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| 1 | Distribution and effects of polymorphic RANTES gene alleles in HIV/HCV coinfection - A prospective cross-sectional study显示文摘AIM: Chemokines and their receptors are crucial for immune responses in HCV and HIV infection. RANTES gene polymorphisms lead to altered gene expression and influence the natural course of HIV infection. Therefore,these mutations may also affect the course of HIV/HCV coinfection.METHODS: We determined allele frequencies of RANTES-403 (G→A), RANTES-28 (C→G) and RANTESIN1.1 (T→C) polymorphisms using real-time PCR and hybridization probes in patients with HIV (n = 85), HCV (n= 112), HIV/HCV coinfection (n = 121), and 109 healthy controls. Furthermore, HIV and HCV loads as well as CD4+ and CD8+ cell counts were compared between different RANTES genotypes.RESULTS: Frequencies of RANTES-403 A, RANTES-28 G and RANTES-IN1.1 C alleles were higher in HIV infected patients than in healthy controls (-403: 28.2% vs 15.1%,P = 0.002; -28: 5.4% vs 2.8%, not significant; IN1.1:19.0% vs 11.0%, P = 0.038). In HIV/HCV coinfected patients, these RANTES alleles were less frequent than in patients with HIV infection alone (15.4% P = 0.002;1.7%; P = 0.048; 12.0%; not significant). Frequencies of these alleles were not significantly different between HIV/HCV positive patients, HCV positive patients and healthy controls.CONCLUSION: All three RANTES polymorphisms showed increased frequencies of the variant allele exclusively in patients with HIV monoinfection. The finding that the frequencies of these alleles remained unaltered in HIV/HCV coinfected patients suggests that HCV coinfection interferes with selection processes associated with these alleles in HIV infection. | Golo Ahlenstiel Agathe Iwan Jacob Nattermann Karin Bueren Jürgen K Rockstroh Hans H Brackmann Bernd Kupfer Olfert Landt Amnon Peled Tilman Sauerbruch Ulrich Spengler Rainer P Woitas | 2005 | World Journal of Gastroenterology2005，11，48： | 3 |
| 2 | The chemokine SDF-1 stimulates integrin-mediated arrest of CD34(+) cells on vascular endothelium under shear flow.显示文摘 | Peled A Petit I Kollet O | | 0，，： | 3 |
| 3 | Requirement for cyclin D3 in germinal center formation and function显示文摘第二等的淋巴的纸巾的幼芽的中心(GC ) 对装高亲密关系的体液的有免疫力的回答批评。当多样化他们的抗体基因时,在 GC 以内的 B 房间经历快速的同种细胞的扩大和选择。尽管 GC B 房间采用一个唯一的 proliferative 程序提供这些进程,这通常被相信,很少联系 GC 的房间周期怎么被安排被知道。D 类型 cyclins 组成使房间能对生理的变化作出回应的房间周期引擎的一个重要部件。房间类型 -- 并且 D 类型 cyclins 的发展阶段特定的角色被描述了,但是 cyclin D 要求没在 GC 反应期间被探讨。在这研究,我们报导 cyclin D3 为切换的增长和 Ig 班大部分是非必需的在 vitro 激活的 B 房间。相反,在 Ccnd3 的 GC 开发 ?/ ?老鼠显著地被损害,作为是 T 房间依赖者抗体反应。在 GC 以内,尽管切换, unswitched B 房间被 cyclin D3 inactivation 影响, IgM?水池更严重地被减少。有趣地尽管有 cyclin D2 表示的补偿增加, Ccnd3 的一个重要数字 ?/ ?GC B 房间处于静止 G0 状态积累。最后,尽管 cyclin D3 inactivation 没在 GC B 房间破坏 BCL6 表示,支持 BCL6 overexpression 的效果完全堵住了 GC,建议 cyclin D3 调整 GC 形成的 BCL6 下游地行动。这是 cyclin D3 玩的第一示范在 B 房间开发的 GC 阶段的一个重要、唯一的角色。 | Jonathan U Peled J Jessica Yu Jeganathan Venkatesh Enguang Bi B Belinda Ding Melissa Krupski-Downs Rita Shaknovich Piotr Sicinski Betty Diamond Matthew D Scharff B Hilda Ye | 2010 | Cell Research2010，20，6： | 3 |
| 4 | The use of Pillcam Colon in assessing mucosal inflammation in ulcerative colitis: a multicenter study显示文摘 | J. Sung K. Ho H. Chiu J. Ching S. Travis R. Peled | 2012 | Endoscopy2012，，08： | 2 |
| 5 | Advanced Polymer Electrolytes for High-energy-density Power Sources显示文摘 | D. Golodnitsky E. Livshits R. Kovarsky E. Peled | 2005 | 复旦学报(自然科学版)2005，44，5： | 2 |
| 6 | Cooperatation between p53-dependent and p53-indepen-dent apototic pathways in myeloid cells显示文摘 | Peled A Zipori D Rotter V | 1996 | Cancer Res1996，569，9： | 1 |
| 7 | Confinement of damaged and non-damaged struc rural concrete with FRP and TRC sleeves显示文摘 | PELED A | 2007 | Journal of Corn posites for Construction2007，11，5： | 1 |
| 8 | CXCR4 antagonists: targeting the mi- croenvironment in leukemia and other cancers 显示文摘 | Burger JA Peled A | 2009 | Leukemia2009，23，1： | 1 |
| 9 | Enhancing the take of injected adipose tissue by a sim pie method for concent rating fat cells显示文摘 | Ramon Y Shoshani O Peled IJ | 2005 | Plast Reconstr Surg2005，115，1： | 1 |
| 10 | Prevention of distortion of vascular deprivation-induced osteoneerosis of the rat femo-ral head by treatment with alendronate 显示文摘 | Peled E Bejar J Zinman C | 2009 | Arch Orthop Trauma Surg2009，129，2： | 1 |
| 11 | Laminar flow across a bank of low aspect ratio micro pin fins显示文摘 | Kosar A Mishra C Peles Y | 2005 | Journal of Fluids Engineering2005，127，3： | 1 |
| 12 | Bortezomib(velcade)when given pretransplant and once weekly as consolidation therapy following high dose chemotherapy (HDCT) leads to high rates of reactivation of varicella zoster virus (VZV)显示文摘 | Peles S Fisher NM Devine SM | 2005 | Blood2005，106，： | 1 |
| 13 | Enhancement of bone formation by bone morphogenetic protein-2 during alveolar distraction:an experimental study in sheep显示文摘 | Aizenbud D Peled M | 2004 | J Periodontol2004，75，11： | 1 |
| 14 | Dependence of human stem cell engraftment and repopulation of NOD/SCIDmice on CXCR4显示文摘 | Petit I Kollet O | 1999 | Science1999，283，5403： | 1 |
| 15 | Osseous Reconstruction Using a Membrane Barrier Following Marginal Mandibulectomy:An Animal Pilot Study显示文摘 | Peled M Machtei EE Rachmiel A | 2007 | J Periodontol2007，73，12： | 1 |
| 16 | Geometrical characteristics and efficiency of textile fabrics for reinforcing cement eomposites显示文摘 | PELED A BENTUR A | 2000 | Cement and Concrete Research2000，30，5： | 1 |
| 17 | Dependence of human stem cell engraftment and repopulation of NOD/NCID mice on CXCR4显示文摘 | Peled A Petit I Kollet O | 1999 | Science1999，283，： | 1 |
| 18 | Long-lasting sleep patterns of adult patients with mi-nor traumatic brain injury (mTBI) and non-mTBI subjects显示文摘 | Schreiber S Barkai G Gur-Hartman T Peles E Tov N DolbergO T | 2007 | Sleep Med2007，9，： | 1 |
| 19 | Laminar flow across a bank of low aspect ratio micro pin fins 显示文摘 | KOSAR A MISI-IRA C PELES Y | 2005 | Journal of Fluids Engineering-Transactions of the ASME2005，127，3： | 1 |
| 20 | Matrix metalloproteinases and the ontogeny of scarless repair: the other side of the wound healing balance显示文摘 | Peled ZM Phelps ED Updike DL | 2002 | Plast Reconstr Surg2002，110，3： | 1 |
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