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| 1 | Long-term outcome of pancreatic function following oncological surgery in children:Institutional experience and review of the literature显示文摘BACKGROUND Pancreatic neoplasms are uncommon in children and in most cases they are benign or have low malignant potential.Pancreatoblastoma and solid pseudopapillary tumor are the most frequent types in early and late childhood,respectively.Complete resection,although burdened by severe complications,is the only curative treatment for these diseases.Pancreatic surgery may result in impaired exocrine and endocrine pancreatic function.However,limited data are available on the long-term pediatric pancreatic function following surgical resection.AIM To investigate endocrine and exocrine pancreatic function and growth after oncological pancreatic surgery in a pediatric series.METHODS A retrospective analysis of all pediatric patients who underwent surgery for pancreatic neoplasm in our Institution from January 31,2002 to the present was performed.Endocrine and exocrine insufficiency,auxological and fat-soluble vitamin status(A,D,E and clotting tests)were assessed at diagnosis and at every follow-up visit.Exocrine insufficiency was defined as steatorrhea with fecal elastase-1<200μg/g stool,while endocrine insufficiency was identified as onset of Diabetes or Impaired Glucose Tolerance.Growth was evaluated based on body mass index(BMI)z-score trend.RESULTS Sixteen patients(12 girls and 4 boys,mean age 10.7±5.3 years),were included.Nine patients(56%)had a neoplasm in the pancreatic head,4 in the body/tail,2 in the tail and 1 in the body.Histological findings were as follows:Solid pseudopapillary tumor in 10 patients(62.5%),insulinoma in 2 patients,neuroendocrine tumor in 2 patients and acinar cell carcinoma in 2 patients.The most frequent surgery was pancreaticoduodenectomy(50%).Exocrine failure occurred in 4 patients(25%)and endocrine failure in 2 patients(12.5%).Exocrine insufficiency occurred early(within 6 mo after surgery)and endocrine insufficiency later(8 and 10 years after surgery).Mean BMI z-score was 0.36±1.1 at diagnosis and 0.27±0.95 at the last assessment.Vitamin D was insufficient(<30 ng/mL)in 8 of the 16 patients during the follow-up period.Vitamins A,E and clotting test were into the normal ranges in all patients.CONCLUSION Careful and long-term monitoring should follow any pancreatic surgery,to recognize and promptly treat exocrine and endocrine pancreatic insufficiency,which can occur after surgery. | Giulia Bolasco Teresa Capriati Chiara Grimaldi Lidia Monti Maria Debora De Pasquale Ippolita Patrizia Patera Marco Spada Giuseppe Maggiore Antonella Diamanti | 2021 | World Journal of Clinical Cases2021，9，25： | 2 |
| 2 | A spectral element method for fluid dynamics:laminar flow in a channel expansion显示文摘 | PATERA A T | 1984 | J Comput Phys1984，54，： | 1 |
| 3 | General method for calculating satellite collision probability显示文摘 | Patera R P | 2001 | Journal of Guidance Control and Dynamics2001，24，4： | 1 |
| 4 | A spectral element method for fluid dynamics: Laminar flow in a channel expansion显示文摘 | Patera A T | 1984 | Journal of Computational Physics1984，54，3： | 1 |
| 5 | A spectral element method for fluid dynamics:laminar flow in a channel expansion显示文摘 | Patera A T | 1994 | J Comput Acoust 2(4)1994，，： | 1 |
| 6 | Freeze-thaw stability in flour confectionery显示文摘 | Pateras I.M.C | | 0，，： | 1 |
| 7 | The implications of positive psychological capital on employee absenteeism 显示文摘 | Avey J B Patera J L West B J | 2006 | Journal of Leadership & Organizational Studies2006，13，： | 1 |
| 8 | p57kip2 : 'Kip' ing the cell under control 显示文摘 | Pateras I S Apostolopoulou K Niforou K | 2009 | Mol Cancer Res2009，7，12： | 1 |
| 9 | Space vehicle maneuver method to lower collision risk to an acceptable level显示文摘 | Patera R P Peterson G E | 2003 | Journal of Guidance Control and Dynamics2003，26，2： | 1 |
| 10 | A spectral element method for fluid dynamics: Laminar flow in a channel expansion显示文摘 | PATERA A T | 1984 | Journal of Computational Physics1984，54，3： | 1 |
| 11 | General method for calculating satellite collision probability 显示文摘 | Patera R P | 2001 | Journal of Guidance Control and Dynamics2001，24，4： | 1 |
| 12 | Contribution of bridging ligament rupture to energy absorption during fracture of metal ceramic laminates显示文摘 | Pateras S K Howard S J Clyne T W | 1997 | Key Engineering Materials1997，，： | 1 |
| 13 | Spectral element methods for the incompressible Navier-Stokes equations显示文摘 | MADAY Y PATERA A T | 1989 | American Society of Mechanical Engineers1989，，： | 1 |
| 14 | The implica- tions of positivepsychological capital on employee absenteeism显示文摘 | AVEY JB PATERA JL WEST BJ | 2006 | Journal of Leadership and Organi- zational Studies2006，13，： | 1 |
| 15 | Satellite collision probability for non-linear relative motion显示文摘 | Patera R P | 2003 | Journal of Guidance Control and Dynamics2003，26，5： | 1 |
| 16 | Immunohistochemical evaluation of human epidermal growth factor receptor 2 and estrogen and progesterone receptors in invasive breast cancer in women显示文摘 | Badowska-Kozakiewicz AM Sobol M Patera J | 2013 | Arch Med Sci2013，209，3： | 1 |
| 17 | Experimental analysis of a web-based training intervention to develop positive psychological capital显示文摘 | Luthans F Avey JB Patera JL | 2008 | Academy of Management Learning & Education2008，7，2： | 1 |
| 18 | A spectral element method for fluid dynamics: laminar flow in a channel expansion 显示文摘 | PATERA A T | 1984 | Journal of Computational Physics1984，54，： | 1 |
| 19 | General method for calculating satellite collision probability显示文摘 | Patera Russell P | 2001 | Journal of Guidance Control and Dynamics2001，24，4： | 1 |
| 20 | General Method for Calculating Satellite Collision Probability 显示文摘 | Russell P Patera | 2001 | Journal of Guidance Control And Dynamics2001，24，4： | 1 |
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