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| 1 | Laparoscopic approach to Meckel's diverticulum显示文摘AIM: To retrospective review the laparoscopic management of Meckel Diverticulum(MD) in two Italian Pediatric Surgery Centers.METHODS: Between January 2002 and December 2012, 19 trans-umbilical laparoscopic-assisted(TULA) procedures were performed for suspected MD. The children were hospitalized for gastrointestinal bleeding and/or recurrent abdominal pain. Median age at diagnosis was 5.4 years(range 6 mo-15 years). The study included 15 boys and 4 girls. All patients underwent clinical examination, routine laboratory tests, abdominal ultrasound and technetium-99m pertechnetate scan, and patients with bleeding underwent gastrointestinal endoscopy. The abdominal exploration was performed with a 10 mm operative laparoscope. Pneumoperitoneum was establishedbased on the body weight. Systematic overview of the peritoneal cavity allowed the ileum to be grasped with an atraumatic instrument. The complete exploration and surgical treatment of MD were performed extracorporeally, after intestinal exteriorization through the umbilicus. All patients' demographics, main clinical features, diagnostic investigations, operative time, histopathology reports, conversion rate, hospital stay and complications were registered and analyzed.RESULTS: MD was identified in 17 patients, while 1 had an ileal duplication and 1 a jejunal hemangioma. Fifteen patients had painless intestinal bleeding, while 4 had recurrent abdominal pain and exhibited cyst like structures in an ultrasound study. Eleven patients had a positive technetium-99m pertechnetate scan. In the patients with bleeding, gastrointestinal endoscopy did not name the source of hemorrhage. All patients were subjected to a TULA surgical procedure. An intestinal resection/anastomosis was performed in 14 patients, while 4 had a wedge resection of the diverticulum and 1 underwent stapling diverticulectomy. All surgical procedures were performed without conversion to open laparotomy. Mean operative time was 75 min(range 40-115 min). No major surgical complications were recorded. The median hospital stay was 5-7 d(range 4-13 d). All patients are asymptomatic at a median follow up of 4, 5 years(range 10 mo-10 years).CONCLUSION: Trans-umbilical laparoscopic-assisted Meckel's diverticulectomy is safe and effective in the treatment of MD, with excellent results. | Alfonso Papparella Fabiano Nino Carmine Noviello Antonio Marte Pio Parmeggiani Ascanio Martino Giovanni Cobellis | 2014 | World Journal of Gastroenterology2014，20，25： | 7 |
| 2 | CYP1A2 genotype modifies the association between coffee intake and the risk of hypertension显示文摘 | Paolo Palatini Giulio Ceolotto Fabio Ragazzo Francesca Dorigatti Francesca Saladini Italia Papparella Lucio Mos Giuseppe Zanata Massimo Santonastaso | 2009 | Journal of Hypertension2009，，8： | 1 |
| 3 | Interplay between miR -155, ATI R A1166C polymorphism, and AT1R expression in young un-treated hypertensives显示文摘 | Ceolotto G Papparella I Bortoluzzi A | 2011 | Am J Hypertens2011，24，2： | 1 |
| 4 | Downregula- tion of the longevity-associated protein sirtuin I in insulin resist- ance and metabolic syndrome:potential biochemical mechanisms 显示文摘 | De Kreutzenberg S V Ceolotto G Papparella I | 2010 | Diabetes2010，9，4： | 1 |
| 5 | Results and complications of laparoscopic surgery for pediatric varicocele显示文摘 | C. Esposito G. Monguzzi M.A. Gonzalez-Sabin R. Rubino L. Montinaro A. Papparella G. Esposito A. Settimi L. Mastroianni M. Zamparelli R. Sacco G. Amici R. Damiano N. Innaro | 2001 | Journal of Pediatric Surgery2001，，5： | 1 |
| 6 | Laparo-scopic management of nonpalpable testes a multicenter study of the i-talian society of video surgery in infancy显示文摘 | PAPPARELLA A PARMEGGIAN IP COBELLIS G | 2005 | J Pediatr Surg2005，40，4： | 1 |
| 7 | Uppergastrointestinal involvement of Crohn's disease: a prospectivestudy on the role of upper endoscopy in the diagnostic work-up显示文摘 | Annunziata ML Caviglia R Papparella LG | 2012 | Dig Dis Sci2012，57，6： | 1 |
| 8 | Upper Gastrointestinal Involvement of Crohn’s Disease: A Prospective Study on the Role of Upper Endoscopy in the Diagnostic Work-Up显示文摘 | Maria Annunziata Renato Caviglia Luigi Papparella Michele Cicala | 2012 | Digestive Diseases and Sciences2012，，6： | 1 |
| 9 | Down regulation of the longevity-associated protein sirtuin 1 in insulin resistance and metabolic syndrome:potential biochemical mechanisms显示文摘 | de Kreutzenberg SV Ceolotto G Papparella I | | 0，，： | 1 |
| 10 | Angiotensin Ⅱ-stimulated collagen production in cardiac fibroblasts is mediated by reactive oxygen species显示文摘 | Lijnen P Papparella I Petrov V | 2006 | J Hypertens2006，24，4： | 1 |
| 11 | Antisperm antibodies in cryptorchidism before and after surgery 显示文摘 | Sinisi AA Pasquali D Papparella A | 1998 | J Urol1998，160，5： | 1 |
| 12 | Downregn- lation of the longevity-associated protein sirtuin 1 in insulin re- sistance and metabolic syndrome: potential biochemical mecha- nisms 显示文摘 | de Kreutzenberg SV Ceolotto G Papparella I | 2010 | Diabetes2010，59，4： | 1 |
| 13 | Interplay between miR-155,AT1R A1166C polymorphism,and AT1R expression in young untreated hypertensives显示文摘 | Ceolotto G Papparella I Bortoluzzi A | 2011 | Am J Hypertens2011，24，： | 1 |
| 14 | Downregulation of the longevity-associated protein sirtuin 1 in insulin resistance and metabolic syndrome:potential biochemical mechanisms显示文摘 | de Kreutzenberg SV Ceolotto G Papparella I | | 0，，4： | 1 |
| 15 | A preliminary vaccine potency trial of a Newcastle Disease Virus inactivated with binary ethylenimine显示文摘 | C. Buonavoglia A. Fioretti M. Tollis F. Menna V. Papparella | 1988 | Veterinary Research Communications (-)1988，，2： | 1 |
| 16 | Interplay between miR-155, ATIR A1166C polymorhism, and AT1R expres- sion in young untreated hypertensives 显示文摘 | Ceolotto G Papparella I Bortoluzzi A | 2011 | Am J Hyper- tens2011，24，2： | 1 |
| 17 | Histochemical and immunohistological approach to comparative neuromuscular diseases 显示文摘 | Paciello O Papparella S | 2009 | Folia His- tochem Cytobiol2009，47，2： | 1 |
| 18 | AngiotensinⅡ-stimulatedcollagen production in cardiac fibroblasts is mediated by reactiveoxygen species显示文摘 | Lijnen P Papparella I Petrov V | 2006 | J Hypertens2006，24，4： | 1 |
| 19 | Green tea attenuates angiotensin H-induced cardiac hypertrophy in rats by modulating reactive oxygen species production and the Sre/epidermal growth factor receptor/Akt signaling pathway显示文摘 | PAPPARELLA I CEOLOTTO G MONTEMURRO D | 2008 | J Nutri2008，138，9： | 1 |
| 20 | Anglotensin I --stimulat- ed collagen pro--duction in cardiac fibroblasts ismediated by reac- tive oxygen species显示文摘 | Lijnen P Papparella I PetrovV eta| | 2006 | J Hypertens2006，24，4： | 1 |
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