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| 1 | Bitter melon: a panacea for inflammation and cancer显示文摘Nature is a rich source of medicinal plants and their products that are useful for treatment of various diseases and disorders. Momordica charantia, commonly known as bitter melon or bitter gourd, is one of such plants known for its biological activities used in traditional system of medicines. This plant is cultivated in all over the world, including tropical areas of Asia, Amazon, east Africa, and the Caribbean and used as a vegetable as well as folk medicine. All parts of the plant, including the fruit, are commonly consumed and cooked with different vegetables, stir-fried, stuffed or used in small quantities in soups or beans to give a slightly bitter flavor and taste. The plant is reported to possess anti-oxidant, anti-inflammatory, anti-cancer, anti-diabetic, anti-bacterial, anti-obesity, and immunomodulatory activities. The plant extract inhibits cancer cell growth by inducing apoptosis, cell cycle arrest, autophagy and inhibiting cancer stem cells. The plant is rich in bioactive chemical constituents like cucurbitane type triterpenoids, triterpene glycosides, phenolic acids, flavonoids, essential oils, saponins, fatty acids, and proteins. Some of the isolated compounds(Kuguacin J, Karaviloside XI, Kuguaglycoside C, Momordicoside Q-U, Charantin, α-eleostearic acid) and proteins(α-Momorcharin, RNase MC2, MAP30) possess potent biological activity. In the present review, we are summarizing the anti-oxidant, anti-inflammatory, and anti-cancer activities of Momordica charantia along with a short account of important chemical constituents, providing a basis for establishing detail biological activities of the plant and developing novel drug molecules based on the active chemical constituents. | Prasad R. Dandawate Dharmalingam Subramaniam Subhash B. Padhye Shrikant Anant | 2016 | Chinese Journal of Natural Medicines2016，14，2： | 14 |
| 2 | Potential therapeutics specific to c-MET/RON receptor tyrosine kinases for molecular targeting in cancer therapy显示文摘遇见 c 的 proto-oncogenes 和 RON 的产品属于受体酷氨酸 kinases 的一个亚科显著地作出贡献到 tumorigenic 前进。在主要肿瘤,改变了调整被房间移植和矩阵侵略描绘的侵略生长的 c-MET/RON 表达式 transduces 信号。这些病原的特征为在癌症治疗指向 c-MET/RON 提供基础。在最后十年,各种各样的途径被调查了压制 c-MET/RON-transduced oncogenesis。在开发的治疗学之中, monoclonal 抗体(mAbs ) 和小分子的禁止者(SMI ) 作为有希望的候选人出现了。这些治疗学的候选人的机制是为幸存的 c-MET/RON 信号上的肿瘤相关性的混乱。对 hepatocyte 生长因素(AMG102 ) 特定、遇见 c 的 mAbs (MetMAb ) 是人性化并且能堵住遇见 c 的发信号,在异种皮移植在肿瘤生长的 vitro 和抑制导致肿瘤房间增长的抑制当模特儿。mAb AMG102 抵销 hepatocyte 生长因素并且在 vivo 提高各种各样的 chemotherapeutics 的 cytotoxicity 到肿瘤。AMG102 当前在为有先进稳固的肿瘤的病人的阶段 II 临床的试用。IMC-41A40 和 Zt/f2 是 RON 特定的 mAbs 那下面调整 RON 表情并且禁止导致 ligand 的 phosphorylation。两 mAbs 在老鼠禁止肿瘤生长由冒号和胰腺的癌症细胞调停了。对特定的 SMI 遇见 c (ARQ107 和 PF-02341066 ) 在临床的试用的各种各样的阶段。治疗学的功效也与象化合物那样的双禁止者被观察了我,它对 c-MET/RON 特定。然而,一个潜在的问题是到这些禁止者的获得的抵抗的出现。清楚地, c-MET/RON 治疗学的开发为以后与癌症作斗争提供机会和挑战。 | Ming-Hai WANG Snehal S PADHYE Sunny GUIN Qi MA Yong-qing ZHOU | 2010 | Acta Pharmacologica Sinica2010，31，9： | 10 |
| 3 | The role of genistein and synthetic derivatives of isoflavane in cancer prevention and therapy 显示文摘 | Sarkar FH Adsule S Padhye S | 2006 | Med Chem2006，6，4： | 1 |
| 4 | Modeling TCP Reno performance:A simple model and its empirical validation显示文摘 | Padhye J firoiu V and Towsley D F | 2000 | IEEE/ACM Transactions on Networking2000，8，2： | 1 |
| 5 | Modeling TCP throughput: A simple model and its empirical validation 显示文摘 | Padhye Jetal | 1998 | Computer Communication Review1998，28，4： | 1 |
| 6 | Impact of interference on multi-hop wireless network performance 显示文摘 | Jain K Padhye J Padmanabhan V N | 2005 | Wireless Networks2005，11，4： | 1 |
| 7 | Routing in multi - radio, multi - hop wireless mesh networks 显示文摘 | R Draves J Padhye B Zill | 2004 | Philadelphia PA USA: International Conference on Mobile Computing and Networking2004，2004，： | 1 |
| 8 | Modeling TCP throughput: A simple model and its empirical validation显示文摘 | Padhye J | 1998 | Proc ACM SIGCOMM1998，28，4： | 1 |
| 9 | 显示文摘 | Padhye U | 2003 | Med Hypotheses2003，61，： | 1 |
| 10 | A new medium for the presumptive identification of dermatophytes 显示文摘 | Salkin IF Padhye AA Kemna ME | 1997 | J Clin Microbiol1997，35，10： | 1 |
| 11 | Future prospects of systemic host modulatory agents in periodontal therapy显示文摘 | Gokhale SR Padhye AM | | 0，，09： | 1 |
| 12 | Comparative evaluation of chemiluminescent DNA probe assays and exoantigen tests for rapid identification of Blastomyces dermatitidis and Coccidioides immitis显示文摘 | Padhye AA Smith G Standard PG | 1994 | J Clin Microbiol1994，32，4： | 1 |
| 13 | Hydrothermal synthesis,crystal structure,spectroscopy,electrochemistry and antimycobacterial evaluation of the copper (Ⅱ) ciprofloxacin complex:· 6H2O显示文摘 | Saha D K Padhye S Anon C E | 2002 | Inorganic Chemistry Communications2002，5，： | 1 |
| 14 | Modeling TCP Reno performance:a simple model and its empirical validation显示文摘 | Padhye J Firoiu V Towsley D | 2000 | IEEE ACM Transactions on Networking2000，8，2： | 1 |
| 15 | Extraction and characterization of rice proteins显示文摘 | Padhye V W Salunkhe D K | 1979 | Cereal Chem1979，56，： | 1 |
| 16 | Modeling TCP Throughput: A Simple Model and Its Empirical Vilidation显示文摘 | Padhye J Towsley D Firoiu V | 1998 | ACM SIGCOMM Computer Communication Review1998，28，4： | 1 |
| 17 | Gemcitabine sensitiv-ity can be induced in pancreatic cancer cells through modulation of miR-200 and miR-21 expression by curcumin or its analogue CDF显示文摘 | Ali S Ahmad A Banerjee S Padhye S | | 0，，35： | 1 |
| 18 | Modeling TCP reno performance: a simple model and its empirical Validation显示文摘 | Padhye J Firoiu V Towsley D | 2000 | IEEE/ACM Transactions on networking2000，8，2： | 1 |
| 19 | Modeling TCP reno performance: A simple model and its empiricalvalidation显示文摘 | Padhye J Firoiu V Towsley D | 2000 | IEEE/ACM Transactions on Networking2000，8，2： | 1 |
| 20 | Subcutaneous phae- ohyphomycosis caused by Exophiala spinifera显示文摘 | Padhye AA Kaplan W Neuman MA | 1984 | Sabouraudia1984，22，6： | 1 |
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