|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 左氧氟沙星、加替沙星及莫西沙星对肺结核患者的早期及延长早期杀菌活性显示文摘目的:评估左氧氟沙星、加替沙星及莫西沙星等新氟喹诺酮类药物对肺结核患者的早期杀菌活性及延长早期杀菌活性。设计:随机开放临床试验。40例成年新诊断的涂阳肺结核患者(每组10例)分别每日单一接受异烟肼300mg,或左氧氟沙星1000mg,或加替沙星400mg,或莫西沙星400mg的7天治疗。治疗前2天及单药治疗7天期间,每日收集痰液进行定量培养。计量单药治疗开始的头2天(0-2天)及治疗后5天(2-7天)的菌量下降情况,以评估各药的早期及延长早期杀菌活性。对实验室工作人员关于病人治疗分组信息采用单盲法。结果:异烟肼的早期杀菌活性为0.67log10cfu/毫升/天,高于莫西沙星(0.33log10cfu/毫升/天)及加替沙星(0.35log10cfu/毫升/天)。与每日1000mg左氧氟沙星的早期杀菌活性(0.45log10cfu/毫升/天)相比,无统计学差异(P=0.14)。3种氟喹诺酮类药物的早期杀菌活性(0-2天)与延长早期杀菌活性(2-7天)相似。总体说来,氟喹诺酮类药物的延长早期杀菌活性高于异烟肼。结论:莫西沙星、加替沙星及高剂量左氧氟沙星,虽然略低于异烟肼,但均有良好的早期杀菌活性,并具有较高的延长早期杀菌活性。有理由对这些药物敏感的结核病人进行进一步的治疗研究。 | J. L. Johnson D. J. Hadad W. H. Boom C. L. Daley C. A. Peloquin K. D. Eisenach D. D. Jankus S. M. Debanne E. D. Charlebois E. Maciel M. Palaci R. Dietzet 马玙(译) 屠德华(校) 张立兴(审) | 2006 | 国际结核病与肺部疾病杂志2006，1，2： | 5 |
| 2 | Population pharmacokinetics of Levofloxacin,Gat- ifloxacin,and moxifloxacin in adults with pulmonary tuberculosis 显示文摘 | PELOQUIN C A HADAD D J MOLINOL P D et al | 2008 | Antimicrob Agents Chemother2008，53，： | 1 |
| 3 | Breeding potatoes for developing countries using wild tuber bearing Solanum spp and ploidy manipulation显示文摘 | M Iwanaga S J Peloquin | 1994 | J Genet and Breed1994，48，： | 1 |
| 4 | Laboratory study of the influence of prey size on vulnerability to cannibalism in snow crab Chinonoecetes opilio ( Fabricius 1780) 显示文摘 | Dutil J D Munro J Peloquin M | 1997 | Journal of Experimental Marine Biology and Ecology1997，14，： | 1 |
| 5 | Limited Sampling Strategy and Target Attainment Analysis for Levoflox- acin in Patients withTuberculosis 显示文摘 | Alsultan A An G Peloquin CA | 2015 | Antimierob A- gents Chemother2015，59，7： | 1 |
| 6 | Bilateral sexual polyploidization in potatoes显示文摘 | Mendiburu A O Peloquin S J | 1977 | Euphytica1977，26，： | 1 |
| 7 | Functional endoscopic sinus surgery and 109 mycetomas of paranasal sinuses显示文摘 | Klossek JM Serrano E Peloquin L | 1997 | Laryngoscope1997，107，1： | 1 |
| 8 | Isolation and identification of bacteria associated with adult laboratory Mexican fruit flies, Anastrepha ludens (Diptera: Tephritidae)显示文摘 | Kuzina LV Peloquin JJ Vacek DC | 2001 | Current Microbiology2001，42，4： | 1 |
| 9 | A new neurological fo-cus in neonatal intensive care 显示文摘 | Bonifacio SL Glass HC Peloquin S | 2011 | Nat Rev Neuro2011，7，9： | 1 |
| 10 | The significance of genic balance to endosperm development in interspecific crosses显示文摘 | S. A. Johnston T. P. M. Nijs S. J. Peloquin R. E. Hanneman | 1980 | Theoretical and Applied Genetics1980，，1： | 1 |
| 11 | Comparative pharmacokinefics and pharmacodynamics of the rifamycin antibacterials显示文摘 | Burman WJ Gallicano K Peloquin C | 2001 | Clin Pharmacokinetics2001，40，： | 1 |
| 12 | Population Pharmaeokineties and its Role in Anti-tuberculosis Drug Development & Optimization of Treatment 显示文摘 | Egelund E F Barth A B Peloquin C A | 2011 | Curr Pharm Des2011，17，27： | 1 |
| 13 | The significance of genic balance to endosperm development in interspecific crosses显示文摘 | T P M den Nijs S J Peloquin | 1980 | Theor Appl Genet1980，57，： | 1 |
| 14 | Cloning and Expression of the Polychlorinated Biphenyl-Degradation Gene Cluster from Arthrobacter M5and Comparison to Analogous Genes from Gram-Negative Bacteria显示文摘 | Peloquin L Greer C W | 1993 | Gene1993，125，1： | 1 |
| 15 | Paired-pulse depression of excitatory postsynaptic current sinks in hippocampal CA1 in vivo 显示文摘 | Leung LS Peloquin P Canning KJ | 2008 | Hippocampus2008，18，10： | 1 |
| 16 | Cloning and expression of the polychlorinated biphenyl-degradation gene cluster from Arthrobacter M5 and comparison to analogous genes from gram-negative bacteria 显示文摘 | Peloquin L Greer C W | 1993 | Gene1993，125，1： | 1 |
| 17 | Physiology of the entorhinal and perirhinal projections to the hippocampus studied by current source density analysis显示文摘 | Canning K J Wu K Peloquin P | 2000 | Ann N Y Acad Sci2000，911，： | 1 |
| 18 | Functional endoscopic sinus surgery and 109 mycetoma of paranasal sinuses显示文摘 | Klossek JM Serrano E Peloquin L | 1997 | Laryngosc ope1997，107，： | 1 |
| 19 | Anti-Inflammatory effects of the macrolides 显示文摘 | DAVIDSON R PELOQUIN L | 2002 | J Otolaryngol2002，31，1： | 1 |
| 20 | Paired-pulse depression of excitatory postsynaptic current sinks in hippocampal CA1 in vivo显示文摘 | Leung LS Peloquin P Canning KJ | 2008 | Hippocampus2008，18，10： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员