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| 1 | Contribution of a new,rapid,quantitative and automated method for D-di-mer measurement to exclude deep vein thrombosis in symptomatic outpatients显示文摘 | Legnani C Pancani C Palareti G | | 0，，2： | 1 |
| 2 | Pharmacological inhibition of histone deacetylases by suberoylanilide hydroxamic acid specifically alters gene expression and reduces ischemic injury in the mouse brain 显示文摘 | FARACO G PANCANI T FORMENTINI L | 2006 | Mol Pharmacol2006，70，6： | 1 |
| 3 | Intracanlal araehnoid cyst in pediatric age显示文摘 | Cagnoni G Fonda C Pancani S | 1996 | Pediat Med Chit1996，18，1： | 1 |
| 4 | The evolution of adaptive imminity显示文摘 | PANCANIER Z COOPER M D | 2006 | Annual Review of Immunology2006，24，： | 1 |
| 5 | Intracranial arachnoid cyst in pediatric age显示文摘 | Cagnoni G Fonda C Pancani S | 1996 | Pediat Med Chir1996，18，1： | 1 |
| 6 | Intracranial arachnoid cysts in pediatric age显示文摘 | Cagnoni G Fonda C Pancani S | 1996 | Pediat Med Chir1996，18，： | 1 |
| 7 | Distinct modulation of voltage-gated and ligand-gated Ca2+ currents by PPAR-gamma agonists in cultured hippocampal neurons显示文摘 | Pancani T Phelps JT Searcy JL | 2009 | J Neurochem2009，109，： | 1 |
| 8 | Congenital anomalies of the penis in children(A few consideration about 92 cases)显示文摘 | Abbate B Danti DA Pancani S | 1994 | Minerva Pediatr1994，46，： | 1 |
| 9 | Intracranial arachnoid cyst in pediatric age 显示文摘 | Cagnoni G Fonda C Pancani S | 1996 | Pendiat Med Chir1996，18，1： | 1 |
| 10 | Pharmaco-logical inhibition of histone deacetylases by suberoylanilidehydroxamic acid specifically alters gene expression and reduces is-chemic injury in the mouse brain显示文摘 | FARACO G PANCANI T FORMENTINI L | 2006 | Mol Pharmacol2006，70，6： | 1 |
| 11 | Intracranial arachnoid cyst in pediatric age 显示文摘 | Fonda C Pancani S | 1996 | Pediat Med Chir1996，18，1： | 1 |
| 12 | When and how to restore β-cell function显示文摘 | PANCANI F LUPI R MICCOLI R | 2007 | Intern Congress Series2007，，1303： | 1 |
| 13 | Intracranial arachnoid cyst in pediatric age显示文摘 | Cagnoni G Fonda C Pancani S | 1996 | Pediatr Med Chir1996，18，1： | 1 |
| 14 | Neuroprotective Effects of Propofol in Models of Cerebral Ischemia: Inhibition of Mitochondrial Swelling as a Possible Mechanism显示文摘 | Chiara Adembri Luna Venturi Alessia Tani Alberto Chiarugi Elena Gramigni Andrea Cozzi Tristano Pancani Raffaele A. De Gaudio Domenico E. Pellegrini-Giampietro | 2006 | Anesthesiology2006，，1： | 1 |
| 15 | Pharmacological inhibition of histone deacetylases by suberoylanilide hydroxamic acid specifically alters gene expression and reduces ischemic injury in the mouse brain显示文摘 | Faraco G Pancani T Formentini L | 2006 | Mol Phannaco12006，70，6： | 1 |
| 16 | Pharmacological inhibition of histone deacetylases by suberoylanilide hydroxamic acid specifically alters gene expression and reduces ischemic injury in the mouse brain显示文摘 | Faraco G Pancani T Formentini L | 2006 | Mol Pharmacol2006，70，6： | 1 |
| 17 | Intracranial arachnoid cyst in pediatric age显示文摘 | Cagnoni G Fonda C Pancani S | 1996 | Pediat Med Chir1996，18，： | 1 |
| 18 | Nanoparticles with high payloads of pipemidic acid, a poorly soluble crystalline drug: drug-initiated polymerization and self-assembly approach显示文摘Nowadays, biodegradable polymers such as poly(lactic acid)(PLA), poly(D,L-lactic-coglycolic acid)(PLGA) and poly(ε-caprolactone)(PCL) remain the most common biomaterials to produce drug-loaded nanoparticles(NPs). Pipemidic acid(PIP) is a poorly soluble antibiotic with a strong tendency to crystallize. PIP incorporation in PLA/PLGA NPs was challenging because of PIP crystals formation and burst release. As PIP had a poor affinity for the NPs, an alternative approach to encapsulation was used, consisting in coupling PIP to PCL. Thus, a PCL–PIP conjugate was successfully synthesized by an original drug-initiated polymerization in a single step without the need of catalyst.PCL–PIP was characterized by NMR, IR, SEC and mass spectrometry. PCL–PIP was used to prepare selfassembled NPs with PIP contents as high as 27%(w/w). The NPs were characterized by microscopy,DLS, NTA and TRPS. This study paves the way towards the production of NPs with high antibiotic payloads by drug-initiated polymerization. Further studies will deal with the synthesis of novel polymer–PIP conjugates with ester bonds between the drug and PCL. PIP can be considered as a model drug and the strategy developed here could be extended to other challenging antibiotics or anticancer drugs and employed to efficiently incorporate them in NPs. | Elisabetta Pancani Mario Menendez-Miranda Alexandra Pastor Francois Brisset Marie-Francoise Bernet-Camard Didier Desmaele Ruxandra Gref | 2018 | Acta Pharmaceutica Sinica B2018，8，3： | 0 |
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