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| 1 | 2型糖尿病患者个体化血糖控制目标和药物治疗显示文摘'有效管理糖尿病全球合作组织'(下称'糖尿病全球合作组织')成立的宗旨是为临床提供实用指南以改善糖尿病患者的预后,制定并修改相关策略以改善T2DM患者血糖控制情况。糖尿病全球合作组织提倡对糖尿病患者实行个体化治疗方案,明确需要特殊考虑T2DM患者亚组人群。这篇文章基于此前发表的文献,扩大了实用指南的范围,包括有并发症的新诊断T2DM患者和妊娠期糖尿病(GDM)患者。良好血糖控制是T2DM管理的基石,在预防或延缓糖尿病并发症的发生、发展过程中发挥重要作用。个体化治疗目标和安全及时的血糖达标治疗方案至关重要。另外,还需制定更全面的护理计划以降低心血管风险和改善患者预后。 | 张晓梅 纪立农 Bailey CJ Aschner P Stefano Del Prato LaSalle J JI Li-nong Matthaei S | 2014 | 中国糖尿病杂志2014，22，10： | 16 |
| 2 | Hemozoin triggers tumor necrosis factor alpha-mediated release of lysozyme by human adherent monocytes:new evidences on leukocyte degranulation in P.falciparum malaria显示文摘Objective:Avidly phagocytosed hemozoin(malarial pigment) alters several functions of human monocytes and stimulates generation of several cytokines.Recently,we showed that phagocytosis of hemozoin by human monocytes increases expression and activity of matrix metalloproteinase-9,a proteolytic enzyme available in specific gelatinase granules,which contain several enzymes including lysozyme.Present work investigated active lysozyme release after phagocytosis of hemozoin and its dependence on production of tumor necrosis factor alpha. Methods:After phagocytosis of hemozoin,hemozoin-containing trophozoites or control meals(opsonized nonparasitized red blood cells and latex particles),monocyte supematants were monitored for 2 hours,in presence of blocking anti-human tumor necrosis factor alpha antibodies or recombinant human tumor necrosis factor alpha cytokine in selected experiments.Lysozyme release was evaluated by a specific spectrometric assay measuring lysozyme activity after coincubation of cell supematants with suspensions of Mycrococcus Lysodeikticus,while levels of soluble tumor necrosis factor alpha were analyzed by specific enzyme-linked immunodsorbent assay. Results:Levels of lysozyme activity and soluble tumor necrosis factor alpha protein were increased in hemozoin in-or trophozoites-laden monocytes supematants.Phagocytosis per se(control meals) also increased lysozyme release,but levels were significantly lower than those obtained after phagocytosis of hemozoin or trophozoites. Interestingly,all effects on lysozyme release observed after phagocytosis were abrogated by blocking anti-human tumor necrosis factor alpha antibodies,while they were mimicked by recombinant human tumor necrosis factor alpha cytokine.Conclusions:Present work shows that phagocytosis of hemozoin promotes monocyte degranulation and enhances active lysozyme release.The effect requires tumor necrosis factor alpha mediation. | Mauro Prato Giribaldi G Arese P | 2009 | Asian Pacific Journal of Tropical Medicine2009，2，3： | 3 |
| 3 | Stochastic Viability and Invariance显示文摘 | Aubin J P Da Prato G | 1990 | Annali Scuola Normale Di Pisa1990，17，： | 1 |
| 4 | Factors affecting the healing response of the intrabony defects following guided tissue regeneration and access flap surgery 显示文摘 | Tonetti MS Pini Prato G Cortellini P | 1996 | J Clin Periodon- tol1996，23，： | 1 |
| 5 | Periodontal regeneration of human intrabony defects with titanium reinforced membranes显示文摘 | Cortellini P Pini Prato G Tonetti MS | 1995 | Periodontol1995，66，9： | 1 |
| 6 | Phasic insulin release and metabolic regulation in type 2 diabetes 显示文摘 | Del Prato S Marchetti P Bonadonna RC | 2002 | Diabetes2002，51，1： | 1 |
| 7 | Phasic insulin releasa and metabolic regulation in type 2 diabetes显示文摘 | Marchetti P Bonadonna RC | 2002 | Diabetes2002，51，1： | 1 |
| 8 | Phasic insulin releasa and metabolic regulation in type 2 diabetes 显示文摘 | Del Prato S Marchetti P Bonadonna R C | 2002 | Diabetes Care2002，51，1： | 1 |
| 9 | Phasic insulin release and metabolic regulation in type 2 diabetes显示文摘 | DEL PRATO S MARCHETTI P BONADONNA RC | 2002 | Diabetes2002，51，1： | 1 |
| 10 | Phasic insulin release and metabolic regulation in type 2 diabetes 显示文摘 | Del Prato S Marchetti P Bonadonna RC | 2002 | Diabetes2002，51，1： | 1 |
| 11 | Phasic insulin release and metabolic regulation in type 2 diabetes显示文摘 | Del Prato S Marchetti P Bonadonna RC | 2002 | Diabetes2002，51，： | 1 |
| 12 | Acute lung injury from me- chanical ventilation of moderately high airway pressure显示文摘 | TSUNO K PRATO P KOLOBOW T | 1990 | J Appl Physiol1990，69，26： | 1 |
| 13 | Beta-and alpha-cell dysfunction in type 2 diabetes显示文摘 | Del Prato S Marchetti P | 2004 | Horm Metab Res2004，36，： | 1 |
| 14 | Norovirus gastroenteritis general outbreak associated with raw shellfish consumption in south Italy 显示文摘 | Prato R Lopalco P L Chironna M | 2004 | BMC Infect Dis2004，4，1： | 1 |
| 15 | The pancreatic beta cell in human type 2 diabetes显示文摘 | Marchetti P Del Prato S Lupi R | 2006 | Nutr Metab Cardiovasc Dis2006，16，1： | 1 |
| 16 | Monoclonal CD5 + and CD5- B-lym- phocyte expansions are frequent in the peripheral blood of the elderly 显示文摘 | Ghia P Prato G Scielzo C | 2004 | Blood2004，103，12： | 1 |
| 17 | Targeting insulin resistance and beta-cell dysfunction: the role of thiazolidinediones显示文摘 | Del Prato S Marchetti P | 2004 | Diabetes Technol Ther2004，6，5： | 1 |
| 18 | Phasic insulin release and metabolic regulation in type 2 diabetes 显示文摘 | Del Prato S Marchetti P Bonadonna AC | 2002 | Diabetes2002，51，： | 1 |
| 19 | Acute lung injury from mechan- ical ventilation of moderately high airway pressure 显示文摘 | Tsuno K Prato P kolobow T | 1990 | J Appl Physiol1990，69，26： | 1 |
| 20 | Phasic insulin release and metabolic regulation in type 2 diabetes显示文摘 | Del Prato S Marchetti P Bonadonna RC | 2002 | Di-abetes2002，51，： | 1 |
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