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| 1 | m-AAA proteases, mitochondrial calcium homeostasis and neurodegeneration显示文摘线粒体的功能无所不在地取决于表示并且在内部膜的进化保存 m-AAA 朊酶。这些 ATP 依赖的 peptidases 形式 hexameric 建筑群相应子单元积聚了。AFG3L2 子单元 homo-oligomeric isoenzymes 集合进或与 SPG7 (paraplegin ) 子单元进 hetero-oligomeric 解朊的建筑群。在 AFG3L2 的变化与 Purkinje 房间的损失描绘的主导的 spinocerebellar 混乱(SCA28 ) 被联系,而在 SPG7 的变化与 cortico 针的道的马达神经原引起世袭痉挛截瘫(HSP7 ) 的一种后退的形式主要被影响。多种的功能被分到 m-AAA 朊酶,它在线粒体充当质量控制和规章的酶。m-AAA 朊酶的损失影响 mitochondrial 蛋白质合成和呼吸并且在线粒体的 axonal 运输导致 mitochondrial 破碎和缺乏。而且 m-AAA 朊酶调整 mitochondrial 钙 uniporter (MCU ) 的集会复杂。在 AFG3L2 缺乏的线粒体的 MCU 子单元 EMRE 的损害降级为导致钙的房间死亡导致 deregulated MCU 建筑群,增加的 mitochondrial 钙举起和神经原的增加的危险的形成。进 Purkinje 房间的 cytosol 的钙流入的减小在一个 AFG3L2 缺乏的老鼠模型救混乱。在这评论,我们为 neurodegeneration 讨论在 m-AAA 朊酶和 mitochondrial 钙动态平衡和它的关联之间的关系并且描述在 Purkinje 房间明确地缺乏 MCU 的一个新奇老鼠模型。我们为在线粒体集成他们的多种的功能解释联系 neurodegenerative 混乱的致病的 m-AAA 朊酶上的一个新奇看法的结果誓言。 | Maria Patron, Hans-Georg Sprenger, Thomas Langer Maria Patron, Hans-Georg Sprenger, Thomas Langer | 2018 | Cell Research2018，28，3： | 3 |
| 2 | Minimally invasive surgical treatment of intrahepatic cholangiocarcinoma:A systematic review显示文摘BACKGROUND Intrahepatic cholangiocarcinoma(ICC)is the second most common primary liver cancer and is characterized by an aggressive behavior and a dismal prognosis.Radical surgical resection represents the only potentially curative treatment.Despite the increasing acceptance of laparoscopic liver resection for surgical treatment of malignant liver diseases,its use for ICC is not commonly performed.In fact,to achieve surgical free margins a major resection and/or vascular and/or biliary reconstructions is often needed,as well as an associated lymph node dissection.AIM To review and summarize the current evidences on the minimally invasive resection of ICC.METHODS A systematic review of the literature based on the criteria predetermined by the investigators was performed from the 1st of January 2009 up to the 1st of January2021 in 4 databases(PubMed,Scopus,Google Scholar,and Cochrane databases).All retrospective and prospective studies reporting on the comparative outcomes of open vs minimally invasive treatment of ICC were included.An evaluation of manuscripts quality was achieved using Methodological Index for Non-Randomized Studies criteria and Newcastle-Ottawa Scale.RESULTS After a systematic search 9 studies fulfilled the inclusion criteria.Among the all 3012 included patients,2450 were operated by an open approach and 562 by a minimally invasive(laparoscopic)approach.Baseline characteristics,tumor characteristics,surgical outcomes and oncological outcomes were collected and analyzed,highlighting values with a statistical significant difference between patients treated with open or laparoscopic approach.Shorter hospital stay and lower intraoperative blood losses were reported by some Authors in minimally invasive surgery,on the contrary,in the open group there was a higher number of lymphadenectomies and a higher percentage of major hepatectomies.CONCLUSION Minimally invasive resection of ICC has some short-term benefits and it is safe and feasible only in selected centers with a high experience in laparoscopic approach for liver surgery.Minimally invasive surgery,actually,was considered mainly in patients with a tumor with a diameter<5 cm,without invasion of main biliary duct or main vessel and no vascular or biliary reconstructions were planned.Further studies are needed to elucidate its impact on long term oncologic outcomes. | Renato Patrone Francesco Izzo Raffaele Palaia Vincenza Granata Guglielmo Nasti Alessandro Ottaiano Gilda Pasta Andrea Belli | 2021 | World Journal of Gastrointestinal Oncology2021，13，12： | 3 |
| 3 | Micromorphological investigation on the leaves of the rock samphire (Crithmum maritimum L.): Occurrence of hesperidin and diosmin crystals显示文摘 | L. Cornara C. D'Arrigo F. Pioli B. Borghesi C. Bottino E. Patrone M. G. Mariotti | 2009 | Plant Biosystems - An International Journal Dealing with all Aspects of Plant Biology2009，，2： | 2 |
| 4 | The Impact of Delay in Software-Defined Integrated Terrestrial-Satellite Networks显示文摘Satellite communication networks have been evolving from standalone networks with ad-hoc infrastructures to possibly interconnected portions of a wider Future Internet architecture. Experts belonging to the fifth-generation(5 G) standardization committees are considering satellites as a technology to integrate in the 5 G environment. Software Defined Networking(SDN) is one of the paradigms of the next generation of mobile and fixed communications. It can be employed to perform different control functionalities, such as routing, because it allows traffic flow identification based on different parameters and traffic flow management in a centralized way. A centralized set of controllers makes the decisions and sends the corresponding forwarding rules for each traffic flow to the involved intermediate nodes that practically forward data up to the destination. The time to perform this process in integrated terrestrial-satellite networks could be not negligible due to satellite link delays. The aim of this paper is to introduce an SDN-based terrestrial satellite network architecture and to estimate the mean time to deliver the data of a new traffic flow from the source to the destination including the time required to transfer SDN control actions. The practical effect is to identify the maximum performance than can be expected. | Luca Boero Mario Marchese Fabio Patrone | 2018 | China Communications2018，15，8： | 2 |
| 5 | The effect of osteogenic protein-1 on the healing of segmental bone defects treated with autograft or allograft bone显示文摘 | Salkeld SL Patron LP Barrack RL | 2001 | J Bone Joinr Surg(Am)2001，83，6： | 2 |
| 6 | Actively bleeding Dieulafoy's lesion of the small bowel identified by capsule endoscopy and treated by push enteroscopy显示文摘Dieulafoy 的损害是周期性的官方补给的流血的一个不平常的原因。这份报告描述活跃地为 Dieulafoy 诊断被囊内视镜检查法在做的小肠的损害放血的一个案例,与推肠寄生物的使用由治疗列在后面。案例说明那囊内视镜检查法,肠寄生物在有小肠疾病的病人是高度补足的。 | Giovanni D De Palma Francesco Patrone Maria Rega Immacolata Simeoli Stefania Masone Giovanni Persico | 2006 | World Journal of Gastroenterology2006，12，24： | 2 |
| 7 | Lysostaphin treatment of experimental methicillin-resistant Staphylococcus aureus aortic valve endocarditis显示文摘 | Climo M W Patron R L Goldstein B P | 1998 | Antimicrobial Agents and Chemotherapy1998，42，6： | 1 |
| 8 | Repair of articular cartilage defects with osteogenic protein-1(BMP-7) in dogs显示文摘 | Cook SD Patron LP Salkeld SL | | 0，，3： | 1 |
| 9 | Genes expressed during the IFN- gamma induced maturation of pre-B-cells 显示文摘 | Patrone L Damore MA Lee MB | 2002 | Mol Immunol2002，38，8： | 1 |
| 10 | Lysostaphin treatment of experimental aortic valve endocarditis caused by a Staphylococcus aureus isolate with reduced susceptibility to vancomycin显示文摘 | Patron R L Climo M W Goldstein B P | 1999 | Antimicrobial Agents and Chemotherapy1999，43，7： | 1 |
| 11 | Leptomeningeal metrastrases:MR evaluation显示文摘 | Yousem DM Patrone PM Grossman R | 1990 | J Comput Assist Tomogr1990，14，： | 1 |
| 12 | Nosocomial infections in children: prevalence survey in 21 public hospitals in Mexico显示文摘 | Avila-- Figueroa C Cashat -- Cruz M Aranda -- Patron E et al | 1999 | Salud Publica Mex1999，411，： | 1 |
| 13 | Activation of A431 human carcinoma cell motility by extracellular high-mobility group box 1 protein and epidermal growth factor stimuli 显示文摘 | Sparatore B Patrone M Passalacqua M | 2005 | Biochem J2005，389，1： | 1 |
| 14 | The effect of osteogenicprotein-1 on the healing of segmental bone defects treated with autograft or allograft bone 显示文摘 | Salkeld SL Patron LP Barrack RL | 2001 | J Bone Joint Surg(Am)2001，83，6： | 1 |
| 15 | Evolutionary ancestry and novel functions of the mammalian glucose transporter (GLUT) familyI显示文摘 | Wilson-O'Brien AL Patron N Rogers S | | 0，，： | 1 |
| 16 | Preexisting depressive symptoms are associated with long-term cognitive decline in patients after cardiac surgery显示文摘 | Patron E Messerotti BS Zanatta P | 2013 | Gen Hosp Psychiatry2013，35，5： | 1 |
| 17 | Watching fat digestion显示文摘 | PATRON J S CARREY M C | 1979 | Science1979，204，4389： | 1 |
| 18 | Lysostaphin treatment of experimental Methicillin-Resistant Staphylococcus aureus aoritiz valve endvcarditis 显示文摘 | Climo MW Patron RL Beth PL | 1998 | Antimicrob Agents Chemother1998，42，6： | 1 |
| 19 | Lysostaphin treatment of experimental methicinin-resistant Staphylococcus aureus aortic valve endocarditis显示文摘 | Climo M W Patron R L Goldstein B P | 1998 | Antimicrob Agents Chemother1998，42，6： | 1 |
| 20 | Polymorphous low-grade adenocarcinoma of the oral cavity:a report of 14 cases显示文摘 | Colmenero C M Patron M Burgueno M | 1992 | J Oral Maxillofac Surg1992，50，6： | 1 |
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