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| 1 | SIRT3-mediated inhibition of FOS through histone H3 deacetylation prevents cardiac fibrosis and inflammation显示文摘Sirtuin 3(SIRT3)is a deacetylase that modulates proteins that control metabolism and protects against oxidative stress.Modulation of SIRT3 activity has been proposed as a promising therapeutic target for ameliorating metabolic diseases and associated cardiac disturbances.In this study,we investigated the role of SIRT3 in inflammation and fibrosis in the heart using male mice with constitutive and systemic deletion of SIRT3 and human cardiac AC16 cells.SIRT3 knockout mice showed cardiac fibrosis and inflammation that was characterized by augmented transcriptional activity of AP-1.Consistent with this,SIRT3 overexpression in human and neonatal rat cardiomyocytes partially prevented the inflammatory and profibrotic response induced by TNF-α.Notably,these effects were associated with a decrease in the mRNA and protein levels of FOS and the DNA-binding activity of AP-1.Finally,we demonstrated that SIRT3 inhibits FOS transcription through specific histone H3 lysine K27 deacetylation at its promoter.These findings highlight an important function of SIRT3 in mediating the often intricate profibrotic and proinflammatory responses of cardiac cells through the modulation of the FOS/AP-1 pathway.Since fibrosis and inflammation are crucial in the progression of cardiac hypertrophy,heart failure,and diabetic cardiomyopathy,our results point to SIRT3 as a potential target for treating these diseases. | Xavier Palomer MSilvia Román-Azcona Javier Pizarro-Delgado Ana Planavila Francesc Villarroya Brenda Valenzuela-Alcaraz Fátima Crispi Álvaro Sepúlveda-Martínez Irene Miguel-Escalada Jorge Ferrer JFrancisco Nistal Raquel García Mercy MDavidson Emma Barroso Manuel Vázquez-Carrera | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 7 |
| 2 | Atorvastatin improves peroxisome proliferator-activated receptor signaling in cardiac hypertrophy preventing nuclear factor-KB activation 显示文摘 | Planavila A Laguna J C Vazquez-Carrera M | 2005 | Biochim Biophys Acta2005，1687，13： | 1 |
| 3 | Palmimte-induced interleukin 6 production is mediated by protein kinase C and nuclearfactor kappaB activation and leads to glucose transporter 4 down-regulation in skeletal muscle cells显示文摘 | PLANAVILA A LAGUNA J C | 2005 | Endocrinology2005，146，： | 1 |
| 4 | Palmitate induces tumor necrosis factor-alpha expression in C2 C12 skeletal muscle cells by a mechanism involving protein kinase C and nuclear factor-kappaB activation显示文摘 | PLANAVILA A SANCHCZ R M | 2006 | Endocrinology2006，147，： | 1 |
| 5 | Peroxisome proliferator-activated receptor beta/delta activation inhibits hypertrophy in neonatal rat cardiomyocytes 显示文摘 | Planavila A Rodriguez-Calvo R Jove M | 2005 | Cardiovasc Res2005，65，4： | 1 |
| 6 | Reductions in plasma cholesterol levels after fenofibrate treatment are negatively correlated with resistin expression in human adipose tissue显示文摘 | Jove M Planavila A Cabrero A | 2003 | Metabolism2003，，3： | 1 |
| 7 | SIRT1Acts in Association with PPARαto Protect the Heart from Hypertrophy,Metabolic Dysregulation,and Inflammation显示文摘 | PLANAVILA A IGLESIAS R GIRALT M | 2011 | Cardiovascular Research2011，90，2： | 1 |
| 8 | Palmitate-induced interleukin 6 production is mediated by protein kinase C and nuclear-faetor kB activation and leads to glucose transporter 4 down-regulation in skeletal muscle cells显示文摘 | JOVE M PLANAVILA A LAGUNA J C | 2004 | Endoerin2004，146，7： | 1 |
| 9 | Peroxisome proliferator-activated receptor beta/delta activation inhibits hypertrophy in neonatal rat cardiomyocytes显示文摘 | Planavila A Rodriguez-Calvo R Jove M | | 0，，： | 1 |
| 10 | Palmitate-induced intedeukin 6 production is mediated by protein kinase C and nuclear-factor kappa B activation and leads to glucose transporter 4 down-regulation in skeletal muscle cells显示文摘 | Joye M Planavila A Laguna JC | 2005 | Endocrinology2005，146，7： | 1 |
| 11 | Impaired expression of NADH dehydrogenase subunit 1 and PPAR coactivator-1 in skeletal muscle of ZDF rats:restoration by troglitazone 显示文摘 | JOVE M SALLA J PLANAVILA A | 2004 | J Lipid Res2004，45，1： | 1 |
| 12 | Impaired expression of NADH dehydrogenase subunit 1 and PPAR coactivator-1 in skeletal muscle of ZDF rats:Restoration by troglitazone显示文摘 | Jove M Salla J Planavila A | 2004 | J Lipid Res2004，45，1： | 1 |
| 13 | palmitate-induced inter leukin6 production is mediated by protein kinase C and nuclearfactor-κB activation and leads tO glucose transporter 4 down regulation in skeletal muscle cells显示文摘 | Jové M Planavila A Laguna J C | 2005 | Endocrinology2005，146，7： | 1 |
| 14 | Nuclear factor-kappaB activation leads to down-regulation of fatty acid oxidation during cardiac hypertrophy 显示文摘 | PLANAVILA A LAGUNA J C VaZQUEZ-CARRERA M | 2005 | J Biol Chem2005，280，17： | 1 |
| 15 | Reductions in plasma cholesterol levels after fenofibrate treatment are negatively correlated with resistin expression in human adipose tissue显示文摘 | Jove M Planavila A Cabrero A | 2003 | Metabolism2003，，3： | 1 |
| 16 | Sirtl acts in as- sociation with PPARalpha to protect the heart from hyper- trophy, metabolic dysregulation, and inflammation 显示文摘 | Planavila A Iglesias R Giralt M | 2011 | Cardiovasc Res2011，90，2： | 1 |
| 17 | Impaired expression of NADH dehydrogenase subunit 1 and PPARgamma coactivator-1 in skeletal muscle of ZDF rats:restoration by troglitazone显示文摘 | Salla J Planavila A | 2004 | J Lipid Res2004，45，1： | 1 |
| 18 | Atorvastatin improves peroxisome proliferator-activated receptor signaling in cardiac hypertrophy by preventing nuclear factor-κB activation显示文摘 | Planavila A Laguna JC Vazquez-Carrera M | 2005 | Biochimica Biophysica Acta2005，1687，： | 1 |
| 19 | Atorvastatin improves peroxisome proliferator-activated receptor signaling in cardiac hypertrophy by preventing nuclear factor-KB activation显示文摘 | Planavila A Laguna JC Vazguez-Carrera M | 2005 | Biochimica Biophysica Acta2005，1687，： | 1 |
| 20 | Reductions in plasma cholesterol levels after fenofibrate treatment are negatively correlated with resistin expression in human adipose tissue显示文摘 | Jov M Planavila A Cabrero A | 2003 | Metabolism2003，52，3： | 1 |
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