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| 1 | Optimal length of triple therapy for H pylori eradication in a population with high prevalence of infection in Chile显示文摘AIM:To compare the efficacy of 7-d versus 14-d triple therapy for the treatment of H pylori infection in Chile,with a prevalence of 73% in general population. METHODS:H pylori-infected patients diagnosed by rapid urease test,with non-ulcer dyspepsia or peptic ulcer disease were randomized to receive omeprazole 20 mg bid,amoxicillin 1 g bid,and clarithromycin 500 mg bid for 7 (OAC7) or 14 (OAC14) d. Primary outcome was eradication rate 6 wk after the treatment. Subgroup analysis was carried out considering the eradication rate among patients with or without peptic ulcer disease and eradication rate among smokers or non-smokers. RESULTS:One hundred and thirty-one patients were randomized to OAC7 (n = 69) or OAC14 (n = 62). The overall eradication rate (intention-to-treat) was 78.3% in OAC7 and 85.5% in OAC14 groups,without a significant difference (P =0.37). No significant difference in the eradication rate was found among the patients with peptic ulcer disease (n = 31) between the OAC7 group (85.7%) and OAC14 group (87.5%). However,smokers had an obviously lower eradication rate compared to non-smokers,particularly in the OAC7 group (57.1% in smokers vs 83.6% in non-smokers; P = 0.06). Adverse effects rate were similar between both groups. CONCLUSION:Short-term efficacy of triple therapy with OAC for 7 d is comparable to 14 d in this high-prevalence population. Longer follow-up,and studies focused to some subgroups of patients (smokers and non-ulcerpatients) are necessary to support widespread use of 7-d instead of 10-14-d triple therapy in a developing country like Chile. | Arnoldo Riquelme Alejandro Soza Cesar Pedreros Andrea Bustamante Felipe Valenzuela Francisco Otarola Eduardo Abbott Marco Arellano Brenda Medina Alejandro Pattillo Douglas Greig Marco Arrese Antonio Rollan | 2007 | World Journal of Gastroenterology2007，13，21： | 3 |
| 2 | TrkB activation by brain-derived neurotrophic factor inhibits the Gprotein-gated inward rectifier Kir3 by tyrosine phosphorylation of the channel显示文摘 | Rogalski SL Appleyard SM Pattillo A | 2000 | J Biol Chem2000，275，25： | 1 |
| 3 | Measurement of plasma hydrogen sulfide in vivo and in vitro 显示文摘 | Shen X Pattillo CB Pardue S | 2011 | Free Radio Biol Med2011，50，9： | 1 |
| 4 | Targeting of the antivascular drug combretastatin to irradiated tumors results in tumor growth delay 显示文摘 | Nallamothu R Pattillo CB Moore BM | 2005 | Pharm Res2005，22，7： | 1 |
| 5 | Measurement of plas- ma hydrogen sulfide in vivo and in vitro显示文摘 | Shen XG Pattillo CB Pardue S | 2011 | Free Radie Biol Med2011，50，9： | 1 |
| 6 | Fetal pulse oximetry:Cormlatinn between oxygen desaturatinn,duration,and frequency and neonatal outcomes显示文摘 | David M Gorenberg MD Carol Pattillo RNC | 2003 | Am J Obstet Gynecol2003，189，1： | 1 |
| 7 | Chronic sodium nitrite therapy augments ischemia-induced angiogenesis and arteriogenesis 显示文摘 | Kumar D Branch BG Pattillo CB | 2008 | Proc Natl Acad Sci U S A2008，105，21： | 1 |
| 8 | Application of vacuum-insulated tubing to mitigate annular pressure buildup显示文摘 | Azzola J H Tselepidakis D P Pattillo P D | 2007 | SPE Drilling & Completion2007，22，1： | 1 |
| 9 | Predicting currency crises:The indicators approach and an alternative显示文摘 | Berg A Pattillo C | | 0，，18： | 1 |
| 10 | Predicting Currency Crises: The Indicators Approach and An Ahemative显示文摘 | Berg A Pattillo C | 1999 | Journal of International Money and Finance1999，18，4： | 1 |
| 11 | Predicting currency crises : The indicators approach and an alternative显示文摘 | Andrew Berg Catherine Pattillo | 1999 | Journal of International Money and Finance1999，，18： | 1 |
| 12 | Are Currency Crises Predictable? A Test显示文摘 | BERG A PATTILLO C | 1999 | IMF Staff Paper1999，46，2： | 1 |
| 13 | Neurobehavioral effects of low-level lead exposure in human neonates显示文摘 | Emory E Pattillo R Archibold E | 1999 | Am J Obstet Gynecol1999，181，： | 1 |
| 14 | Effect of nonuniform loading on conventional casing collapse resistance显示文摘 | Pattillo P D Last N C Asbill W T | 2004 | SPE Drilling and Completion2004，19，3： | 1 |
| 15 | Helical budding of a tube in an inclined wellbore显示文摘 | Pattillo P D | 2000 | International Journal of Non-Linear Mechanies2000，35，5： | 1 |
| 16 | TSG101expression in gynecological tumors:relationship to cydin D1,cydin E,p53 and p16 protein显示文摘 | Bennett NA Pattillo RA Lin RS | 2001 | Cell/Viol Biol(Noisy-le-grand)2001，47，7： | 1 |
| 17 | TrkB activation by brain-derived-neurotrophic-factor inhibits the Gprotein-gated-inward-rectifier Kir3 by tyrosine phosphorylation of the channel显示文摘 | Rogalski SL Appleyard SM Pattillo A | 2000 | J Biol Chem2000，275，25： | 1 |
| 18 | Evaluation,impact, and management of casing deformation caused bytectonic forces in the Andean Foothills, Colombia 显示文摘 | Last NC Mujica S Pattillo PD Kelso GT | 2006 | SPEDrilling Completion2006，21，2： | 1 |
| 19 | Investment, uncertainty and irreversibility in Ghana显示文摘 | Pattillo C | 1998 | IMF Staff Paper1998，45，3： | 1 |
| 20 | PTEN/MMAC1 mutations correlate inversely with an altered p53 tumor suppressor gene in gynecologic tumors显示文摘 | Soyoola E O Pattillo R A | 2003 | Am J Obstet Gynecol2003，188，4： | 1 |
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