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| 1 | Is liver biopsy still needed in children with chronic viral hepatitis?显示文摘Liver biopsy is a standard method used for obtaining liver tissue for histopathological evaluation. Since reliable serological and virological tests are currently available, liver biopsy is no longer needed for the etiological diagnosis of chronic hepatitis B and C. However, liver histology remains the gold standard as a prognostic tool, providing information about the liver disease progression(grading of necroinflammatory activity and staging of fibrosis) and serving clinicians in the management and therapeutic decisions. In general, histopathological evaluation is indicated before starting the antiviral treatment. Main limitations of the liver biopsy include its invasive and painful procedure, sampling errors and the inter- and intra-observer variability. In addition, indications for the liver biopsy in pediatric patients with chronic viral hepatitis were questioned recently, and efforts have been made toward the development of non-invasive methods as an alternative to the liver biopsy. The most commonly used methods are novel imaging studies(elastography) and combinations of biomarkers. However, to date, none of these tests was validated in children with chronic viral hepatitis. In this review, we present the current status of the liver biopsy in the management of chronic viral hepatitis B and C in pediatric population, including specific indications, complications, contraindications, problems, limitations, and alternative non-invasive methods. | Maria Pokorska-?piewak Barbara Kowalik-Miko?ajewska Ma?gorzata Aniszewska Magdalena Pluta Magdalena Marczyńska | 2015 | World Journal of Gastroenterology2015，21，42： | 5 |
| 2 | The role of degenerative pathways in the development of irreversible consequences after brain ischemia显示文摘Ischemic stroke and irreversible consequences:Ischemic stroke in humans is the second most common cause of death in the world(Mozaffarian et al.,2016).The outcomes after a stroke are often dependent on complications,including motor disorders,depression and dementia(Pluta et al.,2018a),which causes a high risk of re-hospitalization and/or palliative care.This is also the main reason for long-term disability in people after stroke,with up to half of those who survived the stroke will not regain their independence until the end of their lives(Mozaffarian et al.,2016).According to epidemiological forecasts,human ischemic stroke will soon become the dominant cause of death worldwide(Bejot et al.,2016)as well as dementia with the phenotype of Alzheimer’s disease(AD;Kim and Lee 2018).It is suggested that human ischemic stroke and experimental brain ischemia in animals are associated with the possible development of AD neuropathology(Pluta et al.,2018a). | Ryszard Pluta Marzena U?amek-Kozio? | 2019 | Neural Regeneration Research2019，14，6： | 2 |
| 3 | The application of polyvinyl alcohol in the technology of modern drug form显示文摘 | Pluta J Karolewicz B | 2001 | Pllim Med2001，31，12： | 1 |
| 4 | Cerebral vasospasm fol-lowing subarachnoid hemorrhage: time for a new world of thought显示文摘 | Pluta RM Jacob HS Jens Dreier | 2009 | Neurol Res2009，31，2： | 1 |
| 5 | Cerebral vasospasm after subarachnoid hemorrhage:the emerging revolution显示文摘 | Macdonald RL Pluta RM Zhang JH | | 0，，05： | 1 |
| 6 | High–dose density chemotherapy followed by simple trachelectomy: full-term pregnancy显示文摘 | H. ROBOVA M. PLUTA M. HREHORCAK P. SKAPA L. ROB | 2008 | International Journal of Gynecological Cancer2008，，： | 1 |
| 7 | Cerebral vasospasm after subarachnoid hemorrhage:the emerging revolution显示文摘 | Macdonald RL Pluta RM Zhang JH | 2007 | Nat Clin Pract Neurol2007，3，： | 1 |
| 8 | Cerebral vasospasm after subarachnoid hemorrhage:the emerging revolution显示文摘 | Macdonald RL Pluta RM Zhang JH | 2007 | Nat Clin Pract Neurol2007，3，5： | 1 |
| 9 | Delayed cerebral vasospasm and nitric oxide: review,new hypothesis,and proposed treatment 显示文摘 | Pluta RM | 2005 | Pharmacol Ther2005，105，1： | 1 |
| 10 | Reduced sensitivity of platelets from type 2 diabetic patients to acetylsalicylic acid (aspirin)-its rela-tion to metabolic control显示文摘 | Watala C Golanski J Pluta J | | 0，，： | 1 |
| 11 | Long-term survival of endometrioid endometrial cancer patients显示文摘 | Gottwald L Pluta P Piekarski J | 2010 | Arch Med Sci2010，6，6： | 1 |
| 12 | Dielec- tric Properties of Polylactides and their Nanocomposites with Montmorillonite 显示文摘 | JESZKA J K PIETRZAK L PLUTA M | 2010 | Journal of Non - Crystalline Solids2010，356，1117： | 1 |
| 13 | Is the ischemic blood-brain barrier insufficiency responsible for full-blown Alzheimer's disease显示文摘 | Pluta R | | 0，，06： | 1 |
| 14 | Neuroprotection by the stable nitroxide Tempol during reperfusion in a rat model of transient foeal ischemia显示文摘 | Rak R Chao DL Pluta RM | | 0，，4： | 1 |
| 15 | Metamorphosis of subarach-noid hemorrhage research:from delayed vasospasm to early brain injury 显示文摘 | Sehba FA Pluta RM Zhang JH | 2011 | Molecular Neurobiology2011，43，1： | 1 |
| 16 | The importance of early brain injury after subarachnoid hemorrhage 显示文摘 | Sehba FA Hou J Pluta RM | 2012 | Prog Neurobiol2012，97，1： | 1 |
| 17 | Phase structure and viscoelastic properties of compatibilized blends of PET and HDPE Recyclates显示文摘 | Pluta M Bartczak Z Pawlak A | 2001 | J Appl Polym Sci2001，82，： | 1 |
| 18 | Increased protein glycation in diabetes mellitus is associated with decreased aspirin-mediated protein acetylation and reduced sensitivity of blood platelets to aspirin显示文摘 | Watala C Pluta J Golanski J | 2005 | J Mol Med2005，83，2： | 1 |
| 19 | Outcome of treatment in adults with Philadelphia chromosome-positive and/or BCR- ABL-positive acute lymphoblastic leukemia-retrospective analysis of Polish Adult Leukemia Group (PALG) 显示文摘 | Wrzesiefi-Ku: A Robak T Pluta A | 2006 | Ann Hematol2006，85，6： | 1 |
| 20 | Outcome of treatment in adults with philadelphia chromosome - positive and/or BCR - ABL - positive acute lymphoblastic leukemia - retrospective analysis of polish adult leukemia group (PALG) 显示文摘 | Wrzesien- Kus A Robak T Pluta A | 2006 | Ann Hematol2006，85，6： | 1 |
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