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| 1 | Natural polyphenols effects on protein aggregates in Alzheimer's and Parkinson's prion-like diseases显示文摘Alzheimer's and Parkinson's diseases are the most common neurodegenerative diseases. They are characterized by protein aggregates and so can be considered as prion-like disease. The major components of these deposits are amyloid peptide and tau for Alzheimer's disease, α-synuclein and synphilin-1 for Parkinson's disease. Drugs currently proposed to treat these pathologies do not prevent neurodegenerative processes and are mainly symptomatic therapies. Molecules inducing inhibition of aggregation or disaggregation of these proteins could have beneficial effects, especially if they have other beneficial effects for these diseases. Thus, several natural polyphenols, which have antioxidative, anti-inflammatory and neuroprotective properties, have been largely studied, for their effects on protein aggregates found in these diseases, notably in vitro. In this article, we propose to review the significant papers concerning the role of polyphenols on aggregation and disaggregation of amyloid peptide, tau, α-synuclein, synphilin-1, suggesting that these compounds could be useful in the treatments in Alzheimer's and Parkinson's diseases. | aline freyssin guylène page bernard fauconneau agnès rioux bilan | 2018 | Neural Regeneration Research2018，13，6： | 3 |
| 2 | Activated transcription factor nuclear factor-kappa B is present in the atherosclerotic lesion 显示文摘 | Brand K Page S Rogler G | 1996 | J Clin Invest1996，97，7： | 2 |
| 3 | Natural stilbenes effects in animal models of Alzheimer’s disease显示文摘Alzheimer’s disease is one of the most frequent neurodegenerative diseases.This pathology is characterized by protein aggregates,mainly constituted by amyloid peptide and tau,leading to neuronal death and cognitive impairments.Drugs currently proposed to treat this pathology do not prevent neurodegenerative processes and are mainly symptomatic therapies.However,stilbenes presenting multiple pharmacological effects could be good potential therapeutic candidates.The aim of this review is to gather the more significant papers among the broad literature on this topic,concerning the beneficial effects of stilbenes (resveratrol derivatives) in animal models of Alzheimer’s disease.Indeed,numerous studies focus on cellular models,but an in vivo approach remains of primary importance since in animals (mice or rats,generally),bioavailability and metabolism are taken into account,which is not the case in in vitro studies.Furthermore,examination of memory ability is feasible in animal models,which strengthens the relevance of a compound with a view to future therapy in humans.This paper is addressed to any researcher who needs to study untested natural stilbenes or who wants to experiment the most effective natural stilbenes in largest animals or in humans.This review shows that resveratrol,the reference polyphenol,is largely studied and seems to have interesting properties on amyloid plaques,and cognitive impairment.However,some resveratrol derivatives such as gnetin C,trans-piceid,or astringin have never been tested on animals.Furthermore,pterostilbene is of particular interest,by its improvement of cognitive disorders and its neuroprotective role.It could be relevant to evaluate this molecule in clinical trials. | Aline Freyssin Guylène Page Bernard Fauconneau Agnès Rioux Bilan | 2020 | Neural Regeneration Research2020，15，5： | 2 |
| 4 | The PageRank Citation Ranking:Bringing Order to the web显示文摘 | Brin S Page L Motwami R | 1998 | Stanford Digital Libraries Working Paper1998，，6： | 1 |
| 5 | Towards sustainable tourism planning in New Zealand: Monitoring local government planning under the Resource Management Act 显示文摘 | Connell J Page S J Bentley T ( 2009 ) | 2009 | Tourism Management2009，，： | 1 |
| 6 | The Choice of Invoicing Currency in Merchandise Trade显示文摘 | Bergsten Page S | 1981 | National Institute Economic Review1981，，1： | 1 |
| 7 | Activated transcription factor nuclear factor kappa B is present in the atherosclerotic lesion J2 显示文摘 | Brand K Page S Rogler C | 1996 | J Clin Invest1996，97，7： | 1 |
| 8 | Tympanometric screening in elementary school children显示文摘 | Page A Kramer S Novak J | 1995 | Audiology1995，34，： | 1 |
| 9 | Agent-based and analytical mode|ing to evaluate the effectiveness of green- belts 显示文摘 | BROWN D G PAGE S E RIOLO R | 2003 | Environmental Modeling & Software2003，19，12： | 1 |
| 10 | The molecular analysis of leaf senescence-A genomics approach显示文摘 | BUCHANAN-WOLLASTON V EARL S HARRISON E MATHAS E NAVABPOUR S PAGE T PINK D | 2003 | Plant Biotechnology Journal2003，1，： | 1 |
| 11 | Differential effects of lipopolysaccharide and tumor necrosis factor on monocytic IκB kinase signalsome activation and IκB proteolysis显示文摘 | Fischer C Page S Weber M | | 0，，： | 1 |
| 12 | Exploring the spatial patterns of car-based tourist travel in Loch Lomond and Trossachs National Park, Scotland 显示文摘 | Connell J Page S J | 2008 | Tourism Management2008，29，3： | 1 |
| 13 | Diagnostic performance of the(1->3)-beta-D-Glucan assay for invasive fungal disease显示文摘 | Koo S Bryar JM Page JH | 2009 | Clinical Infectious Diseases2009，49，11： | 1 |
| 14 | Efficacy of modified constraint in duced movement therapy in chronic stroke: a single blinded random ized controlled trial显示文摘 | Page SJ Sisto S Levine P | 2004 | Arch Phys Med Rehabil2004，85，： | 1 |
| 15 | The anatomy of a large-scale hypertextual Web search engine显示文摘 | Brin S Page L | 1998 | Intemational Journal of Approximate Reasoning1998，156，4： | 1 |
| 16 | Hydrocarbon-free resonance transition 795 nm rubidium laser显示文摘 | Wu S S Q Soules T F Page R H | 2007 | Opt Lett2007，32，16： | 1 |
| 17 | Anatomic localization of immature and mature dentritic cells in an ectopic lymphoid organ: correlation with selective chemokine expression in rheumatoid synovium显示文摘 | Page G Lebecque S Miossec P | 2002 | J Immunol2002，168，10： | 1 |
| 18 | Activated Transcription Factor Nuclear Factor-kappaB is Present in the Atnerosclerosis Lesion显示文摘 | Brad K Pages S Rogler G | 1996 | Clin Invest1996，97，7： | 1 |
| 19 | Efficacy of modified constraint - induced movement therapy in chronic stroke : a singe - Blinded controlled trial显示文摘 | Page SJ Sisto S Levine P | 2004 | Arch Phys Med Rehahil2004，85，1： | 1 |
| 20 | Exploring the spatial patterns of car-based tourist travel in Loch Lomond and Trossachs National Park, Scotland 显示文摘 | Connell J Page S J | 2008 | Tourism Management2008，29，3： | 1 |
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