| 1 | High-throughput screening of mouse gene knockouts identifies established and novel skeletal phenotypes显示文摘Screening gene function in vivo is a powerful approach to discover novel drug targets. We present high-throughput screening(HTS) data for 3 762 distinct global gene knockout(KO) mouse lines with viable adult homozygous mice generated using either gene-trap or homologous recombination technologies. Bone mass was determined from DEXA scans of male and female mice at 14 weeks of age and by microCT analyses of bones from male mice at 16 weeks of age. Wild-type(WT) cagemates/littermates were examined for each gene KO. Lethality was observed in an additional 850 KO lines. Since primary HTS are susceptible to false positive findings, additional cohorts of mice from KO lines with intriguing HTS bone data were examined. Aging,ovariectomy, histomorphometry and bone strength studies were performed and possible non-skeletal phenotypes were explored. Together, these screens identified multiple genes affecting bone mass: 23 previously reported genes(Calcr, Cebpb, Crtap, Dcstamp, Dkk1, Duoxa2, Enpp1, Fgf23, Kiss1/Kiss1 r, Kl(Klotho),Lrp5, Mstn, Neo1, Npr2, Ostm1, Postn, Sfrp4, Slc30a5, Slc39a13, Sost, Sumf1, Src, Wnt10b), five novel genes extensively characterized(Cldn18, Fam20 c, Lrrk1, Sgpl1, Wnt16), five novel genes with preliminary characterization(Agpat2, Rassf5, Slc10a7, Slc26a7, Slc30a10) and three novel undisclosed genes coding for potential osteoporosis drug targets. | Robert Brommage Jeff Liu Gwenn M Hansen Laura L Kirkpatrick David G Potter Arthur T Ss Brian Zambrowicz David R Powell Peter Vogel | 2014 | Bone Research2014，2，3： | 7 |
| 2 | 基于平面肖特基二极管的W波段检波器显示文摘肖特基二极管技术为常温下毫米波信号的检测提供了有效的解决方案。它具有极低的寄生电容和级联电阻,可用于该频段的倍频器、混频器和检波器当中。相比于Galey Cell和热辐射测定器(Bolometer),基于肖特基二极管的直接检波技术具有低噪声、高反应率和常温使用的特点。本文介绍了一种基于波导结构的零偏置肖特基二极管检波器,采用E面探针传输波导基模电磁波,通过阻抗匹配实现微带线到二极管的耦合。测试结果表明,在-30 d Bm输入功率下:电压反应率的峰值可达8 900 V/W;在75 GHz^105 GHz的频率范围内,电压反应率在1 000 V/W以上。 | 刘海瑞 POWELL Jeff VIEGAS Colin ALDERMAN Byron 俞俊生 | 2016 | 太赫兹科学与电子信息学报2016，14，5： | 3 |
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