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| 1 | Synthesis and Insecticidal Evaluation of Novel Anthranilic Diamides Derivatives Containing 4-Chlorine Substituted N-Pyridylpyrazole显示文摘To search for potent insecticides targeting at ryanodine receptors(RyRs),a series of novel anthranilic diamides analogs containing 4-chlorine N-pyridylpyrazole were designed and synthesized.Their insecticidal activities were evaluated and the preliminary struc ture-activity relationships(SARs)were discussed.The insecticidal results showed that some of the compounds(8a-8h,8m,8n)exhibited good larvicidal activities against oriental armyworm at 2.5 mg·L^(-1),and compound 8m possessed 60%insecticidal activityat 0.5 mg·L^(-1).For diamondback moth,8m exhibited better activity than Chlorantraniliprole at a hundred fold preference. | Huangong Li Yangyang Zhao Pengwei Sun Li Gao Yuxin Li Lixia Xiong Na Yang Sha Zhou Zhengming Li | 2021 | Chinese Journal of Chemistry2021，39，1： | 3 |
| 2 | Design,Synthesis,Biological Evaluation and SARs of Anthranilic Diamide Derivatives Containing Pyrrole Moieties显示文摘In order to find a new variety of ryanodine receptor(RyR)regulator with greater biological activity,a se-ries of anthranilic diamide derivatives possessing pyrrole structure was designed and synthesized in this study.The pyrrole derivatives were evaluated for their insecticidal activity against Mythimna separata and Plutella xylostella.As indicated by the preliminary biological activities,compounds 12h-12j and 121-12n exhibited a remarkable in-secticidal activity against M.separata at 0.25 mg/L.Compared to control chlorantraniliprole.compound 12i exhibited more excellent insecticidal activity at 0.1 mg/L.Meanwhile,compounds 12c,12h,12i.12j.121,and 12m were selected to test the insecticidal activity against P xylostella,which led to the desirable insecticidal activity at 1x103 mg/L.Notably,compound 121 demonstrated 47%insecticidal activity at 5×10^(-6) mg/L over the control.In addition,the biological mechanism of action of compound 12i was investigated by means of insect clectrophysiology experiment. | ZHAO Yangyang LI Huangong SUN Pengwei GAO Li ZHOU Sha XIONG Lixia YANG Na LI Yuxin LI Zhengming | 2020 | Chemical Research in Chinese Universities2020，36，6： | 0 |
| 3 | Adhesion and corrosion resistance of polycaprolactone coating on NiTi alloy surface after alkali heat pretreatment显示文摘Selective laser melting of nickel-titanium alloy(SLM-NiTi)can precisely control the size of the sample molding structure and has attracted extensive attention due to its special superelasticity and shape memory effect.However,the biological inertness and poor corrosion resistance of SLM-NiTi alloy limit their wide application as biomedical implant materials.In this study,polycaprolactone(PCL)coating was prepared on SLM-NiTi alloy by dipping and pulling method,and the effects of alkali heat pretreatment on the morphology,adhesion,corrosion resistance,long-term stability and biomineralisation of the PCL coatings were investigated.The results showed that PCL coating can substan-tially improve the performance of SLM-NiTi alloy,and the PCL coating after alkali heat pretreatment has higher adhesion(increased from 1,747 to 2,498 mN)and lower corrosion current density(reduced by about an order of magnitude compared to PCL coating alone).In addition,the necessary stability,biomineralisation and biocompatibility ability of coatings were also further improved.Therefore,the alkali heat pretreated PCL-coated SLM-NiTi alloy has good application prospects in implants due to its superior properties. | Zhihui Zhang Yanan Yang Yunting Guo Pengwei Sha Zezhou Xu Zhenglei Yu Jiashun Si Zhengao Zhang Jia Guo Yifan Chen | 2022 | Biosurface and Biotribology2022，8，4： | 0 |
| 4 | Targeted Synthesis of Anthranilic Diamides Insecticides Containing Trifluoroethoxyl Phenylpyrazole显示文摘A series of novel anthranilic diamides analogues(9a-9t)containing trifluoroethoxyl pyrazole moiety was designed and synthesized and their insecticidal bioactivities against Mythimna separata(Walker,M.separata)and Plutellaxylostella(P.xylostella)were evaluated.The structures of the title compounds were confirmed by^(1)H NMR,^(13)C NMR and HRMS.Preliminary insecticidal activities showed that some of the title compounds possessed good to excellent bioactivities towards M.separata and P.xylostella.Compounds 9c and 9t exhibited 100%mortality rate against M.separate at 0.2 mg/L.For the P.xylostella,the synthesized compounds(9c-9e,9i and 9o)showed 70%,80%,75%,65%and 60%insecticidal activities at 1×10^(−6)mg/L,respectively,higher than that of chlorantraniliprole(0).Based on excellent insecticidal activities,the mode of the action was tested by the calcium-imaging technique,the results of which demonstrated that the novel compounds shared the same target with chlorantraniliprole.The binding pose of the most active compound 9t in RyRs of P.xylostella was predicted by molecular docking,which showed that compound 9t interacted with the residues Glu140(A)and His147(A)via hydrogen bond. | LI Huangong ZHAO Yangyang SUN Pengwei GAO Li XIONG Lixia YANG Na ZHOU Sha LI Yuxin LI Zhengming | 2021 | Chemical Research in Chinese Universities2021，37，3： | 0 |
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