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| 1 | 高血压患者脑小血管病变化对认知功能的影响显示文摘高血压是脑小血管病进展与认知功能障碍的主要危险因素之一。该研究旨在探讨高血压患者脑小血管病损伤变化与认知功能减退及轻度认知功能障碍的关系。该研究的数据从ISSYS队列(探讨高血压无症状性脑卒中:一个磁共振成像研究)中获得,其是一项纵向人群研究,纳入基线无痴呆及脑卒中,年龄50~70岁的高血压患者。 | Jiménez-Balado J Riba-Llena I Abril O Garde E Penalba A Ostos E Maisterra O Montaner J Noviembre M Mundet X Ventura O Pizarro J Delgado P 赵狄 练桂丽 | 2019 | 中华高血压杂志2019，27，2： | 15 |
| 2 | Hepatic glycogenosis: An underdiagnosed complication of diabetes mellitus?显示文摘Hepatic glycogenosis(HG) is characterized by excessive glycogen accumulation in hepatocytes and represents a hepatic complication of diabetes that particularly occurs in patients with longstanding poorly controlled type 1 diabetes(T1D). HG has been reported to be a very rare disease, although it is believed to be extremely underdiagnosed because it is not possible to distinguish it from non-alcoholic fatty liver disease(NAFLD) unless a liver biopsy is performed. In contrast to HG, NAFLD is characterized by liver fat accumulation and is the more likely diagnosis for patients with type 2 diabetes and metabolic syndrome. The pathogenesis of HG involves the concomitant presence of insulin and excess glucose, which increases glycogen storage in the liver. HG is characterized by a transient elevation in liver transaminases and hepatomegaly. Differentiating between these two conditions is of the utmost importance because HG is a benign disease that is potentially reversible by improving glycemic control, whereas NAFLD can progress to cirrhosis. Therefore, HG should be suspected when liver dysfunction occurs in patients with poorly controlled T1 D. The aim of this article is to review the epidemiology, clinical characteristics, pathogenesis and histology of HG. | María Teresa Julián Núria Alonso Isabel Ojanguren Eduarda Pizarro Enric Ballestar Manel Puig-Domingo | 2015 | World Journal of Diabetes2015，6，2： | 4 |
| 3 | Photocatalytic bactericidal effect of TiO2 on enterobacter cloacae: comparative study with other Cram ( - ) bacteria 显示文摘 | Ibanez J A Litter M I Pizarro R A | 2003 | J Photochem Photobil A: Chem2003，157，1： | 1 |
| 4 | Variations in reflectance of tropical soils: spectral-chemical composition relationships from AVIRIS data 显示文摘 | GALVAO L S PIZARRO M A EPIPHANIO J C | 2001 | Remote Sensing of Environment2001，75，： | 1 |
| 5 | Hydrolysis of fish oil by lipases immobilized inside porous supports显示文摘 | FERN(A)NDEZ-LORENTE G PIZARRO C L(O)PEZ-VELA D | | 0，，06： | 1 |
| 6 | Optimization by experimental design of polyacrylamide gel composition as support for enzyme immobilization by entrapment 显示文摘 | Pizarro C Femandez-Torroba M A Benito C Gonzalez-Saiz J M | 1997 | Blotechnology and Bioengineering1997，53，5： | 1 |
| 7 | Adam33 gene polymorphisms in chronic obstructive pulmonary disease显示文摘 | PABST S PIZARRO TOURON C GILLISSEN A | 2009 | Eur J Med Res2009，14，4： | 1 |
| 8 | Eddy characteristics in the eastern South Pacific显示文摘 | Chaigneau A Pizarro O | 2005 | Journal of Geophysical Research:Oceans2005，110，6： | 1 |
| 9 | Dopaminergic DA1 signaling couples growthassociated protein-43 and long-term potentiation in guinea pig hippocampus显示文摘 | CHIRWA S ADUONUM A PIZARRO J | 2005 | Brain Res Bull2005，64，5： | 1 |
| 10 | Performance of cold-preserved rat liver Microorgans as the biological component of a simplified prototype model of bioartificial liver显示文摘AIM To develop a simplified bioartificial liver(BAL) device prototype, suitable to use freshly and preserved liver Microorgans(LMOs) as biological component. METHODS The system consists of 140 capillary fibers through which goat blood is pumped. The evolution of hema-tocrit, plasma and extra-fiber fluid osmolality was evaluated without any biological component, to characterize the prototype. LMOs were cut and cold stored 48 h in BG35 and Via Span~? solutions. Fresh LMOs were used as controls. After preservation, LMOs were loaded into the BAL and an ammonia overload was added. To assess LMOs viability and functionality, samples were taken to determine lactate dehydrogenase(LDH) release and ammonia detoxification capacity. RESULTS The concentrations of ammonia and glucose, and the fluids osmolalities were matched after the first hour of perfusion, showing a proper exchange between blood and the biological compartment in the minibioreactor. After 120 min of perfusion, LMOs cold preserved in BG35 and Via Span~? were able to detoxify 52.9% ± 6.5% and 53.6% ± 6.0%, respectively, of the initial ammonia overload. No significant differences were found with Controls(49.3% ± 8.8%, P < 0.05). LDH release was 6.0% ± 2.3% for control LMOs, and 6.2% ± 1.7% and 14.3% ± 1.1% for BG35 and Via Span~? cold preserved LMOs, respectively(n = 6, P < 0.05). CONCLUSION This prototype relied on a simple design and excellent performance. It’s a practical tool to evaluate the detoxification ability of LMOs subjected to different preservation protocols. | María Dolores Pizarro María Gabriela Mediavilla Alejandra Beatriz Quintana ángel Luis Scandizzi Joaquín Valentín Rodriguez María Eugenia Mamprin | 2016 | World Journal of Hepatology2016，8，33： | 1 |
| 11 | Variations in reflectance of tropical soils : spectral - chemical composition relationships from AVIRIS data 显示文摘 | Galv o L S Pizarro M A | 2001 | Remote Sensing of Environment2001，75，： | 1 |
| 12 | Dopaminergic DAlsignaling couples growth-associated protein-43 and long-term potentiation in guinea pig hippocampus显示文摘 | Chirwa S Aduonum A Pizarro J et ai | 2005 | Brain Res Bull2005，64，5： | 1 |
| 13 | Optimization by experimental design of polyacrylamide gel composition as support for enzyme immobilization by entrapment 显示文摘 | Pizarro C Fernandezz Torroba M A | 1997 | Biotechnology and Bioengineering1997，53，5： | 1 |
| 14 | Maintaining data integri- ty in microarray data management显示文摘 | Grant GR Manduchi E Pizarro A | 2003 | Biotechnology and bi- oengineering2003，，7： | 1 |
| 15 | Variations in reflectance of tropical soils: Spectral-chemical composition relationships from AVIRIS data显示文摘 | Galvao L S Pizarro M A Epiphanio J C N | 2001 | Remote Sensing of Environment2001，75，2： | 1 |
| 16 | Optimisation of the derivatisation reaction and sub- sequent headspace solid-phase microextraction method for the direct determination ofchlorophenols in red wine显示文摘 | MART1NEZ-URUNUELA A GONZALEZ-SAIZ J M PIZARRO C | 2004 | Journal of Chromatography A2004，1048，2： | 1 |
| 17 | Simulation of multispecies biofilm development in three dimensions 显示文摘 | Noguera D R Pizarro G Stahl D A | 1999 | Water Sci Technol1999，39，7： | 1 |
| 18 | Postpartum thyroid dysfunction and postpartum depression:Are they two linked disorders?显示文摘 | Lucas A Pizarro E Granada ML | 2004 | Clin Endocrinol (Oxf)2004，55，： | 1 |
| 19 | Optimization by experimental design of polyacrylamide gel composilion as support for enzyme immobilization by entrapment 显示文摘 | Pizarro C Femandez-Torroba M A Benito C | 1997 | Biotechnology and Bioengineeling1997，53，5： | 1 |
| 20 | Effect of enzyme supplementation of a diet based onbarley and actoclave treatment on apparent digestibility,growth performance and gut morphology of broilers显示文摘 | Viveros A Brenes A Pizarro M | 1994 | Anim Feed Sci Technol1994，48，： | 1 |
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