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| 1 | Nuclear medicine and the failed joint replacement: Past, present, and future显示文摘Soon after the introduction of the modern prosthetic joint,it was recognized that radionuclide imaging provides useful information about these devices.The bone scan was used extensively to identify causes of prosthetic joint failure.It became apparent,however,that although sensitive,regardless of how the images were analyzed or how it was performed,the test was not specific and could not distinguish among the causes of prosthetic failure.Advances in anatomic imaging,notably cross sectional modalities,have facilitated the diagnosis of many,if not most,causes of prosthetic failure,with the important exception of infection.This has led to a shift in the diagnostic paradigm,in which nuclear medicine investigations increasingly have focused on diagnosing infection.The recognition that bone scintigraphy could not reliably diagnose infection led to the development of combined studies,first bone/gallium and subsequently leukocyte/bone and leukocyte/marrow imaging.Labeled leukocyte imaging,combined with bone marrow imaging is the most accurate(about90%)imaging test for diagnosing joint arthroplasty infection.Its value not withstanding,there are significant disadvantages to this test.In-vivo techniques for labeling leukocytes,using antigranulocyte antibodieshave been explored,but have their own limitations and the results have been inconsistent.Fluorodeoxyglucose(FDG)-positron emission tomography(FDG-PET)has been extensively investigated for more than a decade but its role in diagnosing the infected prosthesis has yet to be established.Antimicrobial peptides bind to bacterial cell membranes and are infection specific.Data suggest that these agents may be useful for diagnosing prosthetic joint infection,but large scale studies have yet to be undertaken.Although for many years nuclear medicine has focused on diagnosing prosthetic joint infection,the advent of hybrid imaging with singlephoton emission computed tomography(SPECT)/electronic computer X-ray tomography technique(CT)and the availability of fluorine-18 fluoride PET suggests that the diagnostic paradigm may be shifting again.By providing the anatomic information lacking in conventional radionuclide studies,there is renewed interest in bone scintigraphy,performed as a SPECT/CT procedure,for detecting joint instability,mechanical loosening and component malpositioning.Fluoride-PET may provide new insights into periprosthetic bone metabolism.The objective of this manuscript is to provide a comprehensive review of the evolution of nuclear medicine imaging of joint replacements. | Christopher J Palestro | 2014 | World Journal of Radiology2014，6，7： | 5 |
| 2 | Prevalence of Helicobacter pylori infection and intestinal metaplasia in subjects who had undergone surgery for gastric adenocarcinoma in Northwest Italy显示文摘AIM: To investigate the seroprevalence of Helicobacter pylori(H pylorri) infection and its more virulent strains as well as the correlation with the histologic features among patients who had undergone surgery for gastric cancer (GC).METHODS: Samples from 317 (184 males, 133females, mean age 69±3.4 years) consecutive patients who had undergone surgery for gastric non-cardia adenocarcinoma were included in the study. Five hundred and fifty-five (294 males, 261 females, mean age 57.3±4.1 years) patients consecutively admitted to the Emergency Care Unit served as control. Histological examination of tumor, lymph nodes and other tissues obtained at the time of surgery represented the diagnostic 'gold standard'. An enzyme immunosorbent assay was used to detect serum anti-H pylori(IgG)antibodies and Western blotting technique was utilized to search for anti-CagA protein (IgG).RESULTS: Two hundred and sixty-one of three hundred and seventeen (82.3%) GC patients and 314/555 (56.5%)controls were seropositive for anti-H pylori (P<0.0001;OR, 3.58; 95%CI, 2.53-5.07). Out of the 317 cases, 267(84.2%) were seropositive for anti-CagA antibody vs 100 out of 555 (18%) controls (P<0.0001; OR, 24.30;95%CI, 16.5-35.9). There was no difference between the frequency of H pyloriin intestinal type carcinoma (76.2%) and diffuse type cancer (78.8%). Intestinal metaplasia (IM) was more frequent but not significant in the intestinal type cancer (83.4% vs 75.2% in diffuse type and 72.5% in mixed type). Among the patients examined for IM, 39.8% had IM type Ⅰ, 8.3% type Ⅱ and 51.9% type Ⅲ (type Ⅲ vs others, P = 0.4).CONCLUSION; This study confirms a high seroprevalence of H pyloriinfection in patients suffering from gastric adenocarcinoma and provides further evidence that searching for CagA status over H pylori infection might confer additional benefit in identifying populations at greater risk for this tumor. | Giorgio Palestro Rinaldo Pellicano Gian Ruggero Fronda Guido Valente Marco De Giuli Tito Soldati Agostino Pugliese Stefano Taraglio Mauro Garino Donata Campra Miguel Angel Cutufia Elena Margaria Giancarlo Spinzi Aldo Ferrara Giorgio Marenco Mario Rizzetto Antonio Ponzetto | 2005 | World Journal of Gastroenterology2005，11，45： | 5 |
| 3 | Nuclear Medicine and the Infected Joint Replacement显示文摘 | Charito Love Scott E. Marwin Christopher J. Palestro | 2009 | Seminars in Nuclear Medicine2009，，1： | 1 |
| 4 | Imaging of musculoskeletal infections显示文摘 | Christopher J. Palestro | 2006 | Best Practice & Research Clinical Rheumatology2006，，6： | 1 |
| 5 | Immunohistological evidences of cortical and medullary differentiation in thymoma显示文摘 | Muller-Hermelink HK Marino M Palestro G | 1985 | Virchows Arch A Pathol Anat Histopathol1985，408，23： | 1 |
| 6 | Radionuclide imaging of spinal infections显示文摘 | Gemmel F Dumarey N Palestro C J | 2006 | Eur J Nucl Med Mol Imaging2006，33，10： | 1 |
| 7 | Radionuclide imaging of the parathyroid glands 显示文摘 | Palestro CJ Tomas MB Tronco GG | 2005 | Semin Nucl Med2005，35，4： | 1 |
| 8 | Expanding role of 18F-fluoro-d-deoxyglucose PET and PET/CT in spinal infections显示文摘 | Filip Gemmel Paul C. Rijk James M. P. Collins Thierry Parlevliet Katrin D. Stumpe Christopher J. Palestro | 2010 | European Spine Journal2010，，4： | 1 |
| 9 | Radionclide imaging after skeletal interventional procedures显示文摘 | Palestro CJ | 1995 | Semin Nucl Ned1995，25，1： | 1 |
| 10 | Infected knee prosthesis: diagnosis with In-111 leukocyte, Tc-99m sulfur colloid, and Tc- 99m MDP imaging显示文摘 | Palestro CJ Swyer AJ Kim CK | 1991 | Radiology1991，179，3： | 1 |
| 11 | Relationships between blood pool and myocardial perfusion-gated SPECT global and regional left ventricular function measurements显示文摘 | Kenneth J. Nichols Andrew Van Tosh Yi Wang Ji Chen Ernest V. Garcia Christopher J. Palestro Nathaniel Reichek | 2009 | Nuclear Medicine Communications2009，，4： | 1 |
| 12 | Radionuclide imaging of the parathyroid glands显示文摘 | Palestro CJ Tomas MB Tronco GG | 2005 | Semin Nucl Med2005，35，4： | 1 |
| 13 | Total hip arthroplasty:periprosthetic indium-111-labelled leukocyte activity and complementary technetium 99-m-sulfur colloid imaging in suspected imageing显示文摘 | Kim CK Swyer AJ | 1990 | J Nucl Med1990，31，： | 1 |
| 14 | Casfleman disease显示文摘 | Palestro G Turrini F Pagano M | 1999 | Adv Clin Path1999，3，12： | 1 |
| 15 | Immunohistologic evidences of cortical and medullary differentiation in thymoma显示文摘 | Mtiller-Hermelink HK Marino M Palestro G | 1985 | Virchows Arch1985，408，： | 1 |
| 16 | Pathology of thymic epithelial tumors显示文摘 | Mtiller- Hermelink HK Marino M Palestro G | 1986 | Curr Top Pathol1986，75，： | 1 |
| 17 | Radionuclide imaging of spinal infections显示文摘 | Filip Gemmel Nicolas Dumarey Christopher J. Palestro | 2006 | European Journal of Nuclear Medicine and Molecular Imaging2006，，10： | 1 |
| 18 | Combined labeled leukocyte and technetium 99m sulfur colloid bone mar- row imaging for diagnosing musculoskeletal infection显示文摘 | Palestro C J Love C Tronco GG | 2006 | Radiographics2006，26，6： | 1 |
| 19 | Tc-99m P483H for imaging infection: phase 2 muhicenter trim resuhs 显示文摘 | Palestro CJ Tomas MB Bhargava KK | 1999 | J Nucl Med1999，40，5： | 1 |
| 20 | Radionuclide Imaging of Inflammation and Infection in the Acute Care Setting显示文摘 | Charito Love Christopher J. Palestro | 2012 | Seminars in Nuclear Medicine2012，，： | 1 |
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