|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Safety,immunogenicity,and protection provided by unadjuvanted and adjuvanted formulations of a recombinant plant-derived virus-like particle vaccine candidate for COVID-19 in nonhuman primates显示文摘Although antivirals are important tools to control severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection,effective vaccines are essential to control the current coronavirus disease 2019(COVID-19)pandemic.Plant-derived virus-like particle(VLP)vaccine candidates have previously demonstrated immunogenicity and efficacy against influenza.Here,we report the immunogenicity and protection induced in rhesus macaques by intramuscular injections of a VLP bearing a SARS-CoV-2 spike protein(CoVLP)vaccine candidate formulated with or without Adjuvant System 03(AS03)or cytidine-phospho-guanosine(CpG)1018.Although a single dose of the unadjuvanted CoVLP vaccine candidate stimulated humoral and cell-mediated immune responses,booster immunization(at 28 days after priming)and adjuvant administration significantly improved both responses,with higher immunogenicity and protection provided by the AS03-adjuvanted CoVLP.Fifteen micrograms of CoVLP adjuvanted with AS03 induced a polyfunctional interleukin-2(IL-2)-driven response and IL-4 expression in CD4 T cells.Animals were challenged by multiple routes(i.e.,intratracheal,intranasal,and ocular)with a total viral dose of 106 plaque-forming units of SARS-CoV-2.Lower viral replication in nasal swabs and bronchoalveolar lavage fluid(BALF)as well as fewer SARS-CoV-2-infected cells and immune cell infiltrates in the lungs concomitant with reduced levels of proinflammatory cytokines and chemotactic factors in the BALF were observed in animals immunized with the CoVLP adjuvanted with AS03.No clinical,pathologic,or virologic evidence of vaccineassociated enhanced disease was observed in vaccinated animals.The CoVLP adjuvanted with AS03 was therefore selected for vaccine development and clinical trials. | Stéphane Pillet Prabhu SArunachalam Guadalupe Andreani Nadia Golden Jane Fontenot Pyone Pyone Aye Katharina Röltgen Gabrielle Lehmicke Philipe Gobeil Charlotte Dubé Sonia Trépanier Nathalie Charland Marc-AndréD’Aoust Kasi Russell-Lodrigue Christopher Monjure Robert V.Blair Scott D.Boyd Rudolf P.Bohm Jay Rappaport François Villinger Nathalie Landry Bali Pulendran Brian J.Ward | 2022 | Cellular & Molecular Immunology2022，19，2： | 2 |
| 2 | A QP-free globally convergent, locally superlinearly convergent algorithm for inequality constained optimizaiton显示文摘 | Panier E R Tits A L Herskovits J N | 1988 | SIAM Journal on Control and Optimization1988，26，： | 1 |
| 3 | On combining feasibility descent and superlinear convergence in inequality constrained optimization显示文摘 | PANIER E R TITS A L | 1993 | Mathematical Programming1993，59，： | 1 |
| 4 | Double-strand break repair:53BP1comes into focus显示文摘 | PANIER S BOULTON S J | 2014 | Nature Reviews Molecular Cell Biology2014，15，1： | 1 |
| 5 | Infrared characterization of thermal gradients on disc brakes显示文摘 | Stephane Panier Philippe Dufrenoy Pierre Bremond | 2003 | Proc of SPIE2003，5073，： | 1 |
| 6 | On combining feasibility, descent and superlinear convergence in inequality constrained optimization显示文摘 | Eliane R. Panier André L. Tits | 1993 | Mathematical Programming (-)1993，，1： | 1 |
| 7 | Interfacial defeets detection in plasma-sprayed ceramic coating components using two stimulated infrared thermography techniques显示文摘 | Chaki S Marical P Panier S | 2011 | NDT & E International2011，44，6： | 1 |
| 8 | Avoiding the Maratos Effect by Means of a Nonmonotone Line Search I General Constrained Problems显示文摘 | PANIER E R TITS A L | 1991 | SIAM Journal on Numerical Analysis1991，28，4： | 1 |
| 9 | A QP-free,globally,locally superlinear convergent method for the inequality constrained optimization problems显示文摘 | Panier E R Tits A L Herskovits J N | 1988 | SIAM J Control Optim1988，36，： | 1 |
| 10 | Double-strand break repair: 53BP1 comes into focus显示文摘 | Panier S Boulton S J | 2014 | Nat Rev Mol Cell Biol2014，15，1： | 1 |
| 11 | Polyetherimide composites with gamma irradiated carbon fabric :Studies on abrasive wear显示文摘 | Tiwari S Bijwe J Panier S | 2011 | Wear2011，270，910： | 1 |
| 12 | Neuropsychological consequences of chronic bilateral stimulation of the subthalamic nucleus in Parkinson's disease显示文摘 | Saint-Cyr JA Trépanier LL Kumar R | | 0，，： | 1 |
| 13 | Tribological studies on polyetherimide composites based on carbon fabric with optimized oxidation treatment显示文摘 | S. Tiwari J. Bijwe S. Panier | 2011 | Wear2011，，9： | 1 |
| 14 | An Experimental Investigation of Hot Spots in Railway Disc Brakes显示文摘 | Panier S Dufrenoy P Weichert D | 2004 | Wear2004，256，7： | 1 |
| 15 | On combining feasibility, descent and superlinear convergence in inequality constrained optimization显示文摘 | Panier E R Tits A L | 1993 | Mathematical Programming1993，59，1： | 1 |
| 16 | An experimental investigation of hot spots in railway disc brakes显示文摘 | Panier S Dufrenoy P Weichert D | 2004 | Wear2004，256，78： | 1 |
| 17 | Driver-assisted bus interview: passive transit travel survey using smart card automatic fare collection system and its applications显示文摘 | Chu K K Chapleau R Trépanier M | 2009 | Transportation Research Record: Journal of the Transportation Research Board2009，，2105： | 1 |
| 18 | A stoerlinearly convergent feasible method for the solution of inequality constrained optimization problems显示文摘 | Panier E R Tits A L | 1987 | SIAM J Control Optim1987，25，3： | 1 |
| 19 | An experimental investigation of hot spots in railway disc brakes显示文摘 | Panier S Dufrenoy P Weichert D | 2004 | Wear2004，256，： | 1 |
| 20 | The Capacitated Arc Routing Problem with Refill Points显示文摘 | Amaya A Langevin A Trépanier M | | 0，，03： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员