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| 1 | Intestinal alkaline phosphatase in the colonic mucosa of children with inflammatory bowel disease显示文摘AIM:To investigate intestinal alkaline phosphatase(iAP) in the intestinal mucosa of children with inflammatory bowel disease(IBD).METHODS:Colonic biopsy samples were taken from 15 newly diagnosed IBD patients and from 10 healthy controls.In IBD patients,specimens were obtainedboth from inflamed and non-inflamed areas.The iAP mRNA and protein expression was determined by reverse transcription-polymerase chain reaction and Western blotting analysis,respectively.Tissue localization of iAP and Toll-like receptor(TLR) 4 was investigated by immunofluorescent staining.RESULTS:The iAP protein level in the inflamed mucosa of children with Crohn's disease(CD) and ulcerative colitis(UC) was significantly decreased when compared with controls(both P < 0.05).Similarly,we found a significantly decreased level of iAP protein in the inflamed mucosa in CD compared with non-inflamed mucosa in CD(P < 0.05).In addition,the iAP protein level in inflamed colonic mucosa in patients with UC was decreased compared with non-inflamed mucosa in patients with CD(P < 0.05).iAP protein levels in the non-inflamed mucosa of patients with CD were similar to controls.iAP mRNA expression in inflamed colonic mucosa of children with CD and UC was not significantly different from that in non-inflamed colonic mucosa with CD.Expression of iAP mRNA in patients with noninflamed mucosa and in controls were similar.Co-localization of iAP with TLR4 showed intense staining with a dotted-like pattern.iAP was present in the inflamed and non-inflamed mucosa of patients with CD,UC,and in control biopsy specimens,irrespective of whether it was present in the terminal ileum or in the colon.However,the fluorescent signal of TLR4 was more pronounced in the colon compared with the terminal ileum in all groups studied.CONCLUSION:Lower than normal iAP protein levels in inflamed mucosa of IBD patients may indicate a role for iAP in inflammatory lesions in IBD.Based on our results,administration of exogenous iAP enzyme to patients with the active form of IBD may be a therapeutic option. | Kriszta Molnár dám Vannay Beáta Szebeni Nóra Fanni Bánki Erna Sziksz ron Cseh Hajnalka Gyrffy Péter László Lakatos Mária Papp András Arató Gábor Veres | 2012 | World Journal of Gastroenterology2012，18，25： | 5 |
| 2 | Involvement of serum retinoids and Leiden mutation in patients with esophageal, gastric, liver, pancreatic, and colorectal cancers in Hungary显示文摘AIM: To analyze the serum levels of retinoids and Leiden mutation in patients with esophageal, gastric, liver,pancreatic, and colorectal cancers.METHODS: The changes in serum levels of retinoids (vitamin A, α- and β-carotene, α- and β-cryptoxanthin,zeaxanthin, lutein) and Leiden mutation were measured by high liquid performance chromatography (HPLC)and polymerase chain reaction (PCR) in 107 patients (70 males/37 females) with esophageal (0/8), gastric (16/5), liver (8/7), pancreatic (6/4), and colorectal (30/21including 9 patients suffering from in situ colon cancer)cancer. Fifty-seven healthy subjects (in matched groups)for controls of serum retinoids and 600 healthy blood donors for Leiden mutation were used.RESULTS: The serum levels of vitamin A and zeaxanthin were decreased significantly in all groups of patients with gastrointestinal (GI) tumors except for vitamin A in patients with pancreatic cancer. No changes were obtained in the serum levels of α- and β-carotene,α- and β-cryptoxanthin, zeaxanthin, lutein in patients with GI cancer. The prevalence of Leiden mutation significantly increased in all groups of patients with GI cancer.CONCLUSION: Retinoids (as environmental factors)are decreased significantly with increased prevalence of Leiden mutation (as a genetic factor) in patients before the clinical manifestation of histologically different (planocellular and hepatocellular carcinoma, and adenocarcinoma) GI cancer. | Gyula Mózsik Gy(o|¨)rgy Rumi András D(o|¨)m(o|¨)t(o|¨)r Mária Figler Beáta Gasztonyi El(?)d Papp Alajos Pár Gabriella Pár József Belágyi Zoltán Matus Béla Melegh | 2005 | World Journal of Gastroenterology2005，11，48： | 2 |
| 3 | Chronic mild stress-induced anhedonia:a realistic animal model of depression显示文摘 | Willner P Muscat R Papp M | | 0，，： | 1 |
| 4 | Increased Ca2+-sensitivity of the contractile apparatus in end-stage human heart failure results from altered phosphorylation of contractile proteins显示文摘 | van der Velden J Papp Z Zaremba R | 2003 | Cardiovasc Res2003，57，1： | 1 |
| 5 | The treatment of moderate to severe psori asis with a new anti-CD11a monoclonalantibody显示文摘 | Papp K Bissonnette R Krueger JG | | 0，，： | 1 |
| 6 | Expression of the carG gene,encoding geranylgeranyl pyrophosphate synthase,is up-regulated by blue light in Mucor circinelloides 显示文摘 | VELAYOS A PAPP T AGUILAR-ELENA R | 2003 | Curr Genet2003，43，2： | 1 |
| 7 | Reversal of stress-induced anhedonia by the atypical antidepressants, fluoxetine and maprotiline显示文摘 | Muscat T R Papp M Willner P | 1992 | Psyckopharmacology(Berl)1992，109，4： | 1 |
| 8 | Localization of chronic Chlamydia psittaci infection in the reproductive tract of sheep显示文摘 | Papp J R Shewen P E | 1996 | J Infect Dis1996，174，6： | 1 |
| 9 | Comparison of pa- ramyxovirus isolates from snakes, lizards and a tortoise 显示文摘 | MARSCHANG R E PAPP T FROST J W | 2009 | Virus Res2009，144，12： | 1 |
| 10 | Analysis of the contribution of Ito to repolarization in canine ventricular myocardium 显示文摘 | Virag L Jost N Papp R | 2011 | Br J Pharma- col2011，164，1： | 1 |
| 11 | A method for the direct analysis of drug compounds in plasma using a single restricted access mate- rial (RAM) column 显示文摘 | Papp R Mullett WM Kwong E | 2004 | J Pharm BiomedAnal2004，36，3： | 1 |
| 12 | Oral apremilast is active in the treatment of moderate to severe plaque psoriasis: results from a phase 2b, randomized, controlled study (PSOR- 005) 显示文摘 | Papp K Hu A Day R | 2011 | JlnvestDermatol2011，131，： | 1 |
| 13 | Nasal-air conditioning in patients with chronic rhinosinusitis and nasal polyposis显示文摘 | Papp J Richard R Keck T | 2008 | Arch Otolaryngol Head Neck Surg2008，134，9： | 1 |
| 14 | Chronic mild stress- induced anhedonia : a realistic animal model of depression 显示文摘 | Willner P Muscat R Papp M | 1992 | Neurosci Biobehav Rev1992，16，4： | 1 |
| 15 | Modification of silica with glucose for the separation of proteins by high-performance liquid chromatography显示文摘 | Huisden R E Kraak J C Pappe H | 1990 | J Chromatogr1990，508，： | 1 |
| 16 | Automatic detection and characterization of funnel chest based on spiral CT显示文摘 | Papp L Juhasz R Travar S | | 0，，02： | 1 |
| 17 | Chronic mild stress-induced anhedonia: a realistic animal model of depression 显示文摘 | Willner P Muscat R Papp M | 1992 | Neurosci Biobehav Rev1992，16，： | 1 |
| 18 | Ion channels and transporters as therapeutic targets in the pulmonary circulation显示文摘 | Olschewski A Papp R Nagataj C | 2014 | Pharmacology & Therapeutics2014，144，3： | 1 |
| 19 | Gap junctional uncoupling plays a trigger role in the antiarrhythmic effect of ischaemic preconditioning显示文摘 | Papp R Gonczi M Kovács M | 2007 | Cardiovascular2007，74，3： | 1 |
| 20 | Chronic mild stress-induced anhedonia: a realistic animal model of depression 显示文摘 | WILLNER P MUSCAT R PAPP M | 1992 | Neurosci Biobehav Rev1992，16，4： | 1 |
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