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| 1 | NCB-02 (standardized Curcumin preparation) protects dinitrochlorobenzene-induced colitis through down-regulation of NFκ-B and iNOS显示文摘AIM: To evaluate the efficacy and mechanism of action of NCB-02, a standardized Curcumin preparation, against 2, 4-dinitrochlorobenzene (DNCB)-induced ulcerative colitis in rats. METHODS: Ulcerative colitis was induced in male rats by sensitizing with topical application of DNCB in acetone for 14 d and intra-colonol challenge with DNCB on day 15. A separate group of animals with vehicle treatment in similar fashion served as control group. Colitis rats were divided into different groups and treated with NCB-02 at doses of 25, 50 and 100 mg/kg b.wt p.o. for 10 d. Sulfasalazine at a dose of 100 mg/kg b.wt for 10 d served as a reference group. On day 10 after respective assigned treatment, all the animals were euthanized and the length of the colon, weight of entire colon and distal 8 cm of the colon were recorded. The distal part of the colon was immediately observed under a stereomicroscope and the degree of damage was scored. Further distal 8 cm of the colon was subject to the determination of colonic myeloperoxidase (MPO), lipid peroxidation (LPO) and alkaline phosphatase (ALP) activities. A small piece of the sample from distal colon of each animal was fixed in 10% neutral buffered formalin and embedded in paraffin wax and sectioned for immunohistochemical examination of NFκ-B and iNOS expression. RESULTS: NCB-02 showed a dose dependent protection against DNCB-induced alteration in colon length and weight. NCB-02 treatment also showed a dose dependent protection against the elevated levels of MPO, LPO and ALP, induced by DNCB. NCB-02 demonstrated a significant effect at a dose of 100 mg/kg b.wt., which was almost equipotent to 100 mg/kg b.wt. of sulfasalazine. Treatment with sulfasalazine and curcuminat a dose of 100 mg/kg b.wt. inhibited the DNCB-induced overexpression of NFκ-B and iNOS in the colon. CONCLUSION: Curcumin treatment ameliorates colonic damage in DNCB-induced colitic rats, an effect associated with an improvement in intestinal oxidative stress and downregulation of colonic NFκ-B and iNOS expression. | MV Venkataranganna Md Rafiq S Gopumadhavan Ghouse Peer UV Babu SK Mitra | 2007 | World Journal of Gastroenterology2007，13，7： | 12 |
| 2 | 个体网络借贷(P2P)监管立法例及解读显示文摘央行会同其他部委发布的《关于促进互联网金融健康发展的指导意见》明确了'网络借贷业务由银监会负责监管'。十八届五中全会《关于制定国民经济和社会发展第十三个五年规划》要求'规范发展互联网金融'。银监会直面网络借贷(P2P)存在的诸多问题,如何有效地规范发展网络借贷(P2P)活动已经成为亟待解决的问题。规范发展网络借贷(P2P)应以保障投资者合法权益为主轴,以防范其风险发生与传染作为监管措施确立的出发点,以实现普惠金融作为目标,进而促进网络借贷(P2P)的健康持续发展与不断创新。个体网络借贷(P2P)监管立法在体现适度宽松监管政策,坚持适度监管、有效监管、创新监管等原则基础上满足上述要求,从而保障监管立法成为规范监管的善法。 | The Experts’ Suggestion of Rules of Peer to Peer Lending (P2P)Supervision Legislation bythe Expert’s Panel of Central University of Finance and Economics | 2016 | 财经法学2016，，1： | 6 |
| 3 | Second generation biofuels:high efficiency microalgae for biodiesel production显示文摘 | Peer M S Skye R T Evan S | 2008 | Bioenergy Research2008，1，： | 1 |
| 4 | PAL2NAL: Robust con version of protein sequence alignments into the corre sponding codon alignments 显示文摘 | Mikita S David T Peer B | 2006 | Nucleic Acids Res2006，34，： | 1 |
| 5 | Direct digital radi- ography versus storage phosphor radiography in the detection of wrist fraction 显示文摘 | Peer S Neitzel U Giacomuzzi SM | 2002 | Clin Radiol2002，57，： | 1 |
| 6 | Nanocarriers as an emer?ging platform for cancer therapy显示文摘 | Peer D Karp J M Hong S | 2007 | Nat Nanotechn2007，2，12： | 1 |
| 7 | Examination of Postoperative Peripheral Nerve Lesions with High -resolution Sonography显示文摘 | Peer S Bodner G Meirer R | 2001 | AJR2001，177，： | 1 |
| 8 | Sonographic feature of horseshoe kidney:review of 34 patients显示文摘 | Strauss S Dushnitsky T Peer A | 2000 | J Uhras Med2000，19，1： | 1 |
| 9 | Flavonoids and auxin transport: modulators or regulators显示文摘 | PEER W A MURPHY A S | 2007 | Trends Plant Sci2007，12，12： | 1 |
| 10 | Grand challenges in modulating the immune response with RNAi nanomedicines显示文摘 | Goldsmith M Mizrahy S Peer D | 2011 | Nanomedicine2011，6，10： | 1 |
| 11 | Functional analysis of LOXL2 in pancreatic carcinoma显示文摘 | Felix R Peer J Hans - Detlev S | 2010 | Int J Colorectal Dis2010，25，3： | 1 |
| 12 | Context relevance assessment and exploitation in mobile recommender systems显示文摘 | Baltrunas L Ludwig B Peer S Ricci F | 2012 | Personal and Ubiquitous Computing2012，16，5： | 1 |
| 13 | Nutritional compositions con-talning beta casomorphins显示文摘 | Carine J Minter S Peer F | 1989 | Uk-patent Application1989，，2： | 1 |
| 14 | Integration of genome data and protein structures:prediction of protein folds,protein interactions and 'molecular phenotypes' of single nucleotide polymorphisms显示文摘 | SHAMIL S PEER B | 2001 | Current Opinion in Structural Biology2001，11，1： | 1 |
| 15 | Intermediate fre- quencies of egg ejection by Northern Mockingbirds (Mimus polyglottos) smpatric with two cowbird species显示文摘 | Peer B D Ellison K S Sealy S G | 2002 | The Auk2002，119，3： | 1 |
| 16 | PDX:PBX complexes are required for normal proliferation of pancreatic cells during development显示文摘 | DUTTA S GANNON M PEERS B | 2001 | Proc Natl Acad Sci USA2001，98，3： | 1 |
| 17 | PDX:PDX complexes are required for normal proliferation of pancreatic cells during development显示文摘 | DUCTAL S GANMON M PEERS B | 2001 | Proc Natl Acad Sci USA2001，98，3： | 1 |
| 18 | Database on the structure of small ribosomal subunit RNA显示文摘 | VAN DE PEER Y NICOLAI S DE WACHTER R | 1996 | Nucleic Acids Res1996，24，： | 1 |
| 19 | We finding in tibial adamantinoma: a case report 显示文摘 | Jadmaier W peer S krejzi T | 1998 | Acta Raaiol1998，39，： | 1 |
| 20 | Endothelial cell protein C receptor plays an important role in protein C activation in vivo显示文摘 | Taylor F B Jr Peer G T Leekhart M S | 2001 | Blood2001，97，6： | 1 |
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