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| 1 | Simultaneous X-ray Measurements in- situ of Tri-axial Stresses, Poisson's Ratio and the Stress Free Lattice Spacing, Strain显示文摘 | PEITER A | 1987 | 23(8): 103-1081987，23，8： | 1 |
| 2 | A secretory pathway-localized cation diffusion facilitator confers plant manganese tolerance 显示文摘 | PEITER E MONTANINI B GOBERT A | 2007 | PLANT BIOLOGY2007，104，20： | 1 |
| 3 | Syphilis management and treatment 显示文摘 | Peiter C | 1998 | Dermatol Clin1998，16，4： | 1 |
| 4 | The stone forum : Implementing a consensus building methodology to address impacts associated with small mining and quarry operations 显示文摘 | Peiter C Villas-Boas R C Shinya W | 2000 | Natural Resources Forum2000，24，： | 1 |
| 5 | Potassium in agriculture-status and perspectives显示文摘 | Z?rb C Senbayram M Peiter E | 2014 | Journal of Plant Physiology2014，171，： | 1 |
| 6 | Determination of the enzyme activity of activated sludge by methylene blue reduction 显示文摘 | | 1984 | Journal WPCF1984，56，1： | 1 |
| 7 | Potassium in agriculture – Status and perspectives显示文摘 | Christian Z?rb Mehmet Senbayram Edgar Peiter | 2014 | Journal of Plant Physiology2014，，9： | 1 |
| 8 | A secretory pathway-localized cation diffusion facilitator confers plant manganesetolerance显示文摘 | Peiter E Montanini B Gobert A | 2007 | Proc Natl Acad Sci USA2007，104，20： | 1 |
| 9 | Potassium inagriculture-status and perspectives显示文摘 | Z Orb C Senbayram M Peiter E | 2014 | Journal ofPlant Physiology2014，171，9： | 1 |
| 10 | Potassium in agriculture- Status and perspectives 显示文摘 | Christian Zorb Mehmet Senbayram Edgar Peiter | 2014 | Journal of Plant Physiology2014，171，： | 1 |
| 11 | Melatonin as a radioprotectire agent: a review显示文摘 | Vijayalaxmi Peiter R J Tan DX | 2004 | Int J Radiat Oncol Biol Phys2004，59，3： | 1 |
| 12 | Amelioration by L-Arginin of a dysfunction arginin/nitric oxide pathway in diabetic endothelium显示文摘 | PIEPER G M PEITER B A | 1995 | J Cardiovascular Pharmacol1995，25，3： | 1 |
| 13 | COVID-19 liver and gastroenterology findings:An in silico analysis of SARS-CoV-2 interactions with liver molecules显示文摘BACKGROUND Coronavirus disease 19(COVID-19)has not only been shown to affect the respiratory system,but has also demonstrated variable clinical presentations including gastrointestinal tract disorders.In addition,abnormalities in liver enzymes have been reported indicating hepatic injury.It is known that severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)might infect cells via the viral receptor angiotensin-converting enzyme 2(ACE2)which is expressed in several organs including the liver.The viral Spike glycoprotein binds to ACE2 and must be cleaved by Furin and Type 2 Serine Protease to enter the cells.After that,the Akt/mTOR signaling pathway is activated and several COVID-19 changes are triggered.AIM To analyze liver and gastrointestinal symptoms and cell signaling pathways triggered by SARS-CoV-2 infection due to virus-liver interactions in silico.METHODS In this in silico study,the three-dimensional structures of the Akt,mTORC1 and Furin(receptors)were selected from the Protein Data Bank(PDB)and the structures of inhibitors(ligands)MK-2206,CC-223 and Naphthofluorescein were selected from PubChem and ZINC databases.Ligand files were downloaded as 2D structures and converted to optimized 3D structures using ViewerLite 4.2 software.Marvin Sketch®software was used to calculate prediction of the protonated form of inhibitors in a physiological environment(pH 7.4).AutoDock Tools(ADT)software was used to calculate and delimit the Grid box used in the molecular docking of each structure selected in the PDB.In addition,protonated ligands were prepared for molecular docking using ADT software.Molecular docking was performed using ADT software tools connected to Vina software.Analysis of the amino acid residues involved in ligand interactions,as well as ligand twists,the atoms involved in interactions,bond type and strength of interactions were performed using PyMol^(■)and Discovery Studio^(■)(BIOVIA)software.RESULTS Molecular docking analysis showed that the mTORC1/CC-223 complex had affinity energy between the receptor and ligand of-7.7 kcal/moL with interactions ranging from 2.7 to 4.99Å.There were four significant chemical bonds which involved two of five polypeptide chains that formed the FKBP12–Rapamycin-Binding(FRB)domain.The strongest was a hydrogen bond,the only polar interaction,and Van der Waals interactions shown to be present in 12 residues of mTORC1’s FRB domain.With regard to the Akt/MK-2206 complex there were three Van der Waals interactions and 12 chemical bonds in which seven residues of Akt were involved with all five rings of the MK-2206 structure.In this way,both ASP 388 and GLN 391 bind to the same MK-2206 ring,the smaller one.However,LYS 386 had four chemical bonds with the inhibitor,one with each structure ring,while LYS 387 binds two distinct rings.One of the MK-2206 inhibitor's rings which binds to LYS 387 also binds simultaneously to ILE 367 and LEU 385 residues,and the fifth ring of the structure was involved in a bond with the ALA 382 residue.The hydrogen bonds were the shortest bonds in the complex(2.61 and 3.08Å)and all interactions had an affinity energy of-8.8 kcal/moL.The affinity energy in the Furin/Naphhofluorescein complex was-9.8 kcal/moL and involved six interactions ranging from 2.57 to 4.98Å.Among them,two were polar and the others were non-polar,in addition to twelve more Van der Waals interactions.Two distinct hydrogen bonds were formed between Furin and its inhibitor involving GLN 388 and ALA 532 residues.ALA 532 also binds to two distinct rings of Naphthofluorescein,while TRP 531 residue has two simultaneous bonds with the inhibitor.CONCLUSION Liver infection and signaling pathways altered by SARS-CoV-2 can be modulated by inhibitors that demonstrate significant interaction affinity with human proteins,which could prevent the development of infection and symptoms. | Gabrielle Caroline Peiter Cristiano de Bem Torquato de Souza Lucca Miketen de Oliveira Luis Gustavo Pagliarin Valentina Nunes Fontoura dos Anjos Filipe Antônio França da Silva Fabrício Freire de Melo Kádima Nayara Teixeira | 2022 | World Journal of Hepatology2022，14，6： | 1 |
| 14 | A secretory pathwaylocalized cation diffusion facilitator confers plant manganese tolerance 显示文摘 | Peiter E Montanini B Gobert A | 2007 | PNAS2007，104，20： | 1 |
| 15 | Study of Hydrogen Diffusion in Boron/Germanium Codoped Optical Fiber显示文摘 | Swart Peiter L Chtcherbakov Anatoli A | 2002 | Journal of LightwaveTechnology2002，20，11： | 1 |
| 16 | Chemotherapy in 998 unselected childhood acute lymphoblastic leukemia patients, results and conclusions of the multicenter trial, ALL-BFM86 显示文摘 | Peiter A Seherappe M Ludwig WD | 1994 | Blood1994，84，9： | 1 |
| 17 | Potassium in agriculture- Status and perspectives 显示文摘 | ZORB C SENBAYRAM M PEITER E | 2014 | Journal of Plant Physiology2014，171，9： | 1 |
| 18 | Characterizing diagnoses and systems显示文摘 | De Kleer J Mackworth A K Peiter R | 1992 | Artificial Intelligence1992，56，23： | 1 |
| 19 | Protecting military convoys in Iraq:an examination of battle injuries sustained by a mechanized battalion during Operation Iraqi Freedom II显示文摘 | Gondusky JS Peiter MP | 2005 | Mil Med2005，170，6： | 1 |
| 20 | Temporal pattern of humoral immune response in mild cases of COVID-19显示文摘BACKGROUND Understanding the humoral response pattern of coronavirus disease 2019(COVID-19)is one of the essential factors to better characterize the immune memory of patients,which allows understanding the temporality of reinfection,provides answers about the efficacy and durability of protection against severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),and consequently helps in global public health and vaccination strategy.Among the patients who became infected with SARS-CoV-2,the majority who did not progress to death were those who developed the mild COVID-19,so understanding the pattern and temporality of the antibody response of these patients is certainly relevant.AIM To investigate the temporal pattern of humoral response of specific immunoglobulin G(IgG)in mild cases of COVID-19.METHODS Blood samples from 191 COVID-19 real-time reverse transcriptase-polymerase chain reaction(RT-qPCR)-positive volunteers from the municipality of Toledo/Paraná/Brazil,underwent two distinct serological tests,enzyme-linked immunosorbent assay,and detection of anti-nucleocapsid IgG.Blood samples and clinicoepidemiological data of the volunteers were collected between November 2020 and February 2021.All assays were performed in duplicate and the manufacturers'recommendations were strictly followed.The data were statistically analyzed using multiple logistic regression;the variables were selected by applying the P<0.05 criterion.RESULTS Serological tests to detect specific IgG were performed on serum samples from volunteers who were diagnosed as being positive by RT-qPCR for COVID-19 or had disease onset in the time interval from less than 1 mo to 7 mo.The time periods when the highest number of participants with detectable IgG was observed were 1,2 and 3 mo.It was observed that 9.42%of participants no longer had detectable IgG antibodies 1 mo only after being infected with SARS-CoV-2 and 1.57%were also IgG negative at less than 1 mo.At 5 mo,3.14%of volunteers were IgG negative,and at 6 or 7 mo,1 volunteer(0.52%)had no detectable IgG.During the period between diagnosis by RT-qPCR/symptoms onset and the date of collection for the study,no statistical significance was observed for any association analyzed.Moreover,considering the age category between 31 and 59 years as the exposed group,the P value was 0.11 for the category 31 to 59 years and 0.32 for the category 60 years or older,showing that in both age categories there was no association between the pair of variables analyzed.Regarding chronic disease,the exposure group consisted of the participants without any comorbidity,so the P value of 0.07 for the category of those with at least one chronic disease showed no association between the two variables.CONCLUSION A temporal pattern of IgG response was not observed,but it is suggested that immunological memory is weak and there is no association between IgG production and age or chronic disease in mild COVID-19. | Isadora Maria Pilati Campos Milena Marques Gabrielle Caroline Peiter Ana Paula Carneiro Brandalize Mauricio Bedim dos Santos Fabrício Freire de Melo Kádima Nayara Teixeira | 2023 | World Journal of Biological Chemistry2023，14，2： | 0 |
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