、期刊、科研政策在发展学科方面应注重的问题。因欧洲的全科医学体制和我国较为相似,且存在一定的科研发展代差,该文件在当前阶段也可为我国全科医学研究者所用,基于全科医学学科的视角,从概念、分类学、范围和科研方法等方面,为我国全科医学科研的发展提供参照。 | Eva Hummers-Pradier Martin Beyer Patrick Chevallier Sophia Eilat-Tsanani Christos Lionis Lieve Peremans Davorina Petek Imre Rurik Jean Karl Soler Henri E.J.H.Stoffers Pinar Topsever Mehmet Ungan Paul van Royen Hanny Prick 无 | 2022 | 中国全科医学2022，25，9： | 4 |
| 2 | Reversed-phase fused-core HPLC modeling of peptides显示文摘Different fused-core stationary phase chemistries(C18,Amide,Phenyl-hexyl and Peptide ES-C18) were used for the analysis of 21 structurally representative model peptides.In addition,the effects of the mobile phase composition(ACN or MeOH as organic modifier;formic acid or acetic acid,as acidifying component) on the column selectivity,peak shape and overall chromatographic performance were evaluated.The RP-amide column,combined with a formic acid-acetonitrile based gradient system,performed as best.A peptide reversed-phase retention model is proposed,consisting of 5 variables:log SumAA,log Sv,clog P,log nHDon and log nHAcc.Quantitative structure-retention relationship(QSRR) models were constructed for 16 different chromatographic systems.The accuracy of this peptide retention model was demonstrated by the comparison between predicted and experimentally obtained retention times,explaining on average 86% of the variability.Moreover,using an external set of 5 validation peptides,the predictive power of the model was also demonstrated.This peptide retention model includes the novel in-silico calculated amino acid descriptor,AA,which was calculated from log P,3D-MoRSE,RDF and WHIM descriptors. | Matthias D'Hondt Bert Gevaert Sofie Stalmans Sylvia Van Dorpe Evelien Wynendaele Kathelijne Peremans Christian Burvenich Bart De Spiegeleer | 2013 | Journal of Pharmaceutical Analysis2013，3，2： | 3 |
| 3 | Effects of medeto- midine and ketamine on the regional cerebral blood flow in cats: a SPECT study显示文摘 | Waelbers T Peremans K Vermeire S | 2012 | Vet J2012，192，1： | 1 |
| 4 | A queueing framework for routing problems with time-dependent travel times显示文摘 | Van Woensel T Kerbache L Peremans H | 2007 | Journal of Mathematical Modeling and Algorithms2007，6，1： | 1 |
| 5 | The effect of me- detomidine on the regional cerebral blood flow in dogs meas- ured using Technetium-99m-Ethyl Cysteinate Dimer SPECT 显示文摘 | Waelbers T Peremans K Vermeire S | 2011 | Res Vet Sci2011，91，1： | 1 |
| 6 | Vehicle routing with dynamic travel times: A queueing ap- proach显示文摘 | Van Woensel T Kerbache L Peremans H | 2008 | European Journal of Operational Research2008，186，3： | 1 |
| 7 | Journal of Electron Spectroscopy and Related Phenomena显示文摘 | Maseri F Peremans A Darville J Gilles J M | 1990 | J Electron Spectrosc1990，54，55： | 1 |
| 8 | Vehicle rou- ting with dynamic travel times : a queueing approach 显示文摘 | WOENSEL T V KERBACHE L PEREMANS H | 2008 | European Journal of Operational Research2008，186，3： | 1 |
| 9 | Investigation of the vibrational properties of CN on a Pt electrode by in situ VIS-IR sum frequency generation and functional density calculations显示文摘 | Tadjeddine A Peremans A Le R A | 1996 | Journal of The Chemical Society- Faraday Transactions1996，92，20： | 1 |
| 10 | Risk evaluation of impurities in topical excipients:The acetol case显示文摘Pharmaceutical excipients for topical use may contain impurities,which are often neglected from a toxicity qualification viewpoint.The possible impurities in the most frequently used topical excipients were evaluated in-silico for their toxicity hazard.Acetol,an impurity likely present in different topical pharmaceutical excipients such as propylene glycol and glycerol,was withheld for the evaluation of its health risk after dermal exposure.An ex-vivo in-vitro permeation study using human skin in a Franz Diffusion Cell set-up and GC as quantification methodology showed a significant skin penetration with an overall K_p value of 1.82 × 10^(-3)cm/h.Using these data,limit specifications after application of a dermal pharmaceutical product were estimated.Based on the TTC approach of Cramer class I substances,i.e.1800 μg/(day·person),the toxicity-qualified specification limits of acetol in topical excipients were calculated to be 90 μg/mL and 180 μg/mL for propylene glycol and glycerol,respectively. | Jente Boonen Lieselotte Veryser Lien Taevernier Nathalie Roche Kathelijne Peremans Christian Burvenich Bart De Spiegeleer | 2014 | Journal of Pharmaceutical Analysis2014，4，5： | 1 |
| 11 | Vehicle routing with dynamic travel times: A queueing approach 显示文摘 | Van Woensel T Kerbaehe L Peremans H Vandaele N | 2008 | European Journal of Operational Research2008，168，3： | 1 |
| 12 | The influence of surface defects in methanol dissociative adsorption and CO oxidation on Pt(1<ce:hsp sp='0.12'/>1<ce:hsp sp='0.12'/>0) probed by nonlinear vibrational SFG spectroscopy显示文摘 | F. Vidal A. Tadjeddine C. Humbert L. Dreesen A. Peremans P.A. Thiry B. Busson | 2012 | Journal of Electroanalytical Chemistry2012，，： | 1 |
| 13 | Temperature rise during photo-activated disinfection of root canals 显示文摘 | Dickers B Lamard L Peremans A | 2009 | Lasers Med Sci2009，24，1： | 1 |
| 14 | Vehicle routing with dynamic travel times: a queueing approach显示文摘 | Woensel T V Kerbache L Peremans H | 2008 | European Journal of Operational Research2008，186，3： | 1 |
| 15 | Biomimetic sonar system performing spectrum-based localization 显示文摘 | Reijniers J Peremans H | 2007 | IEEE Transactions on Robotics2007，23，6： | 1 |
| 16 | General practitioners' percep- tion of risk factors for cervical cancer development: consequences for patient e- ducation 显示文摘 | Baay MF Verhoeven V Peremans L | 2006 | Patient Educ Couns2006，62，2： | 1 |
| 17 | Nurse managers' perceptions and ex- periences regarding staff nurse empowerment:A qualitative study 显示文摘 | Bogaert P Peremans L Wit M | 2015 | Front Psychol2015，14，6： | 1 |
| 18 | The Spectrogram Correlation and Transformation Receiver, Revisited显示文摘 | Peremans H Hallam J | 1998 | The Journal of the Acoustical Society of America1998，104，2： | 1 |
| 19 | Interference of iohexol with radioiodine thyroid uptake in the hyperthyroid cat 显示文摘 | Peremans K Vandermeulen E Van Hoek I | 2008 | J Feline Med Surg2008，10，： | 1 |
| 20 | A high resolution sensor based on tri-aural perception显示文摘 | PEREMANS H AUDENAERT K CAMPENHOUT J V | 1993 | IEEE Transactions on Robotics and Automation1993，9，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员