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| 1 | International consensus statement on robotic hepatectomy surgery in 2018显示文摘The robotic surgical system has been applied in liver surgery. However,controversies concerns exist regarding a variety of factors including the safety,feasibility, efficacy, and cost-effectiveness of robotic surgery. To promote the development of robotic hepatectomy, this study aimed to evaluate the current status of robotic hepatectomy and provide sixty experts' consensus and recommendations to promote its development. Based on the World Health Organization Handbook for Guideline Development, a Consensus Steering Group and a Consensus Development Group were established to determine the topics, prepare evidence-based documents, and generate recommendations. The GRADE Grid method and Delphi vote were used to formulate the recommendations. A total of 22 topics were prepared analyzed and widely discussed during the 4 meetings. Based on the published articles and expert panel opinion, 7 recommendations were generated by the GRADE method using an evidence-based method, which focused on the safety, feasibility, indication,techniques and cost-effectiveness of hepatectomy. Given that the current evidences were low to very low as evaluated by the GRADE method, further randomized-controlled trials are needed in the future to validate these recommendations. | Rong Liu Go Wakabayashi Hong-Jin Kim Gi-Hong Choi Anusak Yiengpruksawan Yuman Fong Jin He Ugo Boggi Roberto I Troisi Mikhail Efanov Daniel Azoulay Fabrizio Panaro Patrick Pessaux Xiao-Ying Wang Ji-Ye Zhu Shao-Geng Zhang Chuan-Dong Sun Zheng Wu Kai-Shan Tao Ke-Hu Yang Jia Fan Xiao-Ping Chen | 2019 | World Journal of Gastroenterology2019,25,12: | 23 |
| 2 | Liver venous deprivation versus portal vein embolization before major hepatectomy:future liver remnant volumetric and functional changes显示文摘Background:We previously showed that embolization of portal inflow and hepatic vein(HV)outflow(liver venous deprivation,LVD)promotes future liver remnant(FLR)volume(FLR-V)and function(FLR-F)gain.Here,we compared FLR-V and FLR-F changes after portal vein embolization(PVE)and LVD.Methods:This study included all patients referred for liver preparation before major hepatectomy over 26 months.Exclusion criteria were:unavailable baseline/follow-up imaging,cirrhosis,Klatskin tumor,two-stage hepatectomy.99mTc-mebrofenin SPECT-CT was performed at baseline and at day 7,14 and 21 after PVE or LVD.FLR-V and FLR-F variations were compared using multivariate generalized linear mixed models(joint modelling)with/without missing data imputation.Results:Baseline FLR-F was lower in the LVD(n=29)than PVE group(n=22)(P<0.001).Technical success was 100%in both groups without any major complication.Changes in FLR-V at day 14 and 21(+14.2%vs.+50%,P=0.002;and+18.6%vs.+52.6%,P=0.001),and in FLR-F at day 7,14 and 21(+23.1%vs.+54.3%,P=0.02;+17.6%vs.+56.1%,P=0.006;and+29.8%vs.+63.9%,P<0.001)differed between PVE and LVD group.LVD(P=0.009),age(P=0.027)and baseline FLR-V(P=0.001)independently predicted FLR-V variations,whereas only LVD(P=0.01)predicted FLR-F changes.After missing data handling,LVD remained an independent predictor of FLR-V and FLR-F variations.Conclusions:LVD is safe and provides greater FLR-V and FLR-F increase than PVE.These results are now evaluated in the HYPERLIV-01 multicenter randomized trial. | Boris Guiu François Quenet Fabrizio Panaro Lauranne Piron Christophe Cassinotto Astrid Herrerro François-Régis Souche Margaux Hermida Marie-Ange Pierredon-Foulongne Ali Belgour Serge Aho-Glele Emmanuel Deshayes | 2020 | Hepatobiliary Surgery and Nutrition2020,9,5: | 10 |
| 3 | Risk factors for postoperative bile leakage:a retrospective single-center analysis of 411 hepatectomies显示文摘BACKGROUND: The primary focus of the study was to analyze the risk factors for bile leakage after hepatectomy for benign or malignant tumors. METHODS: A total of 411 patients who had undergone hepatectomy between December 2006 and December 2011 were retrospectively analyzed. The severity of bile leakage was graded according to the ISGLS classification. Twenty-eight pre- and postoperative parameters were analyzed.RESULTS: The overall bile leakage incidence was 10.2%(42/411). The severity of the leakage was classified according to the ISGLS classification. Bile leakage was detected early in case of abdominal drainage(11.4% vs 1.9%, P=0.034). It prolonged the time of hospitalization(16 vs 9 days, P=0.001). In all patients, wedge resection was associated with a higher incidence of bile leakage in contrast to anatomical resections(25.6% vs 4.1%, P<0.0001) regardless of the underlying liver disease. Furthermore, total vascular exclusion increased risk of bile leakage(P=0.008).CONCLUSIONS: Bile leakage as a major issue after hepatic resection is related to the postoperative morbidity and the hospitalization time. It is associated with non-anatomical resection and a total vascular exclusion. | Fabrizio Panaro Lisa Hacina Hassan Bouyabrine Al-Warith Al-Hashmi Astrid Herrero Francis Navarro | 2016 | Hepatobiliary & Pancreatic Diseases International2016,15,1: | 10 |
| 4 | Optimization of the future remnant liver:review of the current strategies in Europe显示文摘Liver resection still represent the treatment of choice for liver malignancies,but in some cases inadequate future remnant liver(FRL)can lead to post hepatectomy liver failure(PHLF)that still represents the most common cause of death after hepatectomy.Several strategies in recent era have been developed in order to generate a compensatory hypertrophy of the FRL,reducing the risk of post hepatectomy liver failure.Portal vein embolization,portal vein ligation,and ALLPS are the most popular techniques historically adopted up to now.The liver venous deprivation and the radio-embolization are the most recent promising techniques.Despite even more precise tools to calculate the relationship among volume and function,such as scintigraphy with^(99m)Tc-mebrofenin(HBS),no consensus is still available to define which of the above mentioned augmentation strategy is more adequate in terms of kind of surgery,complexity of the pathology and quality of liver parenchyma.The aim of this article is to analyse these different strategies to achieve sufficient FRL. | Riccardo Memeo Maria Conticchio Emmanuel Deshayes Silvio Nadalin Astrid Herrero Boris Guiu Fabrizio Panaro | 2021 | Hepatobiliary Surgery and Nutrition2021,10,3: | 4 |
| 5 | Radio Electric Asymmetric Conveyer Technology Modulates Neuroinflammation in a Mouse Model of Neurodegeneration显示文摘In this study, the effects of Radio Electric Asymmetric Conveyer(REAC), a non-invasive physical treatment, on neuroinflammatory responses in a mouse model of parkinsonism induced by intoxication with1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP),were investigated in vivo. We found that the REAC tissue optimization treatment specific for neuro-regenerative purposes(REAC TO-RGN-N) attenuated the inflammatory picture evoked by MPTP-induced nigro-striatal damage inmice, decreasing the levels of pro-inflammatory molecules and increasing anti-inflammatory mediators. Besides, there was a significant reduction of both astrocyte and microglial activation in MPTP-treated mice exposed to REAC TORGN-N. These results indicated that REAC TO-RGN-N treatment modulates the pro-inflammatory responses and reduces neuronal damage in MPTP-induced parkinsonism. | Maria Antonietta Panaro Alessandra Aloisi Giuseppe Nicolardi Dario Domenico Lofrumento Francesco De Nuccio Velia La Pesa Antonia Cianciulli Rosaria Rinaldi Rosa Calvello Vania Fontani Salvatore Rinaldi | 2018 | Neuroscience Bulletin2018,34,2: | 3 |
| 6 | International experts consensus guidelines on robotic liver resection in 2023显示文摘The robotic liver resection(RLR)has been increasingly applied in recent years and its benefits shown in some aspects owing to the technical advancement of robotic surgical system,however,controversies still exist.Based on the foundation of the previous consensus statement,this new consensus document aimed to update clinical recommendations and provide guidance to improve the outcomes of RLR clinical practice.The guideline steering group and guideline expert group were formed by 29 international experts of liver surgery and evidence-based medicine(EBM).Relevant literature was reviewed and analyzed by the evidence evaluation group.According to the WHO Handbook for Guideline Development,the Guidance Principles of Development and Amendment of the Guidelines for Clinical Diagnosis and Treatment in China 2022,a total of 14 recommendations were generated.Among them were 8 recommendations formulated by the GRADE method,and the remaining 6 recommendations were formulated based on literature review and experts’opinion due to insufficient EBM results.This international experts consensus guideline offered guidance for the safe and effective clinical practice and the research direction of RLR in future. | Rong Liu Mohammed Abu Hilal Go Wakabayashi Ho-Seong Han Chinnusamy Palanivelu Ugo Boggi Thilo Hackert Hong-Jin Kim Xiao-Ying Wang Ming-Gen Hu Gi Hong Choi Fabrizio Panaro Jin He Mikhail Efanov Xiao-Yu Yin Roland S Croner Yu-Man Fong Ji-Ye Zhu Zheng Wu Chuan-Dong Sun Jae Hoon Lee Marco V Marino Iyer Shridhar Ganpati Peng Zhu Zi-Zheng Wang Ke-Hu Yang Jia Fan Xiao-Ping Chen Wan Yee Lau | 2023 | World Journal of Gastroenterology2023,29,32: | 2 |
| 7 | Rubber transcystic drainage reduces the post-removal biliary complications in liver transplantation:a matched case-control study显示文摘 | Panaro F Glaise A Miggino M | 2013 | Langenbecks Arch Surg2013,398,1: | 1 |
| 8 | Preliminary experience with the hanging maneuver for pancreaticoduodenectomy显示文摘 | Pessaux P Rosso E Panaro F | 2009 | Eur J Surg Oncol2009,35,9: | 1 |
| 9 | Preliminary experience with the hanging maneuver for pancreaticoduodenectomy显示文摘 | Pessaux P Rosso E Panaro F | 2009 | Eur J Surq Oncol2009,35,9: | 1 |
| 10 | Evidenees for iNOS Expression and Nitric Oxide Production in the Human Macrophages 显示文摘 | Panaro MA Brandonisio O Acquafredda A | 2003 | Curr Drug Targets Immune Endoer Metabol Disord2003,3,3: | 1 |
| 11 | Agilent 2100 Bioanalyzer for restriction fragment length polymorphism analysis of the Campylobacter jejuni flagellin gene 显示文摘 | Nachamkin I Panaro NJ Li M | 2001 | J Clin Microbiol2001,39,2: | 1 |
| 12 | Preliminary experience with the hanging maneuver for pancreaticoduodenectomy 显示文摘 | Pessaux P Rosso E Panaro F | 2009 | Eur J Surg Oncol2009,35,9: | 1 |
| 13 | Evidences for iNOS expression and nitric oxide production in the human maerophages 显示文摘 | Panaro MA Brandonisio O Acquafredda A | 2003 | Curr Drug Targets Immune Endocr Metabol Disord2003,3,3: | 1 |
| 14 | Are the Hangzhou Criteria adaptable to hepatocellular carcinoma patients for liver transplantation in western countries显示文摘 | AUDET M PANARO F PIARDI T | | 0,,7: | 1 |
| 15 | Identification of ubiquitin ligases required for skeletal muscle at-roohy 显示文摘 | Bodine SC Latres E Baumhueter S Lai VK Nunez L Clarke BA Poueymirou WT Panaro FJ Na E Dharmarajan K Pan ZQ Valenzuela DM DeChiara TM Stitt TN Yancopoulos GD Glass DJ | 2001 | Science2001,294,5547: | 1 |
| 16 | Risk Factors for Liver Failure and Mortality After Hepatectomy Associated With Portal Vein Resection显示文摘 | Philippe Bachellier Edoardo Rosso Patrick Pessaux Elie Oussoultzoglou Cinzia Nobili Fabrizio Panaro Daniel Jaeck | 2011 | Annals of Surgery2011,,1: | 1 |
| 17 | Evidences for iNOS expression and nitric oxide production in the human macrophages显示文摘 | PANARO MA BRANDONISIO O ACQUAFREDDA A | 2003 | Curr Drug Targets Immune Endocr Metabol Disord2003,3,3: | 1 |
| 18 | Outcome of laparoscopic splenectomy for malignant hematologic diseases显示文摘 | Cavaliere D Torelli P Panaro F | 2004 | Tumori2004,90,2: | 1 |
| 19 | Laparoscopic Ultrasound-Guided Radiofrequency Ablation as a Bridge to Liver Transplantation for Hepatocellular Carcinoma:Preliminary Results显示文摘 | Panaro F Piardi T Audet M | 2010 | Transplant Proc2010,42,4: | 1 |
| 20 | Current opinions and perspectives on the role of immune system in the pathogenesis of Parkinson's disease 显示文摘 | Panaro MA Cianciulli A | 2012 | Curr Pharm Des2012,18,2: | 1 |