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| 1 | Aggressive behaviour of solid-pseudopapillary tumor of the pancreas in adults:A case report and review of the literature显示文摘Solid-pseudopapillary tumor (SPT) is a rare neoplasm of the pancreas that usually occurs in young females. It is generally considered a low-grade malignant tumor that can remain asymptomatic for several years. The occurrence of infiltrating varieties of SPT is around 10%-15%. Between 1986 and 2006, 282 cystic tumors of the pancreas were observed. Among them a SPT was diagnosed in 8 patients (2.8%) with only one infiltrating variety. This was diagnosed in a 49-year-old female 13 years after the sonographic evidence of a small pancreatic cystic lesion interpreted as a pseudocyst. The tumor invaded a long segment of the portal- mesenteric vein confluence, and was removed with a total pancreatectomy, resection of the portal vein and reconstruction with the internal jugular vein. Histological examination confirmed the R-0 resection of the primary SPT, although a vascular invasion was demonstrated. The postoperative course was uneventful, but 32 mo after surgery the patient experienced diffuse liver metastases. Chemotherapy with different drugs was started. The patient is alive and symptom-free, with stable disease, 75 mo after surgery. Twenty-five patients with invasion of the portal vein and/or of mesenteric vessels were retrieved from the literature, 16 recent patients with tumor relapse after potentially curative resection were also retrieved. The best treatment remains a radical resection whenever possible, even in locally advanced or metastatic disease. The role of chemotherapy, and/or radiotherapy, is still to be defined. | Cosimo Sperti Mattia Berselli Claudio Pasquali Davide Pastorelli Sergio Pedrazzoli | 2008 | World Journal of Gastroenterology2008，14，6： | 44 |
| 2 | Differential diagnosis in inflammatory bowel disease colitis:State of the art and future perspectives显示文摘Distinction between Crohn's disease of the colonrectum and ulcerative colitis or inflammatory bowel disease(IBD) type unclassified can be of pivotal importance for a tailored clinical management,as each entity often involves specific therapeutic strategies and prognosis.Nonetheless,no gold standard is available and the uncertainty of diagnosis may frequently lead to misclassification or repeated examinations.Hence,we have performed a literature search to address the problem of differential diagnosis in IBD colitis,revised current and emerging diagnostic tools and refined disease classification strategies.Nowadays,the differential diagnosis is an untangled issue,and the proper diagnosis cannot be reached in up to 10% of patients presenting with IBD colitis.This topic is receiving emerging attention,as medical therapies,surgical approaches and leading prognostic outcomes require more and more disease-specific strategies in IBD patients.The optimization of standard diagnostic approaches based on clinical features,biomarkers,radiology,endoscopy and histopathology appears to provide only marginal benefits.Conversely,emerging diagnostic techniques in the field of gastrointestinal endoscopy,molecular pathology,genetics,epigenetics,metabolomics and proteomics have already shown promising results.Novel advanced endoscopic imaging techniques and biomarkers can shed new light for the differential diagnosis of IBD,better reflecting diverse disease behaviors based on specific pathogenic pathways. | Gian Eugenio Tontini Maurizio Vecchi Luca Pastorelli Markus F Neurath Helmut Neumann | 2015 | World Journal of Gastroenterology2015，21，1： | 13 |
| 3 | Neurological disorders and inflammatory bowel diseases显示文摘Extraintestinal manifestations occur in about one-third of patients living with inflammatory bowel disease(IBD) and may precede the onset of gastrointestinal symptoms by many years. Neurologic disorders associated with IBD are not frequent, being reported in 3% of patients, but they often represent an important cause of morbidity and a relevant diagnostic issue. In addition, the increasing use of immunosuppressant and biological therapies for IBD may also play a pivotal role in the development of neurological disorders of different type and pathogenesis. Hence, we provide a complete and profound review of the main features of neurological complications associated with IBD, with particular reference to those related to drugs and with a specific focus on their clinical presentation and possible pathophysiological mechanisms. | Giovanni Casella Gian Eugenio Tontini Gabrio Bassotti Luca Pastorelli Vincenzo Villanacci Luisa Spina Vittorio Baldini Maurizio Vecchi | 2014 | World Journal of Gastroenterology2014，20，27： | 7 |
| 4 | Proteomic insights on the metabolism in inflammatory bowel disease显示文摘Inflammatory bowel diseases(IBD)are chronic and relapsing inflammatory conditions of the gut that include Crohn's disease and ulcerative colitis.The pathogenesis of IBD is not completely unraveled,IBD are multi-factorial diseases with reported alterations in the gut microbiota,activation of different immune cell types,changes in the vascular endothelium,and alterations in the tight junctions’structure of the colonic epithelial cells.Proteomics represents a useful tool to enhance our biological understanding and to discover biomarkers in blood and intestinal specimens.It is expected to provide reproducible and quantitative data that can support clinical assessments and help clinicians in the diagnosis and treatment of IBD.Sometimes a differential diagnosis of Crohn's disease and ulcerative colitis and the prediction of treatment response can be deducted by finding meaningful biomarkers.Although some non-invasive biomarkers have been described,none can be considered as the“gold standard”for IBD diagnosis,disease activity and therapy outcome.For these reason new studies have proposed an“IBD signature”,which consists in a panel of biomarkers used to assess IBD.The above described approach characterizes“omics”and in this review we will focus on proteomics. | Laura Francesca Pisani Manuela Moriggi Cecilia Gelfi Maurizio Vecchi Luca Pastorelli | 2020 | World Journal of Gastroenterology2020，26，7： | 5 |
| 5 | Efficacy and tolerability of high and low-volume bowel preparation compared:A real-life single-blinded large-population study显示文摘BACKGROUND Low-volume preparations for colonoscopy have shown similar efficacy compared to high-volume ones in randomized controlled trials(RCT).However,most RCTs do not provide data about clinical outcomes including lesions detection rate.Moreover,real-life comparisons are lacking.AIM To compare efficacy(both in terms of adequate bowel preparation and detection of colorectal lesions)and tolerability of a high-volume(HV:4 L polyethylene glycol,PEG)and a low-volume(LV:2 L PEG plus bisacodyl)bowel preparation in a real-life setting.METHODS Consecutive outpatients referred for colonoscopy were prospectively enrolled between 1 December 2014 and 31 December 2016.Patients could choose either LV or HV preparation,with a day-before schedule for morning colonoscopies and a split-dose for afternoon procedures.Adequate bowel preparation according to Boston Bowel Preparation Scale(BBPS),clinical outcomes including polyp detection rate(PDR),adenoma detection rate(ADR),advanced adenoma detection rate(AADR),sessile/serrated lesion detection rate(SDR)and cancer detection rate and self-reported tolerability of HV and LV were blindly assessed.RESULTS Total 2040 patients were enrolled and 1815(mean age 60.6 years,50.2%men)finally included.LV was chosen by 52%of patients(50.8%of men,54.9%of women).Split-dose schedule was more common with HV(44.7%vs 38.2%,P=0.005).High-definition scopes were used in 33.4%of patients,without difference in the two groups(P=0.605).HV and LV preparations showed similar adequate bowel preparation rates(89.2%vs 86.6%,P=0.098),also considering the two different schedules(HV split-dose 93.8%vs LV split-dose 93.6%,P=1;HV daybefore 85.5%vs LV day-before 82.3%,P=0.182).Mean global BBPS score was higher for HV preparations(7.1±1.7 vs 6.8±1.6,P<0.001).After adjustment for sex,age and indications for colonoscopy,HV preparation resulted higher in PDR[Odds ratio(OR)1.32,95%CI:1.07-1.63,P=0.011]and ADR(OR 1.29,95%CI 1.02–1.63,P=0.038)and comparable to LV in AADR(OR 1.51,95%CI 0.97-2.35,P=0.069),SDR and cancer detection rate.The use of standard-definition colonoscopes was associated to lower PDR(adjusted OR 1.59,95%CI:1.22-2.08,P<0.001),ADR(adjusted OR 1.71,95%CI:1.26–2.30,P<0.001)and AADR(adjusted OR 1.97,95%CI:1.09-3.56,P=0.025)in patients receiving LV preparation.Mean Visual Analogue Scale tolerability scored equally(7,P=0.627)but a≥75%dose intake was more frequent with LV(94.6%vs 92.1%,P=0.003).CONCLUSION In a real-life setting,PEG-based low-volume preparation with bisacodyl showed similar efficacy and tolerability compared to standard HV preparation.However,with higher PDR and ADR,HV should still be considered as the reference standard for clinical trials and the preferred option in screening colonoscopy,especially when colonoscopy is performed with standard resolution imaging. | Vincenzo Occhipinti Paola Soriani Francesco Bagolini Valentina Milani Emanuele Rondonotti Maria Laura Annunziata Flaminia Cavallaro Sara Vavassori Maurizio Vecchi Luca Pastorelli Gian Eugenio Tontini | 2021 | World Journal of Gastrointestinal Endoscopy2021，13，12： | 4 |
| 6 | Direct torque control of induction machines using space vector modulation 显示文摘 | flABETLER T G PROFUMO F PASTORELLI M | 1992 | IEEE Transactions on Industry Applications1992，28，5： | 1 |
| 7 | Study of the migration of benzophenone from printed paperboard packages to cakes through different plastic films 显示文摘 | Pastorelli S Sanches-Silva A Cruz J M | 2008 | Eur Food Res Technol2008，227，： | 1 |
| 8 | Time-dependent effect of statins on platelet function in hypercholesterolaemia显示文摘 | Puccetti L Pasqui AL Pastorelli M | 2002 | Eur J Clin Invest2002，32，： | 1 |
| 9 | Direct Torque control of Induction motor drives using space vector modulation显示文摘 | HABETLER T G PROFUMNO F PASTORELLI M | 1992 | On Industry Application1992，28，5： | 1 |
| 10 | Performance of a pneumatic force controlling servosystem: influence of valves conductance 显示文摘 | SORLI M PASTORELLI S | 2000 | Robotics2000，30，3： | 1 |
| 11 | Platelet hyperactivity after statin treatment discontinuation 显示文摘 | Puccetti L Pasqui AL Pastorelli M | 2003 | Thromb Haemost2003，90，47： | 1 |
| 12 | Effect of atorvastatin on differ- ent fibrinolyis mechanisms in hypercholesterolemic subjects显示文摘 | Bruni F Pasqui AL Pastorelli M | 2004 | Int J Cardiol2004，95，23： | 1 |
| 13 | Advantages and limitations of duckweed -based wastewater treatment systems 显示文摘 | Bonomo L Pastorelli G Zambon N | 1997 | Water SciTechnol1997，35，： | 1 |
| 14 | Advanced gastric cancer(GC) and cancer of the gastro-oesophageal junction(GEJ):focus on targeted therapies显示文摘 | Cappetta A Lonardi S Pastorelli D | 2012 | Crit Rev Oncol Hematol2012，81，1： | 1 |
| 15 | Study of the migration of benzophenone from printed paperboard packages to cakes through different plastic films显示文摘 | Pastorelli S Sanches-Silva A Cruz J M | 2008 | European Food Research and Technology2008，227，6： | 1 |
| 16 | Individual Differences in the Study of Human Aggression显示文摘 | Caprara G V Barbaranelli C Pastorelli C & Perugini M | 1994 | Aggressive Behavior1994，20，： | 1 |
| 17 | Epithelial-derived IL-33 and its receptor ST2 are dysregulated in ulcerative colitis and in experimental Thl/Th2 driven enteritis显示文摘 | Pastorelli L Garg RR Hoang SB | 2010 | Pro Natl Acad Sci USA2010，107，17： | 1 |
| 18 | Associations between genetic polymorphisms in IL-33, IL1R1 and risk for inflammatory bowel disease显示文摘 | Latiano A Palmieri O Pastorelli L | 2013 | PLoS One2013，8，62： | 1 |
| 19 | Direct torque control of induction machines using space vector modulation 显示文摘 | Habetler TG Profumo F Pastorelli M Tolbert LM | 1992 | IEEE Trans Ind Appl (S0093-9994)1992，28，5： | 1 |
| 20 | Effect of dietary conjugated linoleic acid supplementation in sows on performance and immunoglobulin concentration in piglets显示文摘 | Corino C Pastorelli G Rosi F | 2009 | J Anim Sci2009，87，7： | 1 |
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