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| 1 | Rational use of mesenchymal stem cells in the treatment of autism spectrum disorders显示文摘Autism and autism spectrum disorders(ASD) refer to a range of conditions characterized by impaired social and communication skills and repetitive behaviors caused by different combinations of genetic and environmental influences. Although the pathophysiology underlying ASD is still unclear, recent evidence suggests that immune dysregulation and neuroinflammation play a role in the etiology of ASD. In particular, there is direct evidence supporting a role for maternal immune activation during prenatal life in neurodevelopmental conditions. Currently, the available options of behavioral therapies and pharmacological and supportive nutritional treatments in ASD are only symptomatic. Given the disturbing rise in the incidence of ASD, and the fact that there is no effective pharmacological therapy for ASD, there is an urgent need for new therapeutic options. Mesenchymal stem cells(MSCs) possess immunomodulatory properties that make them relevant to several diseases associated with inflammation and tissue damage. The paracrine regenerative mechanisms of MSCs are also suggested to be therapeutically beneficial for ASD.Thus the underlying pathology in ASD, including immune system dysregulation and inflammation, represent potential targets for MSC therapy. This review willfocus on immune dysfunction in the pathogenesis of ASD and will further discuss the therapeutic potential for MSCs in mediating ASD-related immunological disorders. | Qiang Liu Mo-Xian Chen Lin Sun Chloe U Wallis Jian-Song Zhou Li-Juan Ao Qi Li Pak C Sham | 2019 | World Journal of Stem Cells2019，11，2： | 5 |
| 2 | A family study of endophenotypes for psychosis within an early intervention programme in Hong Kong: Rationale and preliminary findings显示文摘The study of endophenotypes may be a viable strategy to tackle the genetic complexity and phenotypic heterogeneity of psychosis, but this research direction is relatively under-developed in China as compared to Western countries. We have recently initiated one of the first family studies of endophenotypes for psychosis in China. Patients entering an established early psychosis intervention service are recruited into this research project for phenotyping, endophenotyping and genotyping. At the endophenotypic level, four domains (neurological soft signs, neurocognition of prospective memory, social cognition of facial emotion recognition, and affective cognition of anticipatory and consummatory pleasure) are studied in the sample of patients with psychosis and their unaffected siblings. This article illustrates the benefit of a research-oriented clinical programme and its findings based on the data collected as of early 2011. | LUI Simon S Y SHAM Pak CHAN Raymond C K CHEUNG Eric F C | 2011 | Chinese Science Bulletin2011，56，32： | 2 |
| 3 | Pharmacotherapy of kidney stones显示文摘 | Pak C Y | 2008 | Expert Opin Pharmacother2008，9，9： | 1 |
| 4 | Assessment of a bioactive compound for its potential anti-inflammatory property by tight junction permeability显示文摘 | BSi Y H Pak S C Lee S H | | 0，，： | 1 |
| 5 | Feasibility of producing ethanol from food waste 显示文摘 | KIM J H LEE J C PAK D | 2011 | Waste Management2011，31，9： | 1 |
| 6 | Effect of particle size distribution and chlorophyll content on beam attenuation spectra 显示文摘 | J C Kitchen J R V Zaneveld H Pak | 1982 | Appl Opt1982，21，21： | 1 |
| 7 | Wing shape sensing from measured strain显示文摘 | PAK C G | 2016 | AIAA2016，54，3： | 1 |
| 8 | Construction and characterization of the soybean leaf metalloproteinase cDNA显示文摘 | PAK J H LIU C Y HUANGPU J | 1997 | FEBS Let ters1997，404，23： | 1 |
| 9 | Single nucleotide polymorphism associated with mature miR-125a alters the processing of pri-miRNA显示文摘 | Duan R Pak C H Jin P | 2007 | Human Molecular Genetics2007，16，9： | 1 |
| 10 | Monte Carlo simulation of large-scale problem of random rough surface scattering and applications to grazing incidence with the BMIA/canonical grid method 显示文摘 | Tsang L Chan C H Pak K | 1995 | IEEE Trans Antennas & Propaga1995，43，8： | 1 |
| 11 | AZF microdeletions of the Y chromosome and in vitro fe - ilization outcome 显示文摘 | Janet M Pak C Lucinda V | 2004 | Fertil Sterl2004，81，2： | 1 |
| 12 | Single nucleotide polymorphism associated with mature miR- 1 25a alters the processing of pd --miRNA显示文摘 | Duan R Pak C Jin P | 2007 | Hum Mol Genet2007，16，： | 1 |
| 13 | Induction of photoreceptor voltage noise in the dark in Drosophila mutant显示文摘 | Minke B Wu C Pak W L | | 0，，5530： | 1 |
| 14 | Hydrodynamic and heat transfer study of dispersed fluids with submicron metallic oxide particles 显示文摘 | PAK B C CHO Y I | 1998 | Experimental Heat Transfer1998，11，2： | 1 |
| 15 | Citrate and renal caiculi:an update 显示文摘 | Pak C Y C | 1994 | Mineral and elec- trolyte metabolism1994，20，6： | 1 |
| 16 | Charge-transfer- to-solvent-driven dissolution dynamics of 1-(H2 O) 2-5apon excitation: excited-state ab initio molecular dy- namics simulations显示文摘 | Kolaski M Lee HM Pak C | 2008 | J Am Chem Soc2008，0，： | 1 |
| 17 | Role of medical prevention显示文摘 | Pak CY Sakhaee K Fuller C | 1989 | J Uro l1989，141，32： | 1 |
| 18 | Serum endostatin levels are elevated in patients with soft tissue sarcoma显示文摘 | Feldman A L Pak H Yang J C etal | 2001 | Cancer2001，91，8： | 1 |
| 19 | Ordered Mesoporous Carbons (OMC) as Supports of Electroeatalysts for Direct Methanol Fuel Cells (DMFC) : Effect of Carbon Precursors of OMC on DMFC Performances 显示文摘 | Joo S H Pak C You D J | 2006 | Electrochim Acta2006，52，4： | 1 |
| 20 | Observation of an adiabatic shear band in AISI 4340 steel by highvoltage transmission electron microscopy 显示文摘 | Wittman C L Meyers M A Pak H R | 1990 | Metall Trans A1990，21，3： | 1 |
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