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| 1 | 血管性认知障碍的诊断标准:国际血管性行为与认知障碍学会的申明显示文摘长期以来,脑血管病(CVD)就被认为是认知损害的一个重要原因,但是有关脑血管病后认知障碍的概念化却有着一段多变的历史。'动脉变硬'或脑的动脉粥样硬化是'老化'的原因,是存在已久的观点,在20世纪60年代受到了来自英格兰纽卡斯尔的神经病理学研究的质疑。这些研究表明,血管性痴呆(vascular dementia,Va D)与超过一定程度的多发性脑梗死有关。 | 徐岩 郭起浩 Sachdev P Kalaria R O'Brien J Skoog I Alladi S Black SE Blacker D Blazer DG Chen C Chui H Ganguli M Jellinger K Jeste DV Pasquier F Paulsen J Prins N Rockwood K Roman G Scheltens P | 2014 | 神经病学与神经康复学杂志2014，11，3： | 19 |
| 2 | Patterns of genomic and phenomic diversity in wine and table grapes显示文摘Grapes are one of the most economically and culturally important crops worldwide,and they have been bred for both winemaking and fresh consumption.Here we evaluate patterns of diversity across 33 phenotypes collected over a 17-year period from 580 table and wine grape accessions that belong to one of the world’s largest grape gene banks,the grape germplasm collection of the United States Department of Agriculture.We find that phenological events throughout the growing season are correlated,and quantify the marked difference in size between table and wine grapes.By pairing publicly available historical phenotype data with genome-wide polymorphism data,we identify large effect loci controlling traits that have been targeted during domestication and breeding,including hermaphroditism,lighter skin pigmentation and muscat aroma.Breeding for larger berries in table grapes was traditionally concentrated in geographic regions where Islam predominates and alcohol was prohibited,whereas wine grapes retained the ancestral smaller size that is more desirable for winemaking in predominantly Christian regions.We uncover a novel locus with a suggestive association with berry size that harbors a signature of positive selection for larger berries.Our results suggest that religious rules concerning alcohol consumption have had a marked impact on patterns of phenomic and genomic diversity in grapes. | ZoëMigicovsky Jason Sawler Kyle M Gardner Mallikarjuna K Aradhya Bernard H Prins Heidi R Schwaninger Carlos D Bustamante Edward S Buckler Gan-Yuan Zhong Patrick J Brown Sean Myles | 2017 | Horticulture Research2017，4，1： | 3 |
| 3 | Single-port laparoscopic cholecystectomy vs standard laparoscopic cholecystectomy:A non-randomized,agematched single center trial显示文摘AIM: To compare the safety of single-port laparoscopic cholecystectomies with standard four-port cholecystectomies.METHODS: Between January 2011 and December 2012 datas were gathered from 100 consecutive patients who received a single-port cholecystectomy. Patient baseline characteristics of all 100 single-port cholecystectomies were collected(body mass index, age, etc.) in a database. This group was compared with 100 age-matched patients who underwent a conventional laparoscopic cholecystectomy in the same period. Retrospectively, per- and postoperative data were added. The two groups were compared to each other using independent t-tests and χ2-tests, P values below 0.05 were considered significantly different.RESULTS: No differences were found between both groups regarding baseline characteristics. Operating time was significantly shorter in the total single-port group(42 min vs 62 min, P < 0.05); in procedures performed by surgeons the same trend was seen(45 min vs 59 min, P < 0.05). Peroperative complications between both groups were equal(3 in the single-port group vs 5 in the multiport group; P = 0.42). Although not significant less postoperative complications were seen in the single-port group compared with the multiport group(3 vs 9; P = 0.07). No statistically significant differences were found between both groupswith regard to length of hospital stay, readmissions and mortality. CONCLUSION: Single-port laparoscopic cholecystectomy has the potential to be a safe technique with a low complication rate, short in-hospital stay and comparable operating time. Single-port cholecystectomy provides the patient an almost non-visible scar while preserving optimal quality of surgery. Further prospective studies are needed to prove the safety of the single-port technique. | Yoen TK van der Linden Koop Bosscha Hubert A Prins Daniel J Lips | 2015 | World Journal of Gastrointestinal Surgery2015，7，8： | 2 |
| 4 | Parameters of rumen fermentation in a continuously fed sheep: evidence of a microbial rumina-tion pool 显示文摘 | Hungate R E Reichl J Prins R | 1971 | Appl Microbiol Biot1971，22，6： | 1 |
| 5 | Progression of cerebral small vessel disease in relation to risk factors and cognitive consequences: Rotterdam Scan study显示文摘 | Van DE J Prins ND Vrooman HA | 2008 | Stroke2008，39，10： | 1 |
| 6 | Systemic tumor necrosis factor-alpha decreases brain stimulation reward and increases metabolites of serotonin and dopamine in the nucleus accumbens of mice显示文摘 | van Heesch F Prins J Korte-Bouws GA | 2013 | Behav Brain Res2013，253，： | 1 |
| 7 | Application of DDRT-PCR to the analysis of differential gene expression in a plant-fungus interaction显示文摘 | Prins T van Kan J A | 1996 | Plant Molecular Biology1996，32，5： | 1 |
| 8 | A 300-kyr record of aridity and wind strength in southwestern African : inference from grain-size distributions of sediments on Walvis Ridge, Southeast Atlantic 显示文摘 | Stuut J B Prins M A Schneider P R | 2002 | Marine Geology2002，180，： | 1 |
| 9 | Cerebral white matter lesions and the risk of dementia显示文摘 | Prins N D van Dijk E J den Heijer T | | 0，，10： | 1 |
| 10 | Determinants of exercise capacity in patients with type 2 diabetes 显示文摘 | Fang Z Y Sharman J Prins J B | 2005 | DiabetesCare2005，28，： | 1 |
| 11 | Carbon-supported sulfide catalysts显示文摘 | DUCHET J C Van OERS E M De BEER V H J PRINS R | 1983 | J Catal1983，80，2： | 1 |
| 12 | MAS NMR, TPR and TEM studies of the interaction of NiMo with alumina and silica-alumina supports显示文摘 | QU L ZHANG W KOOYMAN P J PRINS R | 2003 | J Catal2003，215，1： | 1 |
| 13 | Particle segregation in fluidized binary mixtures显示文摘 | Hoffmann A C Janssen M L P B J Prins | 1993 | Chem Eng Sci1993，48，9： | 1 |
| 14 | Matrix metalloproteinase inhibition a|ter functional and structural correlates of deaffer- entation-induced sprouting in the dentate gyms显示文摘 | Reeves TM Prins ML Zhu J | 2003 | J Neuro- sci2003，23，10： | 1 |
| 15 | Immunologic marker analysis of normal and malignant histiocyte 显示文摘 | Roholl PJ Kleyne J Prins ME | 1988 | Am J Clin Pathol1988，89，2： | 1 |
| 16 | AFLP and STS tagging of Lr19,a gene conferring resistance to leaf rust in wheat显示文摘 | PRINS R GROENEWALD J Z MARAIS G F | | 0，，04： | 1 |
| 17 | MAS NMR, TPR, and TEM studies of the interaction of NiMo with alumina and silica-alumina supports显示文摘 | QU L ZHANG W KOOYMAN P J PRINS R | 2003 | J Catal2003，215，1： | 1 |
| 18 | Use of imatinib in a patient with cutaneous vasculopathy in the context of von Recklinghausen disease/ neurofibromatosis 显示文摘 | KHELIFA I SAURAT J H PRINS C | 2015 | Br J Derrnatol2015，172，1： | 1 |
| 19 | Modelling of flash pyrolysis of a single particle显示文摘 | Janse A M C Westerhout R W J Prins W | 2000 | Chemical Engineering and Processing2000，39，3： | 1 |
| 20 | A critical review of the relationship between impaired fibrinolysis and myocardial farction 显示文摘 | Prins Mh Hirsh J | 1991 | Am Heart J1991，122，： | 1 |
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