|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Antibacterial approaches in tissue engineering using metal ions and nanoparticles:From mechanisms to applications显示文摘Bacterial infection of implanted scaffolds may have fatal consequences and,in combination with the emergence of multidrug bacterial resistance,the development of advanced antibacterial biomaterials and constructs is of great interest.Since decades ago,metals and their ions had been used to minimize bacterial infection risk and,more recently,metal-based nanomaterials,with improved antimicrobial properties,have been advocated as a novel and tunable alternative.A comprehensive review is provided on how metal ions and ion nanoparticles have the potential to decrease or eliminate unwanted bacteria.Antibacterial mechanisms such as oxidative stress induction,ion release and disruption of biomolecules are currently well accepted.However,the exact antimicrobial mechanisms of the discussed metal compounds remain poorly understood.The combination of different metal ions and surface decorations of nanoparticles will lead to synergistic effects and improved microbial killing,and allow to mitigate potential side effects to the host.Starting with a general overview of antibacterial mechanisms,we subsequently focus on specific metal ions such as silver,zinc,copper,iron and gold,and outline their distinct modes of action.Finally,we discuss the use of these metal ions and nanoparticles in tissue engineering to prevent implant failure. | Maria Godoy-Gallardo Ulrich Eckhard Luis M.Delgado Yolanda J.D.de Roo Puente Mireia Hoyos-Nogués F.Javier Gil Roman A.Perez | 2021 | Bioactive Materials2021，6，12： | 14 |
| 2 | Plasma betatrophin levels in patients with liver cirrhosis显示文摘AIM: To investigate the plasma levels of betatrophin in patients with cirrhosis.METHODS: Forty patients diagnosed at the clinic with liver cirrhosis according to biological, ultrasonographic,or histological criteria were included.The severity of cirrhosis was classified according to Pugh's modification of Child's classification and MELD score. Insulin resistance(IR) was assessed by the Homeostasis Model Assessment. A total of 20 patients showed a MELD score higher than 14. The control group consisted in 15 sex-and aged-matched subjects.Fasting blood samples were obtained for subsequent analysis. Serum insulin was determined by Liaison automated immune chemiluminiscence assay(DiaSorin S.p.A.) using a sandwich assay. The sensitivity of the assay was 0.2 μU/mL. The intra and interassay variation coefficients were < 4% and < 10%,respectively. The normal values were between 2 and17 μU/mL. Human active betatrophin was analyzed by specific quantitative sandwich ELISA(Aviscera Bioscience). The sensitivity of the assay was 0.4 ng/mL, and the intra and interassay reproducibility were< 6% and < 10%, respectively.RESULTS: Plasma betatrophin levels were significantly increased in patients with cirrhosis compared with those in healthy subjects(P = 0.0001). Betatrophin levels were also associated with disease severity, being higher in Child-Pugh C patients compared to Child-Pugh B(P< 0.0005) and in patients who displayed a MELD score higher than 14 points compared to patients with lower punctuation(P = 0.01). In addition, we found a positive correlation between plasma betatrophin levels and the severity of cirrhosis according to Child-Pugh classification(r = 0.53; P < 0.01) or MELD score(r = 0.45; P <0.01). In the overall cohort, a moderate correlation between serum betatrophin and plasmatic bilirrubin(r= 0.39; P < 0.01) has been observed, as well as an inverse correlation between betatrophin and albumin(r =-0.41; P < 0.01) or prothrombin time(r =-0.44;P <0.01). Moreover, insulin resistance was observed in82.5% of the cirrhotic patients. In this group of patients,betatrophin levels were significantly higher than those in the group of patients without IR(P < 0.05).CONCLUSION: Plasma betatrophin is increased in patients with cirrhosis. This increase is related to the severity of cirrhosis, as well as with the emergence of insulin resistance. | Maria Teresa Arias-Loste Maria Teresa García-Unzueta Susana Llerena Paula Iruzubieta Angela Puente Joaquín Cabezas Carmen Alonso Antonio Cuadrado José Antonio Amado Javier Crespo Emilio Fábrega | 2015 | World Journal of Gastroenterology2015，21，37： | 9 |
| 3 | Speckle tracking echocardiography to assess regional ventricular function in patients with apical hypertrophic cardiomyopathy显示文摘AIM To explore regional systolic strain of midwall and endocardial segments using speckle tracking echocardiography in patients with apical hypertrophic cardiomyopathy(HCM).METHODS We prospectively assessed 20 patients(mean age 53 ± 16 years,range:18-81 years,10 were male),with apical HCM. We measured global longitudinal peak systolic strain(GLPSS) in the midwall and endocardium of the left ventricle. RESULTS The diastolic thickness of the 4 apical segments was 16.25 ± 2.75 mm. All patients had a normal global systolicfunction with a fractional shortening of 50% ± 8%. In spite of supernormal left ventricular(LV) systolic function,midwall GLPSS was decreased in all patients,more in the apical(-7.3% ±-8.8%) than in basal segments(-15.5% ±-6.93%),while endocardial GLPPS was significantly greater and reached normal values(apical:-22.8% ±-7.8%,basal:-17.9% ±-7.5%). CONCLUSION This study shows that two-dimensional strain was decreased mainly confined to the mesocardium,while endocardium myocardial deformation was preserved in HCM and allowed to identify subclinical LV dysfunction. This transmural heterogeneity in systolic strain had not been previously described in HCM and could be explained by the distribution of myofibrillar disarray in deep myocardial areas. The clinical application of this novel finding may help further understanding of the pathophysiology of HCM. | María Cristina Saccheri Tomás Francisco Cianciulli Luis Alberto Morita Ricardo JoséMéndez Martín Alejandro Beck Juan Enrique Guerra Alberto Cozzarin Luciana Jimena Puente Lorena Romina Balletti Jorge Alberto Lax | 2017 | World Journal of Cardiology2017，9，4： | 7 |
| 4 | Impact of an acute hemodynamic response-guided protocol for primary prophylaxis of variceal bleeding显示文摘AIM To evaluate the long-term outcome of an acute hemodynamic response-guided protocol in which acute responders to intravenous propranolol received traditional nonselective beta-blockers(NSBBs) and acute nonresponders received carvedilol.METHODS Retrospective review of a protocol for primary prophylaxis of variceal bleeding guided by the acute hemodynamic response to intravenous propranolol. Fifty-two acute responders treated with traditional NSBB(i.e. propranolol or nadolol) were compared with 24 acute nonresponders receiving carvedilol. A second hemodynamic study was performed in 27 and 13 patients, respectively. The primary endpoint was development of first or further decompensation. Secondary endpoints included death from any cause, association between acute and chronic hemodynamic response, and baseline clinical and laboratory variables related to the acute hemodynamic response.RESULTS Acute responders and acute nonresponders presented similar 1, 2, and 3-year probabilities of first decompensation(NSBB: 0%, 13.7%, 26.1% vs carvedilol: 0%, 20%, 20%, P = 0.968) or further decompensation(21.2%, 26.1%, 40.9% vs 21.2%, 50.0%, 50.0%, P = 0.525). A previous episode of hepatic encephalopathy was the only independent predictor of decompensation [hazard ratio(95% confidence interval): 8.03(2.76-23.37)]. Mortality rates were similar in acute responders and acute nonresponders with compensated(P = 0.428) or decompensated cirrhosis(P = 0.429). No clinical, laboratory, endoscopic or hemodynamic parameter predicted the acute hemodynamic response. In patients receiving traditional NSBB, the acute and chronic changes of hepatic venous pressure gradient were correlated(r = 0.59, P = 0.001). Up to 69.2% of acute nonresponders gained chronic response with carvedilol.CONCLUSION Early identification and treatment with carvedilol of acute nonresponders to intravenous propranolol improves the clinical outcome of this high-risk group of patients, probably due to its greater effects for reducing portal pressure. | José Ignacio Fortea ángela Puente Patricia Ruiz Iranzu Ezcurra Javier Vaquero Antonio Cuadrado María Teresa Arias-Loste Joaquín Cabezas Susana Llerena Paula Iruzubieta Carlos Rodríguez-Lope Patricia Huelin Fernando Casafont Emilio Fábrega Javier Crespo | 2018 | World Journal of Clinical Cases2018，6，13： | 6 |
| 5 | Previous antiplatelet therapy is anindependent predictor of 30–day mortalityafter spontaneous supratentorialintracerebral hemorrhage显示文摘 | Jaume Roquer Ana Rodríguez Campello Meritxell Gomis Angel Ois Victor Puente Elvira Munteis | 2005 | Journal of Neurology2005，，4： | 2 |
| 6 | Radiological anatomy of the biliary tract: Variations and congenital abnormalities显示文摘 | Sergio G. Puente M.D. F.A.C.S. Guillermo C. Bannura M.D | 1983 | World Journal of Surgery1983，，2： | 2 |
| 7 | Sorafenib for non-selected patient population with advanced hepatocellular carcinoma: efficacy and safety data according to liver function显示文摘 | Jon Zugazagoitia Aránzazu Manzano Javier Sastre Jose María Ladero Javier Puente Eduardo Díaz-Rubio | 2013 | Clinical and Translational Oncology2013，，2： | 2 |
| 8 | Wind effects on the migration routes of trans-Saharan soaring raptors: geographical, seasonal, and interspecific variation显示文摘 | Javier VIDAL-MATEO Ugo MELLONE Pascual LOPEZ-LOPEZ Javier De LA PUENTE clara GARCIA-RIPOLLES Ana BERMEJO Vicente URIOS | 2016 | Current Zoology2016，62，2： | 2 |
| 9 | Prevalence of anxiety and depression among chronic bronchitis patients and the associated factors 显示文摘 | Miguel D J Hernandez BV Puente ML | 2011 | Respirology2011，16，7： | 1 |
| 10 | Human autophagins, a family of eysteine pmteinases potentially implicated in cell degradation by autophagy显示文摘 | Marifio G Uria JA Puente XS | 2003 | J Biol Chem2003，278，6： | 1 |
| 11 | Sodium hypochlorite chemical burn in an endodontists eye during canal treatment using operating microscope显示文摘 | Regalado Farreras DC Carlos Puente CG Estrela C | 2014 | J Endod2014，40，8： | 1 |
| 12 | Do the pelvic lymph nodes predict the parametrial status in cervical cancer stages I B-- II A? 显示文摘 | Puente R Guzman S Israel E | 2004 | Int J Gynecol Cancer2004，14，： | 1 |
| 13 | Compositional and structural changes during aerial oxidation of coal and their relations with technological properties 显示文摘 | Iglesias M J de la Puente G Fuente E | 1998 | Vibrational Spectroscopy1998，17，1： | 1 |
| 14 | Identification of candidate regulatars of embryonic stem cell differentiation by comparative phosphoprotain-affinity profiling显示文摘 | Puente LG Borris DJ Carriere JF | 2005 | Mol Cell Proteomics2005，，： | 1 |
| 15 | Variations in sensitivity after sectioning the intercostobrachial nerve显示文摘 | Paredes JP Puente JL Potel J | 1990 | Am J Surg1990，160，5： | 1 |
| 16 | Antiproliferative effect of somatostatin and analogs显示文摘 | Bousquet C Puente E Buscail L | 2001 | Chemotherapy2001，47，2： | 1 |
| 17 | Circulating tumor cells in colorectal cancer:correlation with clinical and pathological variables显示文摘 | Sastre J Maestro ML Puente J | 2008 | Ann Oncol2008，19，5： | 1 |
| 18 | Identification of a differentially expressed mRNA in axenic Leishmania panamensis amastigotes显示文摘 | Gutierrez JA Puentes F Moreno A | 2001 | Memorias do Institute Oswaldo Cruz2001，96，6： | 1 |
| 19 | From cyberfeminism to technofeminism:From an essentialist perspective to social cyberfeminism in certain feminist practices in Spain显示文摘 | Sonia Núuez Puente | | 0，，06： | 1 |
| 20 | Previous antiplatelet therapy is an independent predictor of 30–day mortality after spontaneous supratentorial intracerebral hemorrhage显示文摘 | Jaume Roquer MD PhD Ana Rodríguez Campello MD Meritxell Gomis MD Angel Ois MD Victor Puente MD Elvira Munteis MD | 2005 | Journal of Neurology2005，，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员