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| 1 | Caveolin-1 gene silencing promotes the activation of PI3K/AKT dependent on Erα36 and the transformation of MCF10A^(CE)显示文摘ERα36,a variant of estrogen receptor-α,acts as a dominant-negative factor in both estrogen-dependent and estrogen-independent transactivation signaling pathways,and is a key factor in the promotion,progression and prognosis of breast cancers.Caveolin-1,a 22-to 24-kD integral membrane protein,may function as a tumor suppressor in inhibiting of many growth-promoting signaling pathways.It was shown that downregulation of Caveolin-1 strengthens the interaction of ERα and Caveolin-1.In conclusion,Caveolin-1 gene silencing activated the PI3K/AKT signaling pathway in an ERα36-dependent way.Our finding may provide a promising therapeutic target of breast cancer. | FENG Shuang1,WANG Yang1,WANG Xi1,WANG ZhaoYi3,CUI YuYing1,LIU Jing4,ZHAO ChunHui1,JIN Mei1,2 & ZOU Wei1,2 1 College of Life Science,Liaoning Normal University,Dalian 116029,China 2 Liaoning Key Laboratory of Biotechnology and Molecular Drug R&D,Dalian 116029,China 3 Cancer Center,Creighton University,2500 California Plaza,Omaha,NE 68178,USA 4 First Clinical Hospital of Dalian Medical University,Dalian 116011,China | 2010 | Science China(Life Sciences)2010，53，5： | 16 |
| 2 | Hybrid first and second order attention Unet for building segmentation in remote sensing images显示文摘Recently,building segmentation(BS)has drawn significant attention in remote sensing applications.Convolutional neural networks(CNNs)have become the mainstream analysis approach in this field owing to their powerful representative ability.However,owing to the variation in building appearance,designing an effective CNN architecture for BS still remains a challenging task.Most of CNN-based BS methods mainly focus on deep or wide network architectures,neglecting the correlation among intermediate features.To address this problem,in this paper we propose a hybrid first and second order attention network(HFSA)that explores both the global mean and the inner-product among different channels to adaptively rescale intermediate features.As a result,the HFSA can not only make full use of first order feature statistics,but also incorporate the second order feature statistics,which leads to more representative feature.We conduct a series of comprehensive experiments on three widely used aerial building segmentation data sets and one satellite building segmentation data set.The experimental results show that our newly developed model achieves better segmentation performance over state-of-the-art models in terms of both quantitative and qualitative results. | Nanjun HE Leyuan FANG Antonio PLAZA | 2020 | Science China(Information Sciences)2020，63，4： | 15 |
| 3 | Functions of NKG2D in CD8^(+) T cells: an opportunity for immunotherapy显示文摘Natural killer group 2 member D(NKG2D)is a type II transmembrane receptor.NKG2D is present on NK cells in both mice and humans,whereas it is constitutively expressed on CD8+T cells in humans but only expressed upon T-cell activation in mice.NKG2D is a promiscuous receptor that recognizes stress-induced surface ligands.In NK cells,NKG2D signaling is sufficient to unleash the killing response;in CD8+T cells,this requires concurrent activation of the T-cell receptor(TCR).In this case,the function of NKG2D is to authenticate the recognition of a stressed target and enhance TCR signaling.CD28 has been established as an archetype provider of costimulation during T-cell priming.It has become apparent,however,that signals from other costimulatory receptors,such as NKG2D,are required for optimal T-cell function outside the priming phase.This review will focus on the similarities and differences between NKG2D and CD28;less well-described characteristics of NKG2D,such as the potential role of NKG2D in CD8+T-cell memory formation,cancer immunity and autoimmunity;and the opportunities for targeting NKG2D in immunotherapy. | Kushal Prajapati Cynthia Perez Lourdes Beatriz Plaza Rojas Brianna Burke Jose A Guevara-Patino | 2018 | Cellular & Molecular Immunology2018，15，5： | 7 |
| 4 | Spatio-temporal fusion for remote sensing data:an overview and new benchmark显示文摘Spatio-temporal fusion(STF)aims at fusing(temporally dense)coarse resolution images and(temporally sparse)fine resolution images to generate image series with adequate temporal and spatial resolution.In the last decade,STF has drawn a lot of attention and many STF methods have been developed.However,to datethe STF domain still lacks benchmark datasets,which is a pressing issue that needs to be addressed in order to foster the development of this field.In this review,we provide(for the first time in the literature)a robust benchmark STF dataset that includes three important characteristics:(1)diversity of regions,(2)long timespan,and(3)challenging scenarios.We also provide a survey of highly representative STF techniques,along with a detailed quantitative and qualitative comparison of their performance with our newly presented benchmark dataset.The proposed dataset is public and available online. | Jun LI Yunfei LI Lin HE Jin CHEN Antonio PLAZA | 2020 | Science China(Information Sciences)2020，63，4： | 7 |
| 5 | A new sensor bias-driven spatio-temporal fusion model based on convolutional neural networks显示文摘Owing to the tradeoff between scanning swath and pixel size,currently no satellite Earth observation sensors are able to collect images with high spatial and temporal resolution simultaneously.This limits the application of satellite images in many fields,including the characterization of crop yields or the detailed investigation of human-nature interactions.Spatio-temporal fusion(STF)is a widely used approach to solve the aforementioned problem.Traditional STF methods reconstruct fine-resolution images under the assumption that changes are able to be transferred directly from one sensor to another.However,this assumption may not hold in real scenarios,owing to the different capacity of available sensors to characterize changes.In this paper,we model such differences as a bias,and introduce a new sensor bias-driven STF model(called BiaSTF)to mitigate the differences between the spectral and spatial distortions presented in traditional methods.In addition,we propose a new learning method based on convolutional neural networks(CNNs)to efficiently obtain this bias.An experimental evaluation on two public datasets suggests that our newly developed method achieves excellent performance when compared to other available approaches. | Yunfei LI Jun LI Lin HE Jin CHEN Antonio PLAZA | 2020 | Science China(Information Sciences)2020，63，4： | 7 |
| 6 | Adenoviral-mediated Hath1-EGFP gene transfer into guinea pig cochlea through intact round window membrane显示文摘Objective To study expression of adenoviral-mediated Hath1-EGFP gene in the guinea pig cochlea after transfer through intact round window membrane(RWM), and to assess its effects on hearing. Methods Twenty adult guinea pigs were used, of which: 12 were surgically inoculated with Ad-Hath1-EGFP in the bony groove of round window niche, and 8 with artificial perilymph. Auditory brainstem response(ABR) thresholds were determined in all animals before and 5 days after surgery. On post-surgery day 5 and day 14, animals were sacrificed and whole mounts of cochlea and frozen sections were examined. Results ABR tests showed no significant change of hearing after the surgery. Strong fluorescence staining in the cochleae was seen in Ad-Hath1-EGFP groups. The highest levels of gene expression were seen in the post-surgery day 5 group with little decrease on post-surgery day 14.The contralateral cochlea and those in the control groups were free of fluorescence staining. Conclusion The transgenic Hath1-EGFP can be effectively delivered into the inner ear through intact RWM, in an atraumatic manner. | CHEN Wei1☆, HU Yin-yan1☆, YANG Shi-ming1*, GUO Wei1, SUN Jian-he1, HAN Dong-yi1, ZHAI Suo-qiang1, YANG Wei-yan1, David Z.Z.He2 1. Neurologic Biological centre, Institute of Otolaryngology, Department of Otorhinolaryngology-Head & Neck Surgery, Chinese PLA General Hospital, Beijing 100853, China 2. Department of Biomedical Sciences, Creighton University, 2500 California Plaza, Omaha, NE 68175, USA | 2008 | Journal of Otology2008，3，1： | 7 |
| 7 | Effects of Composted and Thermally Dried Sewage Sludges on Soil and Soil Humic Acid Properties显示文摘The effect of annual additions of composted sewage sludge (CS) and thermally dried sewage sludge (TS) at 80 t ha-1 on soil chemical properties was investigated for three years in a field experiment under semiarid conditions. Humic acids (HAs) isolated by conventional procedures from CS, TS, and unamended (SO) and sludge amended soils were analysed for elemental (C, H, N, S and O) and acidic functional groups (carboxylic and phenolic) and by ultraviolet-visible, Fourier transform infrared and fluorescence spectroscopies. With respect to CS, TS had similar pH and total P and K contents, larger dry matter, total organic C, total N and C/N ratio and smaller ash content and electrical conductivity. Amendment with both CS and TS induced a number of modifications in soil properties, including an increase of pH, electrical conductivity, total organic C, total N, and available P. The CS-HA had greater O, total acidity, carboxyl, and phenolic OH group contents and smaller C and H contents than TS-HA. The CS-HA and TS-HA had larger N and S contents, smaller C, O and acidic functional group contents, and lower aromatic polycondensation and humification degrees than SO-HA. Amended soil-HAs showed C, H, N and S contents larger than SO-HA, suggesting that sludge HAs were partially incorporated into soil HAs. These effects were more evident with increasing number of sludge applications. | J. M. FERNNDEZ N. SENESI C. PLAZA G. BRUNETTI A. POLO | 2009 | Pedosphere2009，19，3： | 6 |
| 8 | Contractile effect of tachykinins on rabbit sma intestine显示文摘 | Marta Sofia VALERO Diego Santos FAGUNDES Laura GRASA Maria Pilar ARRUEBO Miguel Angel PLAZA Maria Divina MURILLO | 2011 | Acta Pharmacologica Sinica2011，32，4： | 5 |
| 9 | 遥感图像处理中的深度学习专题简介显示文摘深度学习是一种非常适用于大数据应用的新兴技术.在对地观测领域,由大量在轨卫星获取的海量遥感数据,使其成为数据驱动应用的典范.过去几年来,遥感图像处理相关的深度学习研究快速增长,包括高光谱遥感图像、合成孔径雷达(SAR)图像等处理、分类、参数反演及目标检测识别.除了遥感数据的高分辨率、高维度和大尺寸之外,该领域还存在一些特殊的挑战,如不同传感器及其不同工作模式的复杂性和特殊性,隐含在遥感数据中的独特物理属性,信息反演的物理原理等. | 徐丰 胡程 李军 Antonio PLAZA Mihai DATCU | 2020 | 中国科学:信息科学2020，50，4： | 4 |
| 10 | Biosorption of mercury by Macrocystis pyrifera and Undaria pinnatifida:Influence of zinc,cadmium and nickel显示文摘This study investigated the adsorption of Hg(Ⅱ) on Macrocystis pyrifera and Undaria pinnatifida in monometallic system in the presence of Zn(II),Cd(Ⅱ) and Ni(II).The two biosorbents reached the same maximum sorption capacity (q m = 0.8 mmol/g) for mercury.U.pinnatifida showed a greater affinity (given by the coefficient b of the Langmuir equation) for mercury compared to M.pyrifera (4.4 versus 2.7 L/mmol).Mercury uptake was significantly reduced (by more than 50%) in the presence of competitor heavy metals such as Zn(II),Cd(II) and Ni(Ⅱ).Samples analysis using an environmental scanning electron microscopy equipped with an energy dispersive X-ray microanalysis showed that mercury was heterogeneously adsorbed on the surface of both biomaterials,while the other heavy metals were homogeneous distributed.The analysis of biosorbents by Fourier transform infrared spectrometry indicated that Hg(Ⅱ) binding occurred on S=O (sulfonate) and N-H (amine) functional groups. | Josefina Plaza Marisa Viera Edgardo Donati Eric Guibal | 2011 | Journal of Environmental Sciences2011，23，11： | 3 |
| 11 | 2009年上半年全国煤炭经济运行分析显示文摘用详实的数据阐述了当前全国煤炭经济运行中原煤产量、铁路运量、煤炭销量等情况,分析了煤炭经济运行的主要特点,并提出相应的政策性建议,认为应密切关注市场变化,科学组织生产,加强总量调控,增强信息交流,加强行业自律,深化销售联合。 | China National Coal Association(China National Coal Association,Coal Plaza,Qingniangou Lu,Dongcheng District,Beijing 100713,China) | 2009 | 中国煤炭2009，，7： | 2 |
| 12 | 用有机修复剂实时修复受金属污染土壤:腐植酸在铜生物有效性中的作用显示文摘本研究的目的是测定从生物固体堆肥(BI)、风化褐煤(LE)、金属污染土壤和用BI或LE修复土壤中分离出的,与结构性质有关的Cu(Ⅱ)与腐植酸键结合的行为,来探究腐殖酸控制土壤Cu(Ⅱ)生物有效性作用。在pH=5和离子强度为0.1mol/L时用电位滴定和朗缪尔模型来获取所要测定的腐植酸络合Cu(Ⅱ)的能力和Cu(Ⅱ)-HA络合物的条件稳定常数。Cu(Ⅱ)络合能力随着酸性配合基的含量尤其是COOH基团、芳香族化合物和腐殖化程度的增加而增加,具体顺序如下:BI-HA | Pedro Soler-Rovira Engracia Madejón Paula Madejón César Plaza 刘洪军 刘新伟 | 2011 | 腐植酸2011，，6： | 2 |
| 13 | Study of photodegradation of the pefticide ethiofencarb in aqueous and non - aqueous media, by gas chromatograghy - mass spectrometry 显示文摘 | J Sanze - Asensio M Plaza - Medina M T Martinez - Soria M Perez -Clavijo | 1999 | Journal of Chromatograghy A1999，84，： | 2 |
| 14 | Special focus on deep learning in remote sensing image processing显示文摘As a newly emerging technology,deep learning is a very promising field in big data applications.Remote sensing applications often involve huge volume data obtained daily by numerous in-orbit satellites.This makes it a perfect area for data-driven applications.Over the past years,there has been an exponentially increasing interest in deep learning for remote sensing image processing,including not only optical imagery but also synthetic aperture radar(SAR)imagery.In addition to the rapidly growing size and spectral,spatial and temporal resolution of remote sensing data,there are other challenges that are unique in this area,e.g.the intrinsic complexity and particularity of each specific sensor and their multi-modality,the fundamental physical properties embedded in the data,the underlying principles for information retrieval,etc.To promote the research in this area,we have organized a special focus feature on deep learning in remote sensing image processing in the SCIENCE CHINA Information Sciences. | Feng XU Cheng HU Jun LI Antonio PLAZA Mihai DATCU | 2020 | Science China(Information Sciences)2020，63，4： | 2 |
| 15 | 在经历 transcatheter 的病人的 atrial 纤维性颤动的临床、预示的含意大动脉的阀门培植显示文摘 AIM: To study a cohort of consecutive patients under-going transcatheter aortic valve implantation (TAVI) and compare the outcomes of atrial fibrillation (AF) patients vs patients in sinus rhythm (SR). METHODS: All consecutive patients undergoing TAVI in our hospital were included. The AF group comprised patients in AF at the time of TAVI or with history of AF, and were compared with the SR group. Procedural, echocardiographic and follow-up variables were compared. Likewise, the CHA 2 DS 2-VASC stroke risk score and HAS-BLED bleeding risk score and antithrombotic treatment at discharge in AF patients were compared with that in SR patients. RESULTS: From a total of 34 patients undergoing TAVI, 17 (50%) were allocated to the AF group, of whom 15 (88%) were under chronic oral anticoagulation. Patients in the AF group were similar to those in the SR group except for a trend (P = 0.07) for a higher logistic EuroSCORE (28% vs 19%), and a higher prevalence of hypertension (82% vs 53%) and chronic renal failure (17% vs 0%). Risk of both stroke and bleeding was high in the AF group (mean CHA 2 DS 2-VASC 4.3, mean HAS-BLED 2.9). In the AF group, treatment at discharge included chronic oral anticoagulation in all except one case, and in association with an antiplatelet drug in 57% of patients. During a mean follow-up of 11 mo (maximum 32), there were only two strokes, none of them during the peri-procedural period: one in the AF group at 30 mo and one in the SR group at 3 mo. There were no statistical differences in procedural success, and clinical outcome (survival at 1 year 81% vs 74% in AF and SR groups, respectively, P = NS). CONCLUSION: Patients in AF undergoing TAVI show a trend to a higher surgical risk. However, in our cohort, patients in AF did not have a higher stroke rate compared to the SR group, and the prognosis was similar in both groups. | Pablo Salinas Raúl Moreno Luis Calvo Santiago Jiménez-Valero Guillermo Galeote Angel Sánchez-Recalde Teresa López-Fernández Sergio Garcia-Blas Diego Iglesias Luis Riera Isidro Moreno-Gómez Jose María Mesa Ignacio Plaza Rocio Ayala Rosa Gonzalez José-Luis López-Sendón | 2012 | World Journal of Cardiology2012，4，1： | 2 |
| 16 | Postoperative complications in gastrointestinal surgery: A “hidden” basic quality indicator显示文摘Postoperative complications represent a basic quality indicator for measuring outcomes at surgical units. At present, however, they are not systematically measured in all surgical procedures. A more accurate assessment of their impact could help to evaluate the real morbidity associated with different surgical interventions, establish measures for improvement, increase efficiency and identify benchmarking services. The Clavien-Dindo Classification is the most widely used system worldwide for assessing postoperative complications.However, the postoperative period is summarized by the most serious complication without taking into account others of lesser magnitude. Recently,two new scoring systems have emerged, the Comprehensive Complication Index and the Complication Severity Score, which include all postoperative complications and quantify them from 0(no complications) to 100(patient’s death), These allow the comparison of results. It is important to train surgical staff to report and classify complications and to record 90-d morbidity rates in all patients. Comparisons with other services must take into account patient comorbidities and the complexity of the particular surgical procedure. To avoid subjectivity and bias, external audits are necessary. In addition, ensuring transparency in the reporting of the results is an urgent obligation. | Roberto De la Plaza Llamas JoséM Ramia | 2019 | World Journal of Gastroenterology2019，25，23： | 2 |
| 17 | Safety and efficacy of combined long-acting beta-agonists and inhaled corticosteroids vs long-actlng beta-agonists monotherapy for stable COPD:a systematic review显示文摘 | Rodrigo GJ Castro-Rodriguez JA Plaza V | 2009 | Chest2009，136，4： | 1 |
| 18 | Case-based reasoning: foundational issues, methodological variations, and system approaches显示文摘 | AAMODT A PLAZA E | 1994 | AI Communications1994，7，1： | 1 |
| 19 | Effect of combined treatments of high-pressure, citric acid and sodium chloride on quality parameters of tomata puree显示文摘 | Plaza L Mun-tz M de Ancos B | 2003 | European and Food Research and Technology2003，216，6： | 1 |
| 20 | Case-based reasoning: Foundational issues, methodological variations, and system approaches 显示文摘 | Aamodt A Plaza E | 1994 | AI communications1994，7，1： | 1 |
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