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| 1 | A family study of endophenotypes for psychosis within an early intervention programme in Hong Kong: Rationale and preliminary findings显示文摘The study of endophenotypes may be a viable strategy to tackle the genetic complexity and phenotypic heterogeneity of psychosis, but this research direction is relatively under-developed in China as compared to Western countries. We have recently initiated one of the first family studies of endophenotypes for psychosis in China. Patients entering an established early psychosis intervention service are recruited into this research project for phenotyping, endophenotyping and genotyping. At the endophenotypic level, four domains (neurological soft signs, neurocognition of prospective memory, social cognition of facial emotion recognition, and affective cognition of anticipatory and consummatory pleasure) are studied in the sample of patients with psychosis and their unaffected siblings. This article illustrates the benefit of a research-oriented clinical programme and its findings based on the data collected as of early 2011. | LUI Simon S Y SHAM Pak CHAN Raymond C K CHEUNG Eric F C | 2011 | Chinese Science Bulletin2011，56，32： | 2 |
| 2 | Statistical issues and approaches in endophenotype research显示文摘The endophenotype concept was initially proposed to enhance the power of genetic studies of complex disorders. It is closely related to the genetic component in a liability-threshold model; a perfect endophenotype should have a correlation of 1 with the genetic component of the liability to disease. In reality, a putative endophenotype is unlikely to be a perfect representation of the genetic component of disease liability. The magnitude of the correlation between a putative endophenotype and the genetic component of disease liability can be estimated by fitting multivariate genetic models to twin data. A number of statistical methods have been developed for incorporating endophenotypes in genetic linkage and association analyses with the aim of improving statistical power. The most recent of such methods can handle multiple endophenotypes simultaneously for the greatest increase in power. In addition to increasing statistical power, endophenotype research plays an important role in helping to understand the mechanisms which connect the associated genetic variants with disease occurrence. Novel statistical approaches may be required for the analysis of the complex relationships between endophenotypes at different levels and how they converge to cause the occurrence of disease. | SHAM Pak Chung CHERNY Stacey S HALL Mei-Hua | 2011 | Chinese Science Bulletin2011，56，32： | 2 |
| 3 | Steady-state conversion of methane to C4+ aliphatic products in high yields using an integrated recycle reactor system显示文摘 | Pak S Rades T Rosynek M P Lunsford J H | | 0，，： | 2 |
| 4 | The human vitamin D receptor gene(VDR) is localized to region 12cen-ql2 by fluorescent in situ hybridization and radiation hybrid mapping: genetic and physical VDR map显示文摘 | Taymans SE Pack S Pak E | 1999 | J Bone Miner Res1999，14，7： | 1 |
| 5 | Oxidative stress transiently decreases the IKK complex,an upstream component of NF-κB signaling,after transient focal cerebral ischemia in mice显示文摘 | YUN S SONG YONG-SUN LEE PAK H CHAN | 2005 | J Cereb Blood Flow Metab2005，25，： | 1 |
| 6 | Assessment of a bioactive compound for its potential anti-inflammatory property by tight junction permeability显示文摘 | BSi Y H Pak S C Lee S H | | 0，，： | 1 |
| 7 | Duty cycle allocation to maximize network lifetime of wireless sensor networks with delay constraints显示文摘 | Pak W Choi Jin G Bahk S | 2014 | Wireless Communications&Mobile Computing2014，14，6： | 1 |
| 8 | Sexually transmitted infec- tions among pregnant women attending antenatal clinics in Mongolia: potential impact on the Mongolian HIV epidemic显示文摘 | Amindavaa O Kristensen S Pak CY | 2005 | Int J STD AIDS2005，16，2： | 1 |
| 9 | A morphometric analysis of infraspecific taxa within the lxeris chinensis complex ( Asteraceae, Lactuceae) 显示文摘 | Whang S S Choi K Hill R S Pak J H | 2002 | Bot Bull Acad Sin2002，43，： | 1 |
| 10 | A framework of knowledge transfer in cross - border joint ventures : An empirical test of the Korean context 显示文摘 | PAK Y S PARK Y | 2004 | Management International Review2004，，4： | 1 |
| 11 | Three-dimensional wave propaga- tion analysls of a smoothly heterogeneous solid 显示文摘 | PAK R Y S GUZINA B B | 1995 | Journal of the Mechanics and Physics of Solids1995，43，4： | 1 |
| 12 | The Effect of Calcium Addition to Magnesium on the Microstructure and Compositional Changes of Oxide Film Formed at High Temperature 显示文摘 | You B S Pak W W Chung I S | 2001 | Materials Transactions JIM2001，42，6： | 1 |
| 13 | Impact of postoperative na- dir hemoglobin and blood transfusion on outcomes after opera tions for atherosclerotic vascular disease 显示文摘 | Kougias P Orcutt S Pak T | 2013 | J Vasc Surg2013，57，5： | 1 |
| 14 | Wavelet transform-based stress-time history editing of horizontal axis wind tur bine blades显示文摘 | PANU PRATUMNOPHARAT PAK SING LEUNG RICHARD S COURT | | 0，，： | 1 |
| 15 | Beta - receptors increase cAMP and induce abnormal Ca^2+ cycling in the German shepherd sudden death model显示文摘 | Steinberg SF Alcott S Pak E | 2002 | Am J Physiol2002，282，4： | 1 |
| 16 | Three-dimensional Green’sfunctions for a multilayered half-space in displacementpotentials 显示文摘 | Pak R Y S Guzina B | 2002 | Journal of Engineering Mechanics2002，128，4： | 1 |
| 17 | Palladium-decorated hydrogen-gas sensors using periodically aligned graphene nanoribbons 显示文摘 | PAK Y KIM S M JEONG H | 2014 | ACS applied materials & interfaces2014，6，13： | 1 |
| 18 | Five-port Equivalent Electric Circuit of Piezoelectric Bimorph Beam显示文摘 | Co J S Pak E Jeong H M Sung K H | 1999 | Proceedings of the SPIE -the International Society for Optical Engineering1999，，29： | 1 |
| 19 | Variations in the nucleocapsid protein gene of infectious bronchitis viruses isolated in Korea显示文摘 | PARK J Y PAK S l SUNG H W | 2005 | Virus Genes2005，31，2： | 1 |
| 20 | Properties enhancement of fluorosilicone elastomers with compatibilised crystalline cinylidene fluoride Polymers显示文摘 | L Mascia S H Pak G Caporiccio | 1995 | Europe Polymer1995，31，： | 1 |
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