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| 1 | Controlling hypoxia-inducible factor-2α is critical for maintaining bone homeostasis in mice显示文摘Pathological bone loss is caused by an imbalance between bone formation and resorption.The bone microenvironments are hypoxic,and hypoxia-inducible factor (HIF) is known to play notable roles in bone remodeling.However,the relevant functions of HIF-2α are not well understood.Here,we have shown that HIF-2α deficiency in mice enhances bone mass through its effects on the differentiation of osteoblasts and osteoclasts.In vitro analyses revealed that HIF-2α inhibits osteoblast differentiation by targeting Twist2 and stimulates RANKL-induced osteoclastogenesis via regulation of Traf6.In addition,HIF-2α appears to contribute to the crosstalk between osteoblasts and osteoclasts by directly targeting RANKL in osteoprogenitor cells.Experiments performed with osteoblast- and osteoclast-specific conditional knockout mice supported a role of HIF-2α in this crosstalk.HIF-2α deficiency alleviated ovariectomy-induced bone loss in mice,and specific inhibition of HIF-2α with ZINC04179524 significantly blocked RANKLmediated osteoclastogenesis.Collectively,our results suggest that HIF-2α functions as a catabolic regulator in bone remodeling,which is critical for the maintenance of bone homeostasis. | Sun Young Lee Ka Hyon Park Hyung-Gu Yu Eunbyul Kook Won-Hyun Song Gyuseok Lee Jeong-Tae Koh Hong-In Shin Je-Yong Choi Yun Hyun Huh Je-Hwang Ryu | 2019 | Bone Research2019，7，2： | 5 |
| 2 | Mitochondria-targeting self-assembled nanoparticles derived from triphenylphosphonium-conjugated cyanostilbene enable site-specific imaging and anticancer drug delivery显示文摘为指向的同时的肿瘤的 Subcellular 细胞器特定的 nanoparticles,成像,和药交货具有对癌症治疗的庞大的兴趣。此处,我们报导一根选择指向线粒体的探针 1,它被与 cyanostilbene 和长烷基链一半合并 triphenyl 磷化氢综合。探查 1 被发现经由导致聚集的排放(AIE ) 显示荧光。低分子重量的基于 cyanostilbene 的探查有或没有 anticancer 药, 1 与 ca 形成了狭窄的同类的 nanorod。有 ca 的长度或 nanoparticles 的 110 nm。在水的媒介的 20 nm 直径。自我装配的 cyanostilbene nanoparticles (N1 ) 有选择地在癌症房间的线粒体积累了并且射出荧光。N1 也能交付 anticancer 药, doxorubicin (纪录影片) ,到有高效率的线粒体。更重要地, N1 在正常房间上为癌症房间展出了高度选择的 cytotoxicity。到生物系统的这自我装配的 nanoparticle 的大潜在的应用程序源于它在线粒体聚集的能力。这聚集在癌症房间在 mitochondrial 膜潜力在细胞内部的反应的氧种类并且到减少的产生导致了重要增加。而且,在老鼠的肿瘤织物举起实验建议自我装配的 N1 有能力使内在化并且有效地交付 anticancer 药进肿瘤纸巾。而且, N1 和包含 N1 的 doxorubicin (N1 纪录影片) 有效地在 vivo 在一个异种皮移植模型压制了肿瘤生长。一起拿,我们的调查结果显示 N1 的应用程序为潜在的指导图象的治疗以及一个地点特定的交货系统作为指向探查,药交货平台,和化学疗法的代理人的 mitochondrial 提供唯一的策略给癌症房间。 | Ka Young Kim Hanyong Jin Jaehyeon Park Sung Ho Jung Ji Ha Lee Hyesong Park Sung Kuk Kim Jeehyeon Bae Jong Hwa Jung | 2018 | Nano Research2018，11，2： | 4 |
| 3 | Reduction of ethyl benzoylacetate and selective protection of 2- (3-hydroxy-1- phenylpropyl) -4-methylphenol: A new and facile synthesis of tolterodine 显示文摘 | De Castro KA Ko J Park D | 2007 | Org Process Res Dev2007，11，5： | 1 |
| 4 | Stress radiographs after ankle frac- ture: the effect of ankle position and deltoid ligament status on medial clear space measurements 显示文摘 | Park SS Kubiak EN Egol KA | 2006 | J Orthop Trauma2006，20，1： | 1 |
| 5 | Stereoselective metabolism of lansoprazole by human liver cytochrome p450 enzymes显示文摘 | Kim KA kim MJ park JY | 2003 | Drug Metab Dispos2003，31，10： | 1 |
| 6 | Effect of ABCB1(MDR1)haplotypes derived from G2677T/C3435T on the pharma-cokinetics of amlodipine in healthy subjects显示文摘 | Kim KA Park PW Park JY | 2007 | Br J Clin Pharmacol2007，63，1： | 1 |
| 7 | Adipose-derived stemcells and their secrtory fnstors as a promising therapy for skin aging 显示文摘 | Park BS Jang KA Suag JH | 2008 | Dermatol Surg2008，34，10： | 1 |
| 8 | Effect of CYP3A5*3 genotype on the pharmacokinetics and antiplatelet effect of clopidogrel in healthy subjects显示文摘 | Kim KA Park PW Park JY | 2008 | Eur J Clin Pharmacol2008，64，6： | 1 |
| 9 | Adipose-derived stem ceils and their secretory factors as a promising therapy for skin aging显示文摘 | Park BS Jang KA Sung JH | 2008 | Dermatol Surg2008，34，10： | 1 |
| 10 | Adipose-derived stem cells and their secretory factors as a promising therapy for skin aging显示文摘 | Park BS Jang KA Sung JH | 2008 | Dermatol Surg2008，34，10： | 1 |
| 11 | Inhibition of cytochrome P450 activities by oleanolic acid and ursolic acid in human liver microsomes显示文摘 | Kim KA Lee JS Park HJ | | 0，，22： | 1 |
| 12 | Prospective surveillance for invasive fungal infections in hematopoietic stem cell transplant recipients,2001-2006:overview of the Transplant-Associated Infection Surveillance Network(TRANSNET)Database显示文摘 | Kontoyiannis DP Marr KA Park BJ | 2010 | Clin Infect Dis2010，50，8： | 1 |
| 13 | Hysteroscopic endometrial ablation as a treatment for abnormal uterine bleeding inpatients with renal transplants 显示文摘 | Jeong KA Park KH Chung D J | 2004 | J Am Assoc Gynecol Laparosc2004，11，2： | 1 |
| 14 | Am- yloid beta peptide induces cyto-chrome C release from isolated mitochondria 显示文摘 | Kim HS Lee JH Lee JP Kim EM Chang KA Park CH | 2002 | Neuroreport2002，13，15： | 1 |
| 15 | Temporal chan- ges in cerebral antioxidant enzyme activities after ische- mia and reperfusion in a rat focal brain ischemia model: effect of dietary fish oil 显示文摘 | Choi-Kwon S Park KA Lee HJ | 2004 | Brain Res Dev Brain Res2004，152，1： | 1 |
| 16 | Estimation of the current global burden of eryptococcal meningitis among persons living with HIV/AIDS显示文摘 | Park B J Wannemuehler KA Marston B J | 2009 | Aids2009，23，52： | 1 |
| 17 | Effect of metronidazole on the pharmacokinetics of fexofenadine, a P-glycoprotein substrate, in healthy male volunteers 显示文摘 | Kim KA Park JY | 2010 | Eur J ClinPharm2010，66，7： | 1 |
| 18 | Effect of CYP3A5-k 3 genotype on the pharmacokinetics and pharmacodynamics of alprazolam in healthy subjects显示文摘 | Park J Y Kim KA Park PW | 2006 | Clin Pharmacol Ther2006，79，6： | 1 |
| 19 | t(5;12)(q13;p13) in acule mye- loid leukemia vdth preceding granulocytie sarcoma 显示文摘 | Park TS Song J Lee KA | 2007 | Cancer Genet Cytogenet2007，177，2： | 1 |
| 20 | Effect of CYP3A5 * 3 genotype on the pharmacokinetics and pharmacodynamics of in amlodipine in healthy Korean subjects 显示文摘 | Kim KA Park PW Lee OJ | 2006 | Clin Pharmacol Ther2006，80，6： | 1 |
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