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| 1 | MicroRNAs as novel predictive biomarkers and therapeutic targets in colorectal cancer显示文摘Colorectal cancer(CRC) is the third most common cancer in western countries. Despite significant improvement in available treatment options, CRC still remains the second leading cause of cancer-related death. Traditionally, 5-fluorouracil has been used as the main chemotherapy drug for treatment of metastatic CRC(mCRC). However, during the last two decades more effective chemotherapeutic agents such as oxaliplatin, irinotecan and the monoclonal antibodies cetuximab, panitumumab and bevacizumab have been used in clinical practice. More recently, the therapeutic armamentarium has been supplemented by the monoclonal antibodies bevacizumab, cetuximab and panitumumab as well as the protein-trap aflibercept and the smallmolecule multi-kinase inhibitor regorafenib. One of the major problems for the management of CRC is the inherent or acquired resistance to therapeutic approaches. The discovery of microRNAs(miRNAs), a class of small, endogenous, non-coding, single-stranded RNAs that play a role as post-transcriptional regulators, has added new dimensions to the diagnosis and treatment of cancer. Because miRNAs are important regulators of carcinogenesis, progression, invasion, angiogenesis and metastases in CRC, they might serve as potential predictive and prognostic factors and even as therapeutic targets themselves. Several miRNAs are already known to be dysregulated in CRCs and have been linked to biological processes involved in tumor progression and response to anti-cancer therapies. This review summarizes current therapeutic approaches for treating CRC and highlights the role of miRNAs as novel predictive biomarkers and potential drug targets in CRC patients. | Verena Stiegelbauer Samantha Perakis Alexander Deutsch Hui Ling Armin Gerger Martin Pichler | 2014 | World Journal of Gastroenterology2014，20，33： | 7 |
| 2 | Optimal bidding in online auctions 显示文摘 | BERTSIMAS D HAWKINS J PERAKIS G | 2009 | Journal of Revenue & Pricing Management2009，8，1： | 1 |
| 3 | Nitrogen loss from unpolluted South American forestsmainly via dis- solved organic compounds 显示文摘 | Steven S Perakis Lars O | 2002 | Nature2002，415，24： | 1 |
| 4 | Nitrogen retentionacross a gradient of SN additions to an unpolluted temperate forest soil in Chile显示文摘 | PERAKIS S S COMPTON J E HEDIN L O | 2005 | Eco Soc America2005，86，1： | 1 |
| 5 | Outcomes and efficacy of newborn hearing screening: strengths and weaknesses (success or failure? ) 显示文摘 | Korres S Nikolopoulos TP Peraki EE | 2008 | Laryngoscope2008，118，7： | 1 |
| 6 | Supercritical fluid extraction of black pepper oil显示文摘 | Perakis C Louli V Magoulas K | | 0，，04： | 1 |
| 7 | Nitrogen loss from unpolluted South American forests mainly via dissolved organic compounds 显示文摘 | Perakis S S Hedln L O | 2002 | Nature2002，415，： | 1 |
| 8 | Competitive multi-period pricing for perishable products:A robust optimization approach 显示文摘 | Perakis G and Sood A | 2006 | Mathematical Programming2006，107，12： | 1 |
| 9 | Regret in the newsvendor model with partial information显示文摘 | Perakis G Roels G | 2008 | Operations Research2008，56，1： | 1 |
| 10 | Assessment of crop damage using space remote sensing and GIS显示文摘 | Silleos N Perakis K Petsanis G | 2002 | 23(3):417-4272002，23，3： | 1 |
| 11 | Optimal liner fleet routeing strategies显示文摘 | Cho S C Perakis A N | 1996 | Maritime Policy and Management1996，23，3： | 1 |
| 12 | Supercritical CO2 extraction of dittany oil:experiments and modeling显示文摘 | PERAKIS C LOULI V VOUTSAS E | | 0，，02： | 1 |
| 13 | Nitrogen loss from unpolluted South American forests mainly via dissolved organic compounds显示文摘 | Perakis S S Hedin L O | 2002 | Nature2002，415，： | 1 |
| 14 | Peritoneal dialy- sis as-sociated peril:clinical features and predictors of outcome 显示文摘 | Kofteridis DP Valachis A Perakis K | 2010 | Int J Infect Dis2010，14，6： | 1 |
| 15 | Using Facial Symmetry to Handle Pose Variations in Real-World 3D Face Recognition显示文摘 | Georgios Passalis Panagiotis Perakis Theoharis Theoharis | 2011 | IEEE Transactions on Pattern Analysis and Machine Intelligence2011，，10： | 1 |
| 16 | Nitrogen loss from unpolluted south American forests mainly via dissolved organic compounds显示文摘 | Perakis S S Hedin L O | 2002 | Nature2002，415，： | 1 |
| 17 | Assessment of Crop Damage Using Space Remote Sensing and GIS显示文摘 | Silleos N Perakis K Petsanis G | 2002 | International Journal of Remote Sensing2002，23，3： | 1 |
| 18 | Optimal liner fleet routing strategies显示文摘 | Cho S C Perakis A N | 1996 | Maritime Policy&Management1996，23，3： | 1 |
| 19 | Use of 3G mobile phone links for teleeonsultation between a moving ambulanee and a hospital base station显示文摘 | Banitsas K A Perakis K Tachakra S | 2006 | Journal of Telemedicine and Teleeare2006，12，1： | 1 |
| 20 | Optimal liner fleet routeing strategies显示文摘 | CHO S C PERAKIS A N | 1996 | Maritime Policy and Management1996，23，3： | 1 |
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