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| 1 | Impact of Sea-Level-Rise and Human Activities in Coastal Regions:An Overview显示文摘Coastal regions are becoming increasingly vulnerable to flooding because of accelerating sea-level-rise(SLR),local ground subsidence,and the changes in topography and morphology.Moreover,coastal areas are usually highly urbanized and increased human activities have an effect on the stability and preservation of the environment.For instance,the growing demand for new lands to accommodate the population and the industrial facilities in China has required the design and the deployment of land-reclamation projects from the ocean,with a marked impact on fragile coastal eco-systems.Specifically,the Yangtze River and Pearl River Estuary,two major estuaries of the world,have long been subject to intensive human activities over the past decades.Long-term ground subsidence evolution,topographic changes,and morphological variation of the coastal regions have drawn great attention.This paper provides an overview of well-established Earth Observation(EO)remote sensing(RS)technologies that are employed to continuously monitor the changes of urbanized regions.The combined use of EO-based DInSAR analyses along with the knowledge of the geomorphology of the coastal regions allows a more precise picture of the SLR risk in the investigated coastal regions.In this paper,we will concentrate on remote sensing technologies that allow the gathering of heterogeneous information,such as those based on the use of synthetic aperture radar(SAR),satellite altimeters and tide gauge data.We will underline how human activities trigger changes in the living environment of coastal zones and the associated risks for the population.Observed coastline changes,coastal regions terrain subsidence,and offshore bathymetry have a pronounced effect on the increasing risk of flooding.Accordingly,we also present insights into some inundation model projections employed for evaluating the potential flooding risk in coastal regions. | Qing ZHAO Antonio PEPE Adam DEVLIN Shuangshang ZHANG Francesco FALABELLA Giovanni ZENI Qiang WANG Jingzhao DING Danan DONG Min LIU Qing XU Xia LEI Jiayi PAN | 2021 | Journal of Geodesy and Geoinformation Science2021，4，1： | 5 |
| 2 | Early gastric cancer:A challenge in Western countries显示文摘Early gastric cancer(EGC)is an invasive carcinoma involving only the stomach mucosa or submucosa,independently of lymph node status.EGC represents over 50%of cases in Japan and in South Korea,whereas it accounts only for approximately 20%of all newly diagnosed gastric cancers in Western countries.The main classification systems of EGC are the Vienna histopathologic classification and the Paris endoscopic classification of polypoid and non-polypoid lesions.A careful endoscopic assessment is fundamental to establish the best treatment of EGC.Generally,EGCs are curable if the lesion is completely removed by endoscopic resection or surgery.Some types of EGC can be resected endoscopically;for others the most appropriate treatment is surgical resection and D2 lymphadenectomy,especially in Western countries.The favorable oncological prognosis,the extended lymphadenectomy and the reconstruction of the intestinal continuity that excludes the duodenum make the prophylactic cholecystectomy mandatory to avoid the onset of biliary complications. | Maria Michela Chiarello Valeria Fico Gilda Pepe Giuseppe Tropeano Neill James Adams Gaia Altieri Giuseppe Brisinda | 2022 | World Journal of Gastroenterology2022，28，7： | 3 |
| 3 | Revisiting the Clinical Value of 18F-FDG PET/CT in Detection of Recurrent Epithelial Ovarian Carcinomas: Correlation With Histology, Serum CA-125 Assay, and Conventional Radiological Modalities显示文摘 | Lidija Antunovic Marino Cimitan Eugenio Borsatti Tanja Baresic Roberto Sorio Giorgio Giorda Agostino Steffan Luca Balestreri Rosa Tatta Giovanna Pepe Domenico Rubello Diego Cecchin Vincenzo Canzonieri | 2012 | Clinical Nuclear Medicine2012，，： | 3 |
| 4 | Acetabular components with or without screws in total hip arthroplasty显示文摘AIM To compare the operation time, blood loss, and early outcomes of acetabular components with and without the screw.METHODS Thirty patients who underwent cementless acetabular component with or without screw and whose follow-up exceeded one year period in total hip arthroplasty were evaluated. A posterior approach was used in all surgical procedures by one experienced surgeon. Demographic data, operation time, intra-and postoperative blood loss volume, follow-up clinical score, cup migration, and osteolysis were recorded. The Kolmogorov-Smirnov test was performed for testing the normality of study data. Mann-Whitney U test was used to analyze the intergroup differences. A P-value of ≤ 0.05 was considered statistically significant.RESULTS Acetabular components were used in 16(53.3%) patients with screw and 14(46.7%) without screw. After one year of follow-up, an osteolytic lesion of 3 mm was found in only one patient in the screw group. No cup migrationwas encountered. Intra-group mean Harris hip score significantly increased, but there was no significant intergroup difference. While the mean operation time of the screw group was 121.8 min(range; 95-140), it was 102.7 min(range; 80-120) in the no-screw group, and this difference was statistically significant(P = 0.002). The mean intraoperative/postoperative, and total blood loss were 556.6 mL(range: 350-800)/423.3 mL(range: 250-600), and 983.3 mL(range: 600-1350), respectively in the screw group; and 527 mL(range: 400-700)/456 mL(range: 230-600), and 983 mL(range: 630-1250), respectively in the no-screw group. The blood loss difference between the two groups was not significant. In the screw group, the operation time was 19.1 min longer than the no-screw group, and this difference was statistically significant.CONCLUSION Acetabular components with or without screw have similar results, but the use of screw increases the operation time significantly, while not changing the blood loss volume. | Murad Pepe Onur Kocadal Tamer Erener Kubilay Ceritoglu Ertugrul Aksahin Cem Nuri Aktekin | 2017 | World Journal of Orthopedics2017，8，9： | 2 |
| 5 | Therapeutic strategies in Crohn’s disease in an emergency surgical setting显示文摘Crohn’s disease(CD)remains a chronic,incurable disorder that presents unique challenges to the surgeon.Multiple factors must be considered to allow development of an appropriate treatment plan.Medical therapy often precedes or complements the surgical management.The indications for operative management of CD include acute and chronic disease complications and failed medical therapy.Elective surgery comes into play when patients are refractory to medical treatment if they have an obstructive phenotype.Toxic colitis,acute obstruction,perforation,acute abscess,or massive hemorrhage represent indications for emergency surgery.These patients are generally in critical conditions and present with intra-abdominal sepsis and a preoperative status of immunosuppression and malnutrition that exposes them to a higher risk of complications and mortality.A multidisciplinary team including surgeons,gastroenterologists,radiologists,nutritional support services,and enterostomal therapists are required for optimal patient care and decision making.Management of each emergency should be individualized based on patient age,disease type and duration,and patient goals of care.Moreover,the recurrent nature of disease mandates that we continue searching for innovative medical therapies and operative techniques that reduce the need to repeat surgical operations.In this review,we aimed to discuss the acute complications of CD and their treatment. | Maria Michela Chiarello Gilda Pepe Valeria Fico Valentina Bianchi Giuseppe Tropeano Gaia Altieri Giuseppe Brisinda | 2022 | World Journal of Gastroenterology2022，28，18： | 2 |
| 6 | The use of a standardized Chinese herbal formula in patients with advanced lung cancer:a feasibility study显示文摘Objective: Increasing numbers of cancer patients are using Chinese herbs(CHs). However, differences among prior studies make it difficult to draw firm conclusions about the clinical usefulness of any specific CH formula. The primary objective of this study was to establish the acceptability of taking a standardized CH formula for patients with advanced lung cancer. The secondary objective was to identify any toxicities attributable to this CH formula and to measure changes in quality of life.Methods: A single-arm, prospective study of a 6-week intervention with a selected CH formula in15 patients with stage 4 nonsmall-cell lung cancer(NSCLC, Seventh American Joint Committee on Cancer TNM staging system).Results: Patients with advanced lung cancer were interested in using the CH formula. Completion(93%)and adherence(98%) levels were very high and most patients perceived the CH treatment as easy to take and were willing to take the CHs used in the study again if it was available. About half of the patients reported adverse events, all of which were mild(Grade 1 or 2) and only a small minority(8%) were potentially related to CHs. No biochemical or hematological evidence of toxicity was observed. Overall, there were improvement in quality of life, and reduced feelings of tiredness and sleepiness.Conclusion: This study provides preliminary evidence that short-term use of a carefully selected and prepared CH formula in patients with stage 4 NSCLC is acceptable and safe. | Goulnar Kasymjanova Anh-Thi Tran Victor Cohen Carmela Pepe Lama Sakr David Small Jason Scott Agulnik Robert Thomas Jagoe | 2018 | Journal of Integrative Medicine2018，16，6： | 2 |
| 7 | Cerium hybrid silica coatings on stainless steel AISI 304 substrate显示文摘 | PEPE A APARICIO M DURAN A | 2006 | Journal of Sol-Gel Science and Technology2006，39，2： | 1 |
| 8 | Inference using surrogate outcome data and a validation sample显示文摘 | Pepe M S | 1992 | Biometrika1992，79，2： | 1 |
| 9 | A prospective,population-based study of the demographics,epidemiology,management,and outcome of out-of-hospital pediatric cardiopulmonary arrest显示文摘 | Sirbaugh PE Pepe PE Shook JE | 1999 | Ann Emerg Med1999，32，2： | 1 |
| 10 | Immediate versus delayed fluid resuscitation for hepotensive patients with penetrating torso injuries显示文摘 | Bickell WH Wall MJ Pepe PE | 1994 | New EngJ Med1994，331，17： | 1 |
| 11 | Immediate versus delayed fluid resuscitation for hypotensive patients with penetrating torso injuries 显示文摘 | Biekell W H Wall M J Jr Pepe P E | 1994 | N Engl J Med1994，331，17： | 1 |
| 12 | Paticnts with know or suspected lung cancer:cvluation of clinical management changes due to 18aF-fluorodeoxyglucose positron emission tomography (18 F-FDG PET) study显示文摘 | Pepe G Rossetti C Sironi S | | 0，，09： | 1 |
| 13 | Observational study on preoperative surgical field disinfection: povidone-iodine and chlorhexidine-alcohol显示文摘 | Magalini S Pepe G Panunzi S | 2013 | Eur Rev Med Pharmacol Sci2013，17，24： | 1 |
| 14 | Phases of biomarker development for early detection of cancer显示文摘 | Pepe MS Etzionl R Feng Z | 2001 | J Natl Cancer Inst2001，93，14： | 1 |
| 15 | The effect of EDTA and citric acid on phytoremediation of Cd, Cr, and Ni from soil using Helianthus annuus 显示文摘 | Turgut C Pepe K M Cutright T J | 2004 | Environmental Pollution2004，131，1： | 1 |
| 16 | 16S-23S rDNA inter-genic spacer region polymorphism of Lactococcus garvieae, Lactococcus raffinolactis and Lactococcus revealed by PCR and nucleotide sequence analysis显示文摘 | Blaiotta G Pepe O Mauriello G | 2002 | Syst Appl Microbi-ol2002，25，4： | 1 |
| 17 | Immediate versus delayed fluid resuscitation for hypotensive patients with penetrating torso injuries显示文摘 | Wall MJ Pepe PE | 1994 | New Eng J Med1994，331，： | 1 |
| 18 | Energy deficiency in the failure heart:Linking increased reactive oxygen species and discruption of oxidative phosphorylation rate显示文摘 | Sheeran FL PePe S | 2006 | Biochem Blophys Acta2006，1757，： | 1 |
| 19 | From Artifacts to Aggregations: Modeling Scientific Life Cycles on the Semantic Web 显示文摘 | Pepe A Mayernik M Borgman C L | 2010 | Journal of the American Society for Information Science and Technology2010，3，61： | 1 |
| 20 | Using the ROC curve for gauging treatment effect in clinical trials显示文摘 | Brumback LC Pepe MS Alonzo TA | 2006 | Stat Med2006，25，4： | 1 |
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