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	题名	作者	年代	出处	被引量
1	Evaluation of antiviral activities of Houttuynia cordata Thunb.extract,quercetin,quercetrin and cinanserin on murine coronavirus and dengue virus infection显示文摘Objective:To evaluate the in vitro activities of the ethyl acetate(EA) fraction of Houttuynia cordata(H.cordata) Thunb.(Saururaceae) and three of its constituent flavonoids(quercetin.quercitrin and rutin) against murine coronavirus and dengue virus(DENV).Methods:The antiviral activities of various concentrations of the EA fraction of H.cordata and flavonoids were assessed using virus neutralization tests against mouse hepatitis virus(MHV) and DENV type 2(DENV-2).Cinanserin hydrochloride was also tested against MHV.The EA fraction of H.cordata was tested for acute oral toxicity in C57BL/6 mice.Results:The EA fraction of H.cordata inhibited viral infectivity up to 6 d.Cinanserin hydrochloride was able to inhibit MHV for only 2 d.The 50%inhibitory concentrations(IC_(50)) of the EA fraction of H.cordata added before the viral adsorption stage were 0.98 μg/mL for MHV and 7.50 μg/mL for DENV-2with absence of cytotoxicity.The mice fed with the EA fraction up to 2 000 mg/kg did not induce any signs of acute toxicity,with normal histological features of major organs.Certain flavonoids exhibited comparatively weaker antiviral activity,notably quercetin which could inhibit both MHV and DENV-2.This was followed by quercitrin which could inhibit DENV-2but not MHV,whereas rutin did not exert any inhibitory effect on either virus.When quercetin was combined with quercitrin,enhancement of anti-DENV-2 activity and reduced cytotoxicity were observed.However,the synergistic efficacy of the flavonoid combination was still less than that of the EA fraction.Conclusions:The compounds in H.cordata contribute to the superior antiviral efficacy of the EA fraction which lacked cytotoxicity in vitro and acute toxicity in vim.H.cordata has much potential for the development of antiviral agents against coronavirus and dengue infections.	K.H.Chiow M.C.Phoon Thomas Putti Benny K.H.Tan Vincent T.Chow	2016	Asian Pacific Journal of Tropical Medicine2016，9，1：	38
2	Overexpression of cyclooxygenase-2 in nasopharyngeal carcinoma and association with epidermal growth factor receptor expression显示文摘	Soo R Putti T Tao Q	2005	Arch Otolaryngol Head Neck Surg2005，131，2：	1
3	Expression of myeloid markers laeks prognostic impaet in children treated for aeute lymphoblastic leukemia: Italian experience in AIEOP ALL88-91 studies显示文摘	Putti M C Rondelli R Caeito M G	1998	Blood1998，92，：	1
4	Magnetic Resonance in the Detection of Breast Cancers of Different Histological Types显示文摘	Mayrhofer RM Ng HP Putti TC	2013	Magn Reson Insights2013，6，：	1
5	Efficacy of dorsal longitudinal myelotomy in treating spinal spasticity:a review of 20 cases显示文摘	Putty TK Shapiro SA	1991	J Neurosurg1991，75，：	1
6	Epidermal growth factor receptor in undifferentiated carcinoma of the nasopharynx显示文摘	Leong JL Loh KS Putti TC		0，，1：	1
7	Expression of myeloid markers lacks prognostic impact in children treated for ALL: Italian experience in AIEOP-ALL 88 - 91 studies显示文摘	Putti MC Rondelli R Cocitd MG	1998	Blood1998，92，：	1
8	Cyclooxygenase 2 expression in nasopharyngeal carcinoma Ⅰ immunohistochemical findings and potential implications显示文摘	Tan K B Putti T C	2005	J Clin Pathol2005，58，5：	1
9	The significance of the Wnt pathway in the pathology of human cancers 显示文摘	Karim R Tse G Putti T	2004	Pathology2004，36，2：	1
10	Pediatric patients with essential thrombocythemia are mostly polyclonal and V617FJAK-2 negative显示文摘	Randi ML Putti MC Scapin M	2006	{H}Blood2006，，10：	1
11	Myelolipoma within a non-functional adrenal cortical adenoma 显示文摘	Ong K Tan KB Putti TC	2007	Singapore Med J2007，48，7：	1
12	Estrogen receptor-negative breast carcinomas: a review of morphology and immunophenotypical analysis显示文摘	PUTTI T C EL-REHIM D M A RAKHA E A	2004	Modem Pathology2004，18，1：	1
13	The significance of the Wnt pathway in the pathology of human cancers 显示文摘	Karim R Tse G Putti T	2004	Pathology2004，36，2：	1
14	Pediatric patients with essential thrombocythemia are mostly polyclonal and V617FJAK2 negative显示文摘	PUTTI MC SCAPIN M	2006	Blood2006，108，：	1
15	Neutron Irradiation of Mg11 B2:from the Enhancement to the Suppression of Super-conducting Properties显示文摘	Putti M Braccini V Ferdeghini C		0，，：	1
16	Pediatric patients with essential thrombocythemia are mostly polyclonal and V617FJAK2 negative显示文摘	Randi ML Putti MC Scapin M		0，，10：	1
17	Stromal CD10 expression in mammary fibroadenomas and phyllodes tumors显示文摘	Tse GM Tsang AK Putti TC		0，，：	1
18	Cyclooxygenase-2 expression in Warthin's turnout显示文摘	Loy AH Putti TC Tan LK	2005	J Laryngol Otol2005，119，7：	1
19	Stromal CD10 expression in mammary fibroadenomas and phyllodes tumors显示文摘	Tse G M K Tsang A K H Putti T C	2005	J Clin Pathol2005，58，：	1
20	Stromal CD10 expression in mammary fibroadenomas and phyllodes turnouts 显示文摘	Tse GMK Tsang AKH Putti TC	2005	JClinPatho2005，58，：	1

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