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| 1 | Suppression of m6A reader Ythdf2 promotes hematopoietic stem cell expansion显示文摘 | Zhenrui Li Pengxu Qian Wanqing Shao Hailing Shi Xi C. He Madelaine Gogol Zulin Yu Yongfu Wang Meijie Qi Yunfei Zhu John M. Perry Kai Zhang Fang Tao Kun Zhou Deqing Hu Yingli Han Chongbei Zhao Richard Alexander Hanzhang Xu Shiyuan Chen Allison Peak Kathyrn Hall Michael Peterson Anoja Perera Jeffrey S. Haug Tari Parmely Hua Li Bin Shen Julia Zeitlinger Chuan He Linheng Li | 2018 | Cell Research2018，28，9： | 18 |
| 2 | Analysis of a Peaked Carbon Emission Pathway in China Toward Carbon Neutrality显示文摘1.Introduction Climate change is currently the most significant untraditional challenge to human development.Most countries have reached an agreement to reduce their carbon emissions to address this challenge[1,2].As the world’s second largest economy,largest energy consumer,and largest carbon dioxide emitter,China plays an important and constructive role in global climate governance[3].Thus far,carbon dioxide emissions(referred to herein as“carbon emissions”)have peaked in over 50 countries,including the United States,whose carbon emissions peaked in 2007. | Project Team on the Strategy and Pathway for Peaked Carbon Emissions and Carbon Neutrality | 2021 | Engineering2021，7，12： | 9 |
| 3 | Pharmacokinetics and pharmacodynamics of lignocaine: A review显示文摘Lignocaine is an essential drug on World Health Organisation essential drug list, considered efficacious, safe and cost-effective for any health-care system. Despite its ubiquitous use in medicine and surgery, there are few detailed reviews of its pharmacokinetics and pharmacodynamics. Being an amide-type local anesthetic and Class 1b antiarrhythmic, lignocaine is most frequently used clinically for its anesthetic and antiarrhythmic benefits. However, lignocaine has important antinociceptive, immuno-modulating, and antiinflammatory properties. Information pertaining to the pharmacokinetics and pharmacodynamics of lignocaine was examined by performing a literature search of Pub Med, Embase and MEDLINE(via Ovid), pharmacology textbooks and online sources. We present a focused synopsis of lignocaine's pharmacological composition, indications for use and mechanisms of action, focusing on its anti-inflammatory, immuno-modulating and analgesia effects. In addition we review the dosing regimes and infusion kinetics of lignocaine in the clinical setting. Finally, we review the evidence for ligocaine's modulation of the inflammatory response during major surgery and its specific effects on cancer recurrence. These indirect effects of local anesthetics in tumor development may stem from the reduction of neuroendocrine responses to the stress response elicited by major surgery and tissue damage, enhanced preservation of immune-competence, in addition to opioid-sparing effects of modulating tumor growth. | Laurence Weinberg Benjamin Peake Chong Tan Mehrdad Nikfarjam | 2015 | World Journal of Anesthesiology2015，4，2： | 9 |
| 4 | Stem cell therapy for the treatment of Leydig cell dysfunction in primary hypogonadism显示文摘The production of testosterone occurs within the Leydig cells of the testes. When production fails at this level from either congenital, acquired, or systemic disorders,the result is primary hypogonadism. While numerous testosterone formulations have been developed, none are yet fully capable of replicating the physiological patterns of testosterone secretion. Multiple stem cell therapies to restore androgenic function of the testes are under investigation. Leydig cells derived from bone marrow, adipose tissue, umbilical cord, and the testes have shown promise for future therapy for primary hypogonadism. In particular, the discovery and utilization of a group of progenitor stem cells within the testes, known as stem Leydig cells(SLCs), has led not only to a better understanding of testicular development, but of treatment as well. When combining this with an understanding of the mechanisms that lead to Leydig cell dysfunction, researchers and physicians will be able to develop stem cell therapies that target the specific step in the steroidogenic process that is deficient. The current preclinical studies highlight the complex nature of regenerating this steroidogenic process and the problems remain unresolved. In summary, there appears to be two current directions for stem cell therapy in male primary hypogonadism. The first method involves differentiating adult Leydig cells from stem cells of various origins from bone marrow, adipose, or embryonic sources. The second method involves isolating, identifying, and transplanting stem Leydig cells into testicular tissue. Theoretically, in-vivo re-activation of SLCs in men with primary hypogonadism due to age would be another alternative method to treat hypogonadism while eliminating the need for transplantation. | Taylor C Peak Nora M Haney William Wang Kenneth J DeLay Wayne J Hellstrom | 2016 | World Journal of Stem Cells2016，8，10： | 5 |
| 5 | Neutrophil activation, antioxidant supplements and exerciseinduced oxidative stress 显示文摘 | Peake J Suzuki K | 2004 | EJcerc Immunol Rev2004，10，2： | 1 |
| 6 | Photochemically induced changes in dissolved organic matter identified by ultrahigh resolution Fourier transform ion cyclotron resonance mass spectrometry 显示文摘 | Gonsior M Peake B M Cooper W T | 2009 | Environmental Science Technology2009，43，3： | 1 |
| 7 | Cardiac parasympa- thetic reactivation following exercise: Implications for training prescription显示文摘 | STANLY J PEAKE J M BUCHHEIT M | 2013 | Sports Med2013，43，： | 1 |
| 8 | Snake activity affects seasonal variation in nest predation risk for birds显示文摘 | Jinelle H. Sperry Rebecca G. Peak David A. Cimprich Patrick J. Weatherhead | 2008 | Journal of Avian Biology2008，，： | 1 |
| 9 | Dissolved organic carbon and organic acids in coastal New Zealand rainwater显示文摘 | Kieber J R Peake B Willey D J | 2002 | Atmos Environ2002，36，21： | 1 |
| 10 | 显示文摘 | IHM Hyejae Peak Kyungsoo | 1999 | Bull Korean Chem Soc1999，20，6： | 1 |
| 11 | On the nature of the 1994 East Asian summer drought显示文摘 | PEAK C K | 1997 | Journal of Climate1997，，10： | 1 |
| 12 | The carcinogenicity of environmental tobacco smoke显示文摘 | Witschi HP Espiritu I Peake JL | 1997 | Carcinogenesis1997，18，3： | 1 |
| 13 | A review of scattering from surfaces with different roughness scales显示文摘 | Barrick D E Peake W H | 1968 | Radio Science1968，3，1： | 1 |
| 14 | Organoehlorine pesticides in a dated sedimentcore from Mapua,Waimea Inlet,New Zealand显示文摘 | Hendy E Peake B M | 1996 | Mar Pollute Bull1996，32，： | 1 |
| 15 | Individuality in comcrake Crex crex vocalizations显示文摘 | Peake T M McGregor P K Smith K W | 1998 | Ibis1998，140，： | 1 |
| 16 | Retention rate of levetiracetam in children with intractable epilepsy at 1 year显示文摘 | Peake D Mordekar S Gosalakkal J | 2007 | Seizure2007，16，2： | 1 |
| 17 | Rotor-stator interaction noise in swirling flow:stator sweep and lean effects显示文摘 | Cooper A J Peake N | | 0，，05： | 1 |
| 18 | Semiquantitative,bar code version of immunochromatographic assay system for human serum albumin as model analyte显示文摘 | Cho J H Peak S H | 2001 | Biotechnol Bioeng2001，75，6： | 1 |
| 19 | Measuring IS system service quality with SERVQUAL: Users' perceptions of relative importance of the five SERVPERF dimensions 显示文摘 | LANDRUM H PRYBUTOK V ZHANG X PEAK D | 2009 | Informing Science: the International Joumal of an Emerging Transdiscipline2009，12，： | 1 |
| 20 | In vitro and in vivo activities of LB10827,a new oral cephalosporin,against respiratory pathogens显示文摘 | Peak K S Kim M Y LEE C S | 2000 | Antimicrob Agents Chemother2000，44，12： | 1 |
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