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| 1 | Biliary strictures complicating living donor liver transplantation:Problems,novel insights and solutions显示文摘Biliary stricture complicating living donor liver transplantation(LDLT) is a relatively common complication, occurring in most transplant centres across the world. Cases of biliary strictures are more common in LDLT than in deceased donor liver transplantation. Endoscopic management is the mainstay for biliary strictures complicating LDLT and includes endoscopic retrograde cholangiography, sphincterotomy and stent placement(with or without balloon dilatation). The efficacy and safety profiles as well as outcomes of endoscopic management of biliary strictures complicating LDLT is an area that needs to be viewed in isolation, owing to its unique set of problems and attending complications; as such, it merits a tailored approach, which is yet to be well established. The diagnostic criteria applied to these strictures are not uniform and are over-reliant on imaging studies showing an anastomotic narrowing. It has to be kept in mind that in the setting of LDLT, a subjective anastomotic narrowing is present in most cases due to a mismatch in ductal diameters. However, whether this narrowing results in a functionally significant narrowing is a question that needs further study. In addition, wide variation in the endotherapy protocols practised in most centres makes it difficult to interpret the results and hampers our understanding of this topic. The outcome definition for endotherapy is also heterogenous and needs to be standardised to allow for comparison of data in this regard and establish a clinical practice guideline. There have been multiple studies in this area in the last 2 years, with novel findings that have provided solutions to some of these issues. This review endeavours to incorporate these new findings into the wider understanding of endotherapy for biliary strictures complicating LDLT, with specific emphasis on diagnosis of strictures in the LDLT setting, endotherapy protocols and outcome definitions. An attempt is made to present the best management options currently available as well as directions for future research in the area. | Harshavardhan B Rao Arjun Prakash Surendran Sudhindran Rama P Venu | 2018 | World Journal of Gastroenterology2018，24，19： | 14 |
| 2 | Garden rue inhibits the arachidonic acid pathway, scavenges free radicals, and elevates FRAP: role in inflammation显示文摘AIM:In the present study,the anti-inflammatory and antioxidant activities of the methanol extract of Ruta graveolens leaves(RG-M) were evaluated using various in vivo and in vitro models.METHOD:For anti-inflammatory activity,RG-M was administered by the oral route(p.o.) in a carrageenan–induced paw edema model,and by the intraperitoneal route(i.p.) in an exudative inflammation model.In vitro inhibition of cyclooxygenase and lipoxygenase enzymes was evaluated.In vitro antioxidant activity was also examined.Endogenous antioxidant status was further evaluated by ferric reducing ability of plasma model.RESULTS:RG-M showed maximum inhibition of carrageenan-induced edema(100 mg·kg-1–33.36%; 200 mg·kg-1–45.32% and 400 mg·kg-1–56.28%).In the exudative inflammation model,a significant reduction in leukocyte migration(200 mg·kg-1–54.75% and 400 mg·kg-1–77.97%) and protein exudation(200 mg·kg-1–31.14% and 400 mg·kg-1–49.91%) were observed.RG-M also exhibited inhibition of COX–1(IC50 182.27 μg·mL-1) and COX–2(IC50 190.16 μg·mL-1) as well as 5–LOX(IC50 215.71 μg·mL-1).Antioxidant activity was significant with improved endogenous antioxidant status.CONCLUSION:The results demonstrated the anti-inflammatory and antioxidant activity of RG-M with potent inhibitory effects on the arachidonic acid pathways. | Manjir Sarma Kataki Bibhuti B Kakoti Biman Bhuyan Ananya Rajkumari Prakash Rajak | 2014 | Chinese Journal of Natural Medicines2014，12，3： | 3 |
| 3 | Antibacterial screening of silver nanoparticles synthesized by marine micro algae显示文摘Objective:To explore the biosynthesis of silver nanoparticles synthesized by marine microalgae. Methods:Marine microalgae was collected from Central Marine Fisheries Research Institute (CMFRI,tuticorin) and cultured in the lab.Silver nanoparticles synthesis were observed in normal and microwave irradiated microalgae and screened against human pathogens for the presence of antimicrobials.Results:The presence of silver nanoparticle was confirmed by UV-Visible spectroscopy at 420 nm by the presence of plasmon peak.Further confirmation was done by scanning electron microscope(SEM).Conclusions:These results not only provide a base for further research but are useful for drug development in the present and future. | D Devina Merin S Prakash B Valentine Bhimba | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，10： | 2 |
| 4 | Enhanced single copy integration events in corn via particle bombardment using low quantities of DNA显示文摘 | Lowe B A Shiva Prakash N Way M | 2009 | Transgenic Research2009，18，6： | 1 |
| 5 | Effective Beneficiation of Low Grade Iron Ore Through Jigging Operation显示文摘 | Das B Prakash S Das S K | 2007 | Journal of Minerals and Materials Characterization and Engineering2007，7，1： | 1 |
| 6 | New mineral occurrences and mineralization processes:Wuda coal-fire gas vents of Inner Mongolia显示文摘 | Stracher G B Prakash A Schroeder P | 2005 | American Mineralogist2005，90，1112： | 1 |
| 7 | Study and development of conducting polymer-based electrochromic display devices显示文摘 | Somani Prakash Mandale A B Radhakrishnan S | 2000 | Acta Materialia2000，48，11： | 1 |
| 8 | Induced systemic resistance(ISR) in plants: Mechanism of action 显示文摘 | Choudhary D K Prakash A Johri B N | 2007 | Indian Journal of Microbiology2007，47，8： | 1 |
| 9 | Antioxidant and free radical scavenging activities of phenols from onion (AUium cepa) 显示文摘 | PRAKASH D SINGH B N UPADHYAY G | 2007 | Food Chemistry2007，102，4： | 1 |
| 10 | Electroosmotic flow behaviour of metal contaminated expansive soil显示文摘 | Sivapullaiah P V Nagendra Prakash B S | 2007 | Journal of Hazardous Materials2007，143，3： | 1 |
| 11 | Surface acidity study of Mn ^+-montmorillonite clay catalysts by FT-IR spectroscopy: Correlation with esterification activity 显示文摘 | Reddy C R Nagendrappa G Prakash B S J | 2007 | Catal Commun2007，8，： | 1 |
| 12 | Surface Modifica- tion in Microsystems and Nanosystems 显示文摘 | Shaury Prakash Karacor M B Banerjee S | 2009 | Surface Science Re- ports2009，64，： | 1 |
| 13 | The influence of the segregation of Cu-rich phase on the microstructural and impedance characteristics of CaCu3Ti4012 ceramics 显示文摘 | Prakash B S Varma K B R | 2007 | Journal of Materials Science2007，42，17： | 1 |
| 14 | Effect of Enzymatic Hydrolysis on Antigenicity (Allergenicity)of Casein Fractions of Cow and Buffalo Milk显示文摘 | PRAKASH E S S PUSHPA B P JAYAPRAKASHA H M | 2004 | Journal of Food Science and Technology2004，41，4： | 1 |
| 15 | Review of the lubrica-tion,sealing, and pumping mechanisms in oil-and-grease-lubricatedradial lip seals显示文摘 | Baart P Lugt P M Prakash B | 2008 | Proceedings of the Institution of MechanicalEngineers Tribology *2008，233，13： | 1 |
| 16 | A systematic methodology to characterize the running-in and steady-istate wear process显示文摘 | SETHURAMIAH A KUMAR R PRAKASH B | 2002 | Wear2002，252，： | 1 |
| 17 | Formation of aluminum titanate-mullite composite from bauxite red mud 显示文摘 | Mahata T Prakash D Sharma B P | 2007 | Metallurgical and Materials Transactions B2007，31，3： | 1 |
| 18 | Seismic Analysis of Steel Braced Reinforced Concrete Frames显示文摘 | Viswanath K G Prakash K B Anant Desai | 2010 | In- ternational Journal of Civil and Structure Engineering2010，1，1： | 1 |
| 19 | An overview ofutilization of slag and sludge from steel industries 显示文摘 | Das B Prakash S Reddy P S R Misra V N | 2007 | Resources Conservation and Recycling2007，50，1： | 1 |
| 20 | Effect of the addition of B203 alad BaO- B203-SIO2 glasses on the microstructure and dielectric properties of giant dielectric constant material CaCu3Ti4Oi2 显示文摘 | PRAKASH S B VARMA R B K | 2007 | J Solid State Chem2007，180，： | 1 |
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