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3篇 您的检索式：作者名="Patrick Michl"

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		题名	作者	年代	出处	被引量
	1	Liver-specific therapies for metastases of neuroendocrine pancreatic tumors显示文摘The presence or development of liver metastases in patients with neuroendocrine pancreatic tumors is the most important prognostic factor.Liver resection,transplantation and many different therapeutic approaches are discussed in this special review.	Volker Fendrich Patrick Michl Nils Habbe Detlef Klaus Bartsch	2010	World Journal of Hepatology2010，2，10：	6
	2	Nicotine Promotes Initiation and Progression of KRAS-Induced Pancreatic Cancer via Gata6- Dependent Dedifferentiation of Acinar Cells in Mice显示文摘	Patrick C. Hermann Patricia Sancho Marta Ca?amero Paola Martinelli Francesc Madriles Patrick Michl Thomas Gress Ricardo de Pascual Luis Gandia Carmen Guerra Mariano Barbacid Martin Wagner Catarina R. Vieira Alexandra Aicher Francisco X. Real Bruno Sainz C	2014	Gastroenterology2014，，：	1
	3	Pancreatic cancer–Outlook: targeted therapy显示文摘Pancreatic cancer is a devastating disease characterized by almost identical incidence and mortality rates. Since this tumour is mostly diagnosed in an advanced stage there is usually no option for a curative surgical resection. In addition, pancreatic cancers known to be resistant to conventional treatment modalities such as chemotherapy and radiotherapy. Therefore, novel strategies for targeting these tumors are urgently needed. The increasing knowledge on the underlying pathogenetic mechanisms has led to the identification of surface receptor molecules that initiate intracellular signalling cascades upon ligand binding, thus leading to tumor progression. Targeting these receptors or their secreted ligands is therefore an attractive new approach for cancer therapy. The epidermal growth factor receptor (EGFR) and the vascular endothelial growth factor receptor (VEGFR) are transmembrane tyrosine kinase receptors which can be targeted by various compounds such as antibodies or small molecule inhibitors. In addition, various molecules targeting proteins secreted by pancreatic cancers such as matrix metalloproteinases (MMP’s) or intracellular oncogenic signalling components such as the farnesyltransferase have been proposed as potential new approaches for targeted cancer therapy. The use of these agents alone or in combination with conventional therapeutic regimens is currently being evaluated and shows first promising results for pancreatic cancer therapy.	Patrick Michl Thomas M. Gress	2007	The Chinese-German Journal of Clinical Oncology2007，6，2：	0

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