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| 1 | 高血压患者脑小血管病变化对认知功能的影响显示文摘高血压是脑小血管病进展与认知功能障碍的主要危险因素之一。该研究旨在探讨高血压患者脑小血管病损伤变化与认知功能减退及轻度认知功能障碍的关系。该研究的数据从ISSYS队列(探讨高血压无症状性脑卒中:一个磁共振成像研究)中获得,其是一项纵向人群研究,纳入基线无痴呆及脑卒中,年龄50~70岁的高血压患者。 | Jiménez-Balado J Riba-Llena I Abril O Garde E Penalba A Ostos E Maisterra O Montaner J Noviembre M Mundet X Ventura O Pizarro J Delgado P 赵狄 练桂丽 | 2019 | 中华高血压杂志2019，27，2： | 15 |
| 2 | Noninvasive model including right ventricular speckle tracking for the evaluation of pulmonary hypertension显示文摘AIM To find parameters from transthorathic echocardiography(TTE) including speckle-tracking(ST) analysis of the right ventricle(RV) to identify precapillary pulmonary hypertension(PH).METHODS Forty-four patients with suspected PH undergoing right heart catheterization(RHC) were consecutively included(mean age 63.1 ± 14 years, 61% male gender). All patients underwent standardized TTE including ST analysis of the RV. Based on the subsequent TTE-derived measurements, the presence of PH was assessed: Left ventricular ejection fraction(LVEF) was calculated by Simpsons rule from 4Ch. Systolic pulmonary artery pressure(s PAP) was assessed with continuous wave Doppler of systolic tricuspid regurgitant velocity and regarded raised with values ≥ 30 mmH g as a surrogate parameter for RA pressure. A concomitantly elevated PCWP was considered a means to discriminate between the precapillary and postcapillary form of PH. PCWP was considered elevated when the E/e' ratio was > 12 as a surrogate for LV diastolic pressure. E/e' ratio was measured by gauging systolic and diastolic velocities of the lateral and septal mitral valve annulus using TDI mode. The results were then averaged with conventional measurement of mitral valve inflow. Furthermore, functional testing with six minutes walking distance(6MWD), ECG-RV stress signs, NT pro-BNP and other laboratory values were assessed.RESULTS PH was confirmed in 34 patients(precapillary PH, n = 15, postcapillary PH, n = 19). TTE showed significant differences in E/e' ratio(precapillary PH: 12.3 ± 4.4, postcapillary PH: 17.3 ± 10.3, no PH: 12.1 ± 4.5, P = 0.02), LV volumes(ESV: 25.0 ± 15.0 mL, 49.9 ± 29.5 m L, 32.2 ± 13.6 m L, P = 0.027; EDV: 73.6 ± 24.0 mL, 110.6 ± 31.8 mL, 87.8 ± 33.0 mL, P = 0.021) and systolic pulmonary arterial pressure(sP AP: 61.2 ± 22.3 mm Hg, 53.6 ± 20.1 mm Hg, 31.2 ± 24.6 mm Hg, P = 0.001). STRV analysis showed significant differences for apical RV longitudinal strain(RVAS: -7.5% ± 5.6%, -13.3% ± 4.3%, -14.3% ± 6.3%, P = 0.03). NT pro-BNP was higher in patients with postcapillary PH(4677.0 ± 7764.1 pg/m L, precapillary PH: 1980.3 ± 3432.1 pg/mL, no PH: 367.5 ± 420.4 pg/mL, P = 0.03). Patients with precapillary PH presented significantly more often with ECG RV-stress signs(P = 0.001). Receiver operating characteristics curve analyses displayed the most significant area under the curve(AUC) for RVAS(cut-off < -6.5%, AUC 0.91, P < 0.001), sPAP(cut-off > 33 mmH g, AUC 0.86, P < 0.001) and ECG RV stress signs(AUC 0.83, P < 0.001). The combination of these parameters had a sensitivity of 82.8% and a specificity of 17.2% to detect precapillary PH. CONCLUSION The combination of non-invasive measurements allows feasible assessment of PH and seems beneficial for the differentiation between the pre- and postcapillary form of this disease. | Yossra Mahran Robert Schueler Marcel Weber Carmen Pizarro Georg Nickenig Dirk Skowasch Christoph Hammerstingl | 2016 | World Journal of Cardiology2016，8，8： | 4 |
| 3 | Hepatic glycogenosis: An underdiagnosed complication of diabetes mellitus?显示文摘Hepatic glycogenosis(HG) is characterized by excessive glycogen accumulation in hepatocytes and represents a hepatic complication of diabetes that particularly occurs in patients with longstanding poorly controlled type 1 diabetes(T1D). HG has been reported to be a very rare disease, although it is believed to be extremely underdiagnosed because it is not possible to distinguish it from non-alcoholic fatty liver disease(NAFLD) unless a liver biopsy is performed. In contrast to HG, NAFLD is characterized by liver fat accumulation and is the more likely diagnosis for patients with type 2 diabetes and metabolic syndrome. The pathogenesis of HG involves the concomitant presence of insulin and excess glucose, which increases glycogen storage in the liver. HG is characterized by a transient elevation in liver transaminases and hepatomegaly. Differentiating between these two conditions is of the utmost importance because HG is a benign disease that is potentially reversible by improving glycemic control, whereas NAFLD can progress to cirrhosis. Therefore, HG should be suspected when liver dysfunction occurs in patients with poorly controlled T1 D. The aim of this article is to review the epidemiology, clinical characteristics, pathogenesis and histology of HG. | María Teresa Julián Núria Alonso Isabel Ojanguren Eduarda Pizarro Enric Ballestar Manel Puig-Domingo | 2015 | World Journal of Diabetes2015，6，2： | 4 |
| 4 | CYP3A4 variant alleles in white individuals with low C YP3A4 enzyme activity 显示文摘 | Garcia-Martin E Martinez C Pizarro RM | 2002 | Clin Pharmacol Ther2002，71，： | 1 |
| 5 | Lipase--catalyzed production of biodiesel fuel from vegetable oils contained in waste activated bleaching earth显示文摘 | LARA AV PIZARRO E PARK Y | 2003 | Process Biochem2003，，38： | 1 |
| 6 | Changes in the structure and function of the human thrombin receptor during receptor activation,internalization, and recycling 显示文摘 | Brass LF Pizarro S Ahuja M | 1994 | J Biol Chem1994，269，4： | 1 |
| 7 | Polyacrylamide gels as support for enzyme immobilization by entrapment, effect of polyelectrolyte carrier, pH and temperature on enzyme action and kinetics parameters 显示文摘 | Gonzalez-Saiz J M Pizarro C | 2001 | European Polymer Journal2001，37，： | 1 |
| 8 | Independent prognostic value of elevated C-reactive protein in unstable angina显示文摘 | BOISSONNET C P PIZARRO R | 1999 | Circulation1999，100，： | 1 |
| 9 | Toward largearea mosaicing for underwater scientific application显示文摘 | Pizarro O Singh H | 2003 | IEEE Journal of Oceanic Engineering2003，28，4： | 1 |
| 10 | Systems biology perspective of wine fermentations 显示文摘 | Pizarro F Vargas Fand AgosinA E | 2007 | Yeast2007，，24： | 1 |
| 11 | Modeling of yeast metabolism and process dynamics in batch fermentation显示文摘 | SAINZ J PIZARRO F PE′ REZ-CORREA J R | 2003 | Biotechnology and Bioengineering2003，7，81： | 1 |
| 12 | Vinegar classification based on feature extraction and selection from headspace solid-phase microextraction/gas chromatography volatile analyses: A feasibility study显示文摘 | C. Pizarro I. Esteban-Díez C. Sáenz-González J.M. González-Sáiz | 2007 | Analytica Chimica Acta2007，，1： | 1 |
| 13 | Evaluation of angiogenesis in 77 pituitary adenomas using endoglin as a marker 显示文摘 | PIZARRO C B OLIVEIRA M C PEREIRA-LIMA J F | 2009 | Neuropathology2009，29，1： | 1 |
| 14 | Photocatalytic bactericidal effect of TiO2 on enterobacter cloacae: comparative study with other Cram ( - ) bacteria 显示文摘 | Ibanez J A Litter M I Pizarro R A | 2003 | J Photochem Photobil A: Chem2003，157，1： | 1 |
| 15 | Multiple response optimisation based on desirability functions of a microwave-assisted extraction method for the simultaneous determination of chloroanisoles and chlorophenols in oak barrel sawdust 显示文摘 | PIZARRO C GONZALEZ-SAIZ J M PEREZ-DEL-NOTARIO N | 2006 | J Chromatogr A2006，1132，12： | 1 |
| 16 | Adaptive continuous-scalemorphology for matrix fields 显示文摘 | Burgeth B Pizarro L Breuss M | 2011 | International Journal ofComputer Vision2011，92，： | 1 |
| 17 | C-reactive protein and the stress tests for the risk stratification of patients recovering from unstable angina pectoris 显示文摘 | Bazzino O Ferreiros E R Pizarro R | 2001 | Am J Cardiol2001，87，1： | 1 |
| 18 | Arsenic speciation in environmental and biological samples extraction and stability studies显示文摘 | PIZARRO I GOMEZ M CAMARA C | 2003 | Analytica Chimica Acta2003，，： | 1 |
| 19 | Treatment of dairy manure effluent using freshwater algae: Algal and recovery of manure nutrients using pilot-scale algal turf scrubbers 显示文摘 | Walter Mulbry Shannon Kondrad Carolina Pizarro | 2008 | Bioresource Technology2008，，99： | 1 |
| 20 | Variations in reflectance of tropical soils: spectral-chemical composition relationships from AVIRIS data 显示文摘 | GALVAO L S PIZARRO M A EPIPHANIO J C | 2001 | Remote Sensing of Environment2001，75，： | 1 |
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