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| 1 | 多光谱视网膜成像与光学相干断层扫描血管技术在非增殖性糖尿病视网膜病变检查中的应用显示文摘目的研究光学相干断层扫描血管(OCTA)和多光谱视网膜成像(MSI)技术在非增殖性糖尿病视网膜病变(NPDR)检查中的应用价值。方法2型糖尿病合并NPDR患者59例118只眼,均行眼底荧光血管造影(FFA)、MSI及OCTA检查。观察并记录所有患眼在FFA、OCTA和MSI图像中微动脉瘤、硬性渗出、棉绒斑、出血4种眼底病变的影像学特征。以FFA检查结果为金标准,对比分析OCTA和MSI两种无创检查方法对上述眼底改变检出的一致性、敏感度、特异度和约登指数。结果与FFA比较,OCTA、MSI对NPDR患眼视网膜微动脉瘤检出均具有较好的一致性(Kappa值分别为0.783和0.815),敏感度分别为98.02%和99.01%,特异度均为76.47%,约登指数分别为74.49%和75.48%;对视网膜硬性渗出,OCTA、MSI均具有较好的一致性(Kappa值分别为0.836和0.891),敏感度分别为94.59%和95.95%,特异度分别为88.64%和93.81%,约登指数分别为83.23%和89.13%;对视网膜棉绒斑,OCTA与FFA一致性较差,MSI与FFA一致性一般(Kappa值分别为0.192和0.467),敏感度分别为75.00%和83.33%,特异度分别为66.98%和87.50%,约登指数分别为41.98%和70.83%;对视网膜出血,OCTA与FFA一致性一般,而MSI与FFA具有较好的一致性(Kappa值分别为0.684和0.906),敏感度分别为93.41%和96.70%,特异度分别为74.07%和96.30%,约登指数分别为67.48%和93.00%。结论OCTA和MSI诊断NPDR患眼微动脉瘤和硬性渗出均有较高的临床价值,MSI较OCTA对诊断视网膜出血诊断更有优势,但OCTA和MSI用于棉绒斑的诊断时应慎重。 | 王莎莎 姜波 Jorge ATrujillo Perdomo 廖荣丰 | 2020 | 天津医药2020，48，11： | 6 |
| 2 | Noninvasive imaging assessment of non-alcoholic fatty liver disease:focus on liver scintigraphy显示文摘Noninvasive diagnoses of nonalcoholic fatty-liver disease(NAFLD) involve the use of serologic markers and imaging methods, such as conventional ultrasonography(US),computed tomography, and magnetic resonance imaging. Although these methods are reliable for the noninvasive detection of moderate to severe fatty changes in the liver, they are not reliable for detecting nonalcoholic steatohepatitis(NASH) and fibrosis. New imaging technologies, such as US-based transient elastography, acoustic radiation force impulse and magnetic resonancebased elastography, can reportedly be used to determine the severity of liver fibrosis associated with NASH. In this context, the field of nuclear medicine through liver scintigraphy has recently been proposed, and is being explored for use in the diagnosis of NASH. More importantly, nuclear medicine may contribute to the distinction between simple steatosis and NASH. For example, the enhanced release of cytokines and the decrease in the phagocytic activity of Kupffer cells play important roles in the pathogenesis of NASH. Removal of technetium-99 m colloid from circulation by Kupffer cell phagocytosis therefore provides a valuable imaging technique. Thus, nuclear medicine is poised to provide useful tools for the evaluation of patients with NAFLD. However, the evidence is still scarce, and more studies with larger samples are needed to identify their role before they are used in clinical practice. | Cristiane Valle Tovo Angelo Zambam de Mattos Gabriela Perdomo Coral Fernanda Schild Branco Eiji Suwa Angelo Alves de Mattos | 2015 | World Journal of Gastroenterology2015，21，15： | 5 |
| 3 | Systematic study of the dependence of magnetic and structural properties of Nd2Fe14B powders on the average particle size显示文摘A systematic study of the magnetic and structural properties dependence on the particle size was realized.For this,commercial NdFeB powder was separated into five different mean particle sizes using sieves.Besides,from the original powder,eleven samples were also produced by mechanical milling assisted by surfactant,using various milling times.A total of sixteen samples were studied by scanning electron microscopy(SEM),X-ray diffraction(XRD),vibrating sample magnetometry(VSM),and Mdssbauer spectrometry(MS).The particle sizes of the samples vary from the micrometer to the nanometer scale.The crystallite size decreases with decreasing particle size.XRD result indicates that the Nd2Fe14B phase is found in all the samples,and the presence of this phase is also corroborated by MS using six sextets for fitting their spectra,with an additional singlet corresponding to the Nd1.1Fe4B4 phase.The mean hyperfine magnetic field increases with increasing particle size because the magnetic dipolar interaction between the magnetic moment of the particles increases with particle size.From the VSM measurements the magnetic energy density(BH)max values were calculated for different particle sizes,and their maximum value of 34.45 MGOe is obtained for the sample with the particle size of 60μm. | J.F.Durán Perdomo G.A.Pérez Alcázar H.D.Colorado J.A.Tabares L.E.Zamora J.J.S.Garitaonandia | 2020 | Journal of Rare Earths2020，38，9： | 3 |
| 4 | Rabeprazole for the prevention of recurrent erosive or ulcerative gastro-oesophageal reflux disease显示文摘 | Charles Birbara Jeffrey Breiter Carlos Perdomo William Hahne | 2000 | European Journal of Gastroenterology & Hepatology2000，，8： | 2 |
| 5 | Primar7 malignam melanoma of tile esophagus: report of case successfullv treated with pre- and post-operative adjuvant hormone-chemolherapy 显示文摘 | Naomoto Y Perdomo JA Kamikawa Y | 1998 | Jpn Clin 0neo11998，28，12： | 1 |
| 6 | Hepatocellular carcinoma in non-alcoholic steatohepatitis without cirrhosis显示文摘Cirrhosis is an emerging major cause of the development of hepatocellular carcinoma(HCC),but in non-alcoholic fatty liver disease(NAFLD),up to 50%of patients with HCC had no clinical or histological evidence of cirrhosis.It is currently challenging to propose general recommendations for screening patients with NAFLD without cirrhosis,and each patient should be evaluated on a caseby-case basis based on the profile of specific risk factors identified.For HCC screening in NAFLD,a valid precision-based screening is needed.Currently,when evaluating this population of patients,the use of non-invasive methods can guide the selection of those who should undergo a screening and surveillance program.Hence,the objective of the present study is to review the epidemiology,the pathophysiology,the histopathological aspects,the current recommendations,and novel perspectives in the surveillance of non-cirrhotic NAFLD-related HCC. | Cristiane Valle Tovo Angelo Zambam de Mattos Gabriela Perdomo Coral Giovana D P Sartori Livia Villela Nogueira Gustavo Tovo Both Cristiane A Villela-Nogueira Angelo A de Mattos | 2023 | World Journal of Gastroenterology2023，29，2： | 1 |
| 7 | Metabolism and elimination of ^14C-donepezil in healthy volunteers: a single-dose study 显示文摘 | TISEO PJ PERDOMO CA FRIEDHOFF LT | 1998 | Br J Clin Pharmacol1998，46，1： | 1 |
| 8 | Chemical and electrochemical conditions on steel under disbonded coatings: the effect of applied potential, solution resistivity, crevice thickness and holiday size显示文摘 | Perdomo J J Song I | 2000 | Corrosion Science2000，42，8： | 1 |
| 9 | Chemical and electrochemical conditions on steel under disbanded coatings:the effect of previously corrode surfaces and wet and dry cycles显示文摘 | J J Perdomo I Song | 2001 | Corrosion Science2001，43，3： | 1 |
| 10 | Integrated acMity and rabcpmzole pharmacolog显示文摘 | Gardner JD Perdomo C Sloan S | 2002 | Aliment Pharmacol Ther2002，16，3： | 1 |
| 11 | Operating theatre sched- uling with patient recovery in both operating rooms and re- covery beds 显示文摘 | Augusto V Xie X L Perdomo V | 2010 | Computers & Industrial Engineering2010，58，2： | 1 |
| 12 | Concurrent administration of donepezil HCl and sertraline HCl in healthy vohmteers: assessment of pharmacokinetic changes and safety following single and multiple oral doses显示文摘 | Nagy CF Kumar D Perdomo CA | 2004 | Br J Clin Pharmacol2004，581，： | 1 |
| 13 | Analysis of the periplasmic proteome of Pseudomonas aeruginosa, a metabolically versatile opportunistic pathogen显示文摘 | IMPERI F CICCOSANTI F PERDOMO A | 2009 | Proteomics2009，9，7： | 1 |
| 14 | Proteomic analysis of fructose induced fatty liver in hamsters显示文摘 | Zhang L Perdomo G Kim DH | 2008 | Metabolism:clinical and experimental2008，57，2： | 1 |
| 15 | Increased beta-oxidation in muscle cells enhances insulin-stimulated glucose metabolism and protects against fatty acid-induced insulin resistance despite intramyoeellular lipid accumulation 显示文摘 | Perdomo G Commerford SR Richard AM | 2004 | J Biol Chem2004，279，27： | 1 |
| 16 | FoxO6 integrates in- sulin signaling with glueoneogenesis in the liver显示文摘 | Kim DH Perdomo G Zhang T | 2011 | Dia- betes2011，60，27： | 1 |
| 17 | Effects of ApoA-V on HDL and VLDL metabolism in APOC3 transgenic mice显示文摘 | Qu Shen Perdomo G Su D | 2007 | J Lipid Research2007，48，7： | 1 |
| 18 | Chemical and electrochemical conditions on steel under disbanded coatings:the effect of applied potential,solution resistivity,crevice thickness,and holiday size显示文摘 | J J Perdomo I Song | 2000 | Corrosion Science2000，42，8： | 1 |
| 19 | Applicability of Superpave hinder testing protocols to modified hinders 显示文摘 | Bahia HU Perdomo D Turner P | 1997 | Transportation Research Record: Journal of the Transportation Research Board1997，1586，1： | 1 |
| 20 | Implica- tion of insulin receptor a isoform and IRA/IGF-IR hybrid recep- tors in the aortic vascular smooth muscle cell proliferation: role of TNF-α and IGF-2显示文摘 | Gomez-Hernandez A Escribano O Perdomo L | 2013 | Endocrinology2013，62，7： | 1 |
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