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| 1 | Obesity-induced sperm DNA methylation changes at satellite repeats are reprogrammed in rat offspring显示文摘现在有充分证据,对在使肥沃的后代显型的父亲的贡献多于公平 DNA。然而,这 nongenetic 继承的身份和机制糟糕被理解。在这个研究区域的更重要的问题之一是:在精子 DNA methylation 的变化为后代有 phenotypic 后果吗?我们以前报导了肥胖的雄的老鼠的后代与控制相比改变了葡萄糖新陈代谢并且这效果通过 nongenetic 工具被继承。这里,我们用一样的协议在一个新队描述调查进精子 DNA methylation。在高脂肪的节食的雄的老鼠是 30% 比喂控制的男性重在交配的时候(16-19 星期旧, n = 14/14 ) 。一小(0.25%) 在全部的 5-methyl-2 ’ 增加; -deoxycytidine 被液体层析双人脚踏车团 spectrometry 在肥胖的老鼠精子检测。那 retrotransposon DNA methylation 在精子说的有定序的充实蛋白质的染色体(MBD-Seq ) 和 pyrosequencing 揭示了的 methyl-CpG 绑定领域的染色体的重复部分的检查没被肥胖,而是 methylation 在整个染色体在卫星重复影响被增加。然而,从男 27-week-old 后代从的肌肉,肝,和精子的检查肥胖并且控制父亲(从 8 生的 n = 的两个组) 表明正常 DNA methylation 层次在后代开发期间被恢复。而且,没有变化在肥胖的老鼠精子在三个 genomic 印记被发现。我们的调查结果为 transgenerational epigenetic reprogramming 有含意。他们建议 postfertilization 机制为使导致 environmentally 的 DNA methylation 在精子房间改变的一些正常化存在。 | Neil A Youngson Virginie Lecomte Christopher A Maloney Preston Leung Jia Liu Luke B Hesson Fabio Luciani Lutz Krause Margaret J Morris | 2016 | Asian Journal of Andrology2016，18，6： | 3 |
| 2 | The Selective Solvent Extraction of Cadmium By Mixtures of Carboxylic Acids and Trialkylphosphine Sulphides 显示文摘 | Preston J S | 1994 | Hydrometallurgy1994，，36： | 2 |
| 3 | Laser Induced Periodic Surface Damage and Radiation Remnants 显示文摘 | YOUNG J F SIPE J E PRESTON J S | 1982 | Appl Phys Lett1982，41，： | 1 |
| 4 | Pneumocystis murina infection and cigarette smoke exposure interact to cause increased organism burden,development of airspace enlargement,and pulmonary Inflammation in mice显示文摘 | Christensen P J Preston A M Ling T | 2008 | Infect Immun2008，76，8： | 1 |
| 5 | Discrete Equilibrium Price Dispersion显示文摘 | CARLSON J PRESTON M | 1983 | Journal of Political Economy1983，，： | 1 |
| 6 | Parentage determination of Kuruma shrimp Penaeus (Marsupenaeus) japonicus using microsatellite markers (Bate)显示文摘 | DENA R J NIGEL P PRESTON P J | 2004 | Aquaculture2004，235，： | 1 |
| 7 | Molecular analysis of bacterial pathogens in otitis media with effusion显示文摘 | POST J C PRESTON R A JEROME J A | 1995 | JAMA1995，273，： | 1 |
| 8 | Factors affecting the printing strength of kaolin-based paper coatings 显示文摘 | Husband J C Preston J S Gate L F | 2008 | TAGA Journal2008，，： | 1 |
| 9 | Total knee arthroplasty after high tibial osteotomy:no differences between medial and lateral osteotomy approaches显示文摘 | Preston S Howard J Naudie D | 2014 | Clin Orthop Relat Res2014，472，1： | 1 |
| 10 | The Ex-ante and Ex-post Economic and Social Impacts of the Introduction of High-speed Trains in South East England显示文摘 | Preston J Wall G | 2008 | Planning Practice and Research2008，23，3： | 1 |
| 11 | Separation of Nickel and Calci- um by Solvent Extraction Using Mixtures of Carboxylic Acids and Alkylpyridines显示文摘 | Preston J S Du Preez A C | 2000 | Hydrometallurgy2000，58，3： | 1 |
| 12 | Origin of the fastphotoresponse of epitaxial YBa2Cu3O7-8 thin film显示文摘 | Hegmann F A Preston J S | 1993 | Physical Review B1993，48，21： | 1 |
| 13 | Effect of diet form and enzyme supplementation on growth, efficiency and energy utilization of wheat - based diets for broilers 显示文摘 | Preston C M Mccracken K J McaUister A | 2000 | British Poultry Science2000，41，： | 1 |
| 14 | Inoprint lithography with 25-nanometer resolation显示文摘 | Stephen Y C Pete R K Preston J R | 1996 | Science1996，272，5： | 1 |
| 15 | Size-fractionated primary production and nitrogen uptake during a North Atlantic phytoplankton bloom: implications for carbon export estimates 显示文摘 | BURY S J BOYD P W PRESTON T | 2001 | Deep-Sea Res2001，48，3： | 1 |
| 16 | Finite element modeling of tungsten inert gas welding of aluminium alloy 2024显示文摘 | Preston R V Shercliff H R Withers P J | 2003 | Science and Technology of Welding and Jointing2003，8，1： | 1 |
| 17 | Small and medium-sized enterprises, technology, and globalization : Introduction to a special issue on small and medium-sized enterprises in the global economy 显示文摘 | Acs Z J Preston L | 1997 | Small Business Economics1997，9，1： | 1 |
| 18 | Improved enzy- matic method to measure processing effects and starch availability in sorghum grain显示文摘 | Xiong Y Bartle S J Preston R L | 1990 | Journal of an- imal science1990，68，11： | 1 |
| 19 | 60 20 emission the unequal distribution of greenhouse gas emissions from personal, non business travel in the UK显示文摘 | Brand C Preston J M | 2010 | Transport Policy2010，17，1： | 1 |
| 20 | Nitrogen Budget and Effluent Nitrogen Components at an Intensive Shrimp Farm 显示文摘 | Jackson C Preston N Thompson P J | 2003 | Aquaculture2003，218，14： | 1 |
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