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| 1 | Hypoxia increases adipogenesis and affects adipocytokine production in orbital fibroblasts-a possible explanation of the link between smoking and Graves' ophthalmopathy显示文摘AIM:To assess the effects of hypoxia on human orbital fibroblasts(OF)on adipogenesis and adipocytokine production.METHODS:Human OF were derived from tissues obtained from patients with Graves'ophthalmopathy(GO)and from patients without known thyroid diseases undergoing blepharoplasty.The OF were cultured separately under normoxic and hypoxic conditions.Comparisons of adipocytokine concentrations using multiplex ELISA and lipid accumulation in the cells using Oil Red O staining were subsequently performed.RESULTS:There was increased adipogenesis in OF from GO subject when exposed to hypoxic culture conditions.This was not observed in OF from normal controls.Hypoxia led to an increase in leptin and a decrease in MCP-1 secretion in OF cultures.CONCLUSION:Hypoxia induces adipogenesis in OF and may represent a mechanism by which smoking contributes to deterioration of GO.We also found novel changes to leptin and MCP-1 production in OF cultures exposed to hypoxia suggesting important roles of these cytokines in the disease process. | Chiaw Ling Chng Oi Fah Lai Charmaine Sze-Min Chew Yu Pei Peh Stephanie Man-Chung Fook-Chong Lay Leng Seah Daphne Hsu-Chin Khoo | 2014 | International Journal of Ophthalmology(English edition)2014，7，3： | 10 |
| 2 | Enhancement of norfloxacin solubility via inclusion complexation with β-cyclodextrin and its derivative hydroxypropyl-β-cyclodextrin显示文摘The objectives of the study were to investigate the effects of β-cyclodextrin(βCD) and hydroxypropyl-β-cyclodextrin(HPβCD) on the solubility and dissolution rate of norfloxacin prepared using three different methods, at drug to cyclodextrin weight ratios of 1:1, 1:2, 1:4 and 1:8. All the methods increased the solubility and dissolution rate of norfloxacin via inclusion complexation with βCD and HPβCD. Norfloxacin was converted from crystalline to amorphous form through inclusion complexation. Solvent evaporation method was the most effective method in terms of norfloxacin solubilisation, while inclusion complex of HPβCD has higher solubility than βCD complex when prepared using the same procedure. | Gabriel Onn Kit Loh Yvonne Tze Fung Tan Kok-Khiang Peh | 2016 | Asian Journal of Pharmaceutical Sciences2016，11，4： | 4 |
| 3 | Cobalt-containing covalent organic frameworks for visible light-driven hydrogen evolution显示文摘Covalent organic frameworks(COFs) have recently emerged as a new class of photocatalysts.However,integrated design is crucial to maximizing the performance of COF-incorporating photocatalytic systems.Herein,we compare two strategies of installing earth-abundant metal-based catalytic centers into the matrice of a 2 D COF named NUS-55.Compared to NUS-55(Co)prepared from the post-synthetic metalation of coordination sites within the COF,the molecular co-catalyst impregnated NUS-55/[Co(bpy)3]Cl2 achieves a seven-fold improvement in visible light-driven H2 evolution rate to 2,480 μmol g^-1h^-1,with an apparent quantum efficiency(AQE) of 1.55% at 450 nm.Our results show that the rational design of molecular anchoring sites in COFs for the introduction of catalytic metal sites can be a viable strategy for the development of highly efficient photocatalysts with enhanced stability and photocatalytic activities. | Jian Wang Jian Zhang Shing Bo Peh Guoliang Liu Tanay Kundu Jinqiao Dong Yunpan Ying Yuhong Qian Dan Zhao | 2020 | Science China Chemistry2020，63，2： | 2 |
| 4 | Arteriovenous shunting in hepatocellular carcinoma: Its prevalence and clinical significance显示文摘 | H. Ngan W.C.G. Peh | 1997 | Clinical Radiology1997，，1： | 2 |
| 5 | Nasal and nasaltype nature killer(NK)/T cell lymphoma inmunophenotype and Epstein Barry virus(EBV) association显示文摘 | Peh SC Quen QW | 2003 | Med J Malaysia2003，58，2： | 1 |
| 6 | Pereutaneous vertebroplasty for severe ostcopprotiee vertebral body compression fractures显示文摘 | Gilula L Peeh D | 2002 | Radiology2002，223，1： | 1 |
| 7 | Simple high-performance liquid chromatographic method for the determination of metformin in human plasma显示文摘 | Kah Hay Yuen Kok Khiang Peh | 1998 | J Chromato B1998，710，12： | 1 |
| 8 | Function of the SIRT1 protein deacetylase in cancer显示文摘 | Stunkel W Peh B K Tan Y C | 2007 | Biotechnol J2007，2，11： | 1 |
| 9 | Pereutaneous vertebral aug- mentation : vertebroplasty, kyphoplasty and skyphoplasty 显示文摘 | Peh WC Munk PL Rashid F | 2008 | Radi- ol Clin North Am2008，46，3： | 1 |
| 10 | Artemisinins:pharmacological actions beyond anti-malarial显示文摘 | Ho WE Peh HY Chan TK | 2014 | Pharmacol Ther2014，142，1： | 1 |
| 11 | Elevated peritoneal fluid luteinizing hormone and prolactin concentrations in infertile women with endometriosis显示文摘 | Peh KL Loganath R | 1990 | Int J Gynecol Obstet1990，5，4： | 1 |
| 12 | Acute vertebral body compression fractures:discrimination between benign and malignant causes using apparent diffusion coefficients显示文摘 | Peh WC Tsui EY | 2002 | Br J Radiol2002，75，891： | 1 |
| 13 | P53 protein expression in transitional cell carcinoma of the bladder-experience of the university of Malaya Medical Centre显示文摘 | Ong TA Peh SC Goh KS | 2003 | Asian J Surg2003，26，1： | 1 |
| 14 | Percutaneous vertebroplasty:indications,contraindications and technique显示文摘 | Peh W C Gilula L A | 2003 | Br J Radiol2003，76，901： | 1 |
| 15 | Case 84: desmoid tumor of the abdominal wall显示文摘 | Teo HE Peh WC Shek TW | 2005 | Radiology2005，236，1： | 1 |
| 16 | Percutaneous vertebroplasty:treatment of painful vertebral compression fractures with intraosseous vacuum phenomena显示文摘 | Peh WCG Gelbart MS Gilula LA | 2003 | AJR2003，180，： | 1 |
| 17 | Percutaneous vertebroplasty: indications, contraindications, and technique显示文摘 | Peh WC Gilula LA | 2003 | Br J Radiol2003，，901： | 1 |
| 18 | Arteriovenous shunting in hepatocellular carcinoma :its prevalence and clinical signifinance显示文摘 | Peh WC | 1997 | Clin Radiol1997，52，1： | 1 |
| 19 | Percutaneous vertebral augmentation:vertebroplasty,kyphoplasty and skyphoplasty显示文摘 | Peh WC Munk PL Rashid F | 2008 | Radiol Clin North Am2008，46，3： | 1 |
| 20 | Application of similarity factor in development of controlled-release dihiazem tablet 显示文摘 | Peh KK Wong CF | 2000 | Drug Dev and Ind Pharm2000，26，7： | 1 |
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