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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Single-wall carbon nanotubes at ceramic grain boundaries显示文摘 | Vasiliev A L Poyato R Padture N P | 2007 | Scripta Materialia2007，56，6： | 1 |
| 3 | Effect of the concentration of suspended solids on the enzymatic activities and biodiversity of a submerged membrane bioreactor for aerobic treatment of domestic wastewater显示文摘 | M Molina-Munoz J M Poyatos R Vilchez | 2007 | Appl MicrobiolBiotechnol2007，73，6： | 1 |
| 4 | Automatic generation of consensus ground truth for the comparison of edge detection techniques显示文摘 | Garcia N L F Poyato A C Carnicer R M | 2008 | Image and Vision Computing2008，26，4： | 1 |
| 5 | Variation in the radial patterns of sap flux density in pubescent oak(Quercus pubescens)and its implications for tree and stand transpiration measurements显示文摘 | Poyatos R ∨Cermák J Llorens P | 2007 | Tree Physiology2007，27，4： | 1 |
| 6 | Single-wall carbon nanotubes at ceramic grain boundaries 显示文摘 | Vasiliev A L Poyato R Padture N P | 2007 | Scripta Materialia2007，56，： | 1 |
| 7 | A new look at water transport regulation in plants显示文摘 | Martinez-Vilaha J Poyatos R Aguad6 D | 2014 | New Phytologist2014，204，1： | 1 |
| 8 | Variation in the radial patterns of sap flux density in pubescent oak ( Quercus pubescens) and its implications for tree and stand transpiration measurements显示文摘 | Poyatos R Cermdk J Llorens P | 2007 | Tree physiology2007，27，4： | 1 |
| 9 | Variation in the radial patterns of sap flux density in pubescent oak (Qurecus pubescens) and its implication for tree and stand transpiration measurements显示文摘 | POYATOS R ERMK J LLORENS P | 2007 | Tree Physiology2007，27，4： | 1 |
| 10 | Compositional and structural study of ferroeleetric multiplayer (Pb,La)TiO3/(Pb,Ca)TiO3 sol-gel thin films显示文摘 | Calzada M L | 2004 | Journal of the European Ceramic Society2004，，24： | 1 |
| 11 | Effects of substrate annealing and post-crystallization thermal treatments on the functional properties of preferentially oriented (Pb,Ca)TiO3 thin filrns显示文摘 | POYATO R CALZADA M L PARDO L | 2003 | J Appl Phys2003，93，： | 1 |
| 12 | Effects of exenatide lar in type 2 diabetes mellitus and obesity 显示文摘 | SIERRA POYATOS R RIOB0 SERVAN P VAZQUEZ MARTINEZ C | 2014 | Nutr Hosp2014，31，1： | 1 |
| 13 | Automatic Generation of Consensus Ground Truth for the Comparison of Edge Detection Techniques显示文摘 | Garcfa N L F Poyato A C Camicer R M | 2007 | Image and Vision Computing2007，7，6： | 1 |
| 14 | Stress-induced depolarization of (Pb,La)TiO3 ferroelectric thin films by nanoindentation显示文摘 | ALGUERO M BUSHBBY A J REECE M J POYATO R RICOTE J CALZADA M L PARDO L | 2001 | Applied Physics Letters2001，79，： | 1 |
| 15 | Low temperature preparation of piezoelectric thin films by ultraviolet-assisted rapid thermal processing显示文摘 | Pardo L Poyato R Gonzdlez A | 2002 | Materials Science in Semiconductor Processing2002，，5： | 1 |
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